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EPIGENETIC INACTIVATION OF TUMOR SUPPRESSOR GENES- MARKER FOR MONITORING THE EFFECTIVENESS OF THERAPY 肿瘤抑制基因的表观遗传失活--监测疗效的标志物
Global Journal of Medical and Pharmaceutical Sciences Pub Date : 2024-03-05 DOI: 10.55640/gjmps-abcd118
D. Kadirova, N.SH. Avezov, A. Ibragimov, A. N. Maksudova
{"title":"EPIGENETIC INACTIVATION OF TUMOR SUPPRESSOR GENES- MARKER FOR MONITORING THE EFFECTIVENESS OF THERAPY","authors":"D. Kadirova, N.SH. Avezov, A. Ibragimov, A. N. Maksudova","doi":"10.55640/gjmps-abcd118","DOIUrl":"https://doi.org/10.55640/gjmps-abcd118","url":null,"abstract":"Epigenetic inactivation of tumor suppressor genes caused by hypermethylation of the promoter area is as characteristic of the tumor process as genetic disorders, serving as an alternative mechanism of the function loss by the tumor suppressor genes. An analysis of the promoter area of RARв2 gene-suppressors has been performed in the normal condition and in breast cancer by methyl-sensitive polymerase chain reaction. Methylation of CpG-dinucleotides in the RARв2 gene promoter area was demonstrated. Abnormal methylation of the RARв2 gene promoter area may be used as a marker for early diagnosis and monitoring of the treatment efficacy in patients with the breast cancer.","PeriodicalId":517592,"journal":{"name":"Global Journal of Medical and Pharmaceutical Sciences","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140285977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE INFLUENCE OF FERMENTED ALOE CORTEX RESIDUE AS FEED ADDITIVES ON PIG GROWTH PERFORMANCE 发酵芦荟皮渣作为饲料添加剂对猪生长性能的影响
Global Journal of Medical and Pharmaceutical Sciences Pub Date : 2024-03-02 DOI: 10.55640/gjmps-abcd117
Jong-Min Choi, Won-Sik Chung
{"title":"THE INFLUENCE OF FERMENTED ALOE CORTEX RESIDUE AS FEED ADDITIVES ON PIG GROWTH PERFORMANCE","authors":"Jong-Min Choi, Won-Sik Chung","doi":"10.55640/gjmps-abcd117","DOIUrl":"https://doi.org/10.55640/gjmps-abcd117","url":null,"abstract":"This study investigates the influence of fermented aloe cortex residue as feed additives on pig growth performance. Aloe cortex residue, a byproduct of aloe vera processing, was subjected to fermentation to enhance its nutritional value and digestibility. Pigs were provided with feed containing varying concentrations of fermented aloe cortex residue, and their growth parameters, including weight gain, feed intake, and feed conversion ratio, were monitored over a specified period. Results indicate that the inclusion of fermented aloe cortex residue in pig feed positively impacts growth performance, suggesting its potential as a valuable feed additive in swine nutrition.","PeriodicalId":517592,"journal":{"name":"Global Journal of Medical and Pharmaceutical Sciences","volume":"63 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXAMINING THE IMPACT OF MINDFULNESS PRACTICE ON SUSCEPTIBILITY TO EVALUATIVE CONDITIONING: AN EXPERIMENTAL STUDY 研究正念练习对评价性条件反射易感性的影响：一项实验研究
Global Journal of Medical and Pharmaceutical Sciences Pub Date : 2024-03-01 DOI: 10.55640/gjmps-abcd116
Liangjing Wang
{"title":"EXAMINING THE IMPACT OF MINDFULNESS PRACTICE ON SUSCEPTIBILITY TO EVALUATIVE CONDITIONING: AN EXPERIMENTAL STUDY","authors":"Liangjing Wang","doi":"10.55640/gjmps-abcd116","DOIUrl":"https://doi.org/10.55640/gjmps-abcd116","url":null,"abstract":"This experimental study investigates the influence of mindfulness practice on susceptibility to evaluative conditioning, a psychological phenomenon wherein attitudes toward a neutral stimulus are modified through its association with positive or negative stimuli. A sample of participants underwent a mindfulness intervention, while another group served as controls. Both groups completed tasks involving evaluative conditioning paradigms, including measures of attitude change toward neutral stimuli paired with positive and negative stimuli. Results indicate that individuals who engaged in mindfulness practice exhibited reduced susceptibility to evaluative conditioning compared to control participants. These findings contribute to understanding the potential role of mindfulness in cognitive processes related to attitude formation and modification.","PeriodicalId":517592,"journal":{"name":"Global Journal of Medical and Pharmaceutical Sciences","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATING SINUS PATHOLOGIES IN CLEFT LIP AND PALATE PATIENTS: A CBCT ANALYSIS 评估唇腭裂患者的鼻窦病变：CBCT 分析
Global Journal of Medical and Pharmaceutical Sciences Pub Date : 2024-02-03 DOI: 10.55640/gjmps-abcd115
Zeynep Adem
{"title":"EVALUATING SINUS PATHOLOGIES IN CLEFT LIP AND PALATE PATIENTS: A CBCT ANALYSIS","authors":"Zeynep Adem","doi":"10.55640/gjmps-abcd115","DOIUrl":"https://doi.org/10.55640/gjmps-abcd115","url":null,"abstract":"This study presents a comprehensive assessment of sinus pathologies in cleft lip and palate (CLP) patients utilizing cone-beam computed tomography (CBCT). Cleft lip and palate patients often exhibit abnormalities in the maxillary sinus region due to congenital malformations and surgical interventions. The objective of this analysis is to investigate the prevalence, types, and severity of sinus pathologies in CLP patients using CBCT imaging. A retrospective review of CBCT scans from CLP patients was conducted, and sinus abnormalities such as mucosal thickening, sinus opacification, and anatomical variations were identified and analyzed. The findings shed light on the spectrum of sinus pathologies in CLP patients and underscore the importance of comprehensive evaluation in treatment planning and management.","PeriodicalId":517592,"journal":{"name":"Global Journal of Medical and Pharmaceutical Sciences","volume":"35 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140462203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
REVOLUTIONIZING DRUG DELIVERY: CUBOSOMES NANOPARTICLES AT THE FOREFRONT 给药革命：立方体纳米粒子走在前沿
Global Journal of Medical and Pharmaceutical Sciences Pub Date : 2024-01-01 DOI: 10.55640/gjmps-abcd114
Akshay Kallingal
{"title":"REVOLUTIONIZING DRUG DELIVERY: CUBOSOMES NANOPARTICLES AT THE FOREFRONT","authors":"Akshay Kallingal","doi":"10.55640/gjmps-abcd114","DOIUrl":"https://doi.org/10.55640/gjmps-abcd114","url":null,"abstract":"Cubosomes nanoparticles represent an innovative approach in drug delivery systems, offering unique advantages over traditional delivery methods. This paper explores recent advancements in cubosomes nanoparticles technology and their potential applications in pharmaceutical formulations. We discuss the structural characteristics, fabrication methods, and key properties of cubosomes nanoparticles, highlighting their ability to encapsulate hydrophilic and hydrophobic drugs, enhance drug stability, and facilitate controlled release. Furthermore, we examine the promising applications of cubosomes nanoparticles in targeted drug delivery, vaccine delivery, and theranostics. The review concludes with insights into future directions and challenges in the development and translation of cubosomes nanoparticles-based drug delivery systems.","PeriodicalId":517592,"journal":{"name":"Global Journal of Medical and Pharmaceutical Sciences","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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