International journal of sciences, basic and applied research最新文献

Inflammatory Biomarkers and Serum Fatty Acids in High-Risk Populations: A Research Protocol. 高危人群的炎症生物标志物和血清脂肪酸：一项研究方案。

International journal of sciences, basic and applied research Pub Date : 2026-01-01 Epub Date: 2026-04-08

Jatheender Kumar, Emmanuel Adediran, Flora Ukoli

{"title":"Inflammatory Biomarkers and Serum Fatty Acids in High-Risk Populations: A Research Protocol.","authors":"Jatheender Kumar, Emmanuel Adediran, Flora Ukoli","doi":"","DOIUrl":"","url":null,"abstract":"Background: Advances in hypertension management have resulted in a growing number of survivors in the United States. Despite the success of treatments, patients face long-term challenges and changes in health, and with the likelihood of developing more age-related comorbid disorders, related to cardiovascular, renal, pulmonary conditions, and stroke due to uncontrolled blood pressure and a reduction in life expectancy. This study hypothesizes that the increased risk of morbidity and mortality may be due to increased fat intake, resulting in the acceleration of hypertension.Methods: To address these questions, this study leverages an existing TLIP P-50 project (5P50MD01347-04) at Meharry Medical College in Nashville, TN. Participants will be examined at baseline and prospectively followed at 6, 12, 24, and 36 months to address three specific aims.Results: 1) to examine differences at baseline and in prospective rate of change of metabolic fatty acid assays as a function of blood Pressure progression; 2) to examine differences at baseline and in prospective rate of change of bio- markers assays as a function of Blood Pressure progression; 3) Inflammatory Bio markers and metabolic acid assay in relation to reduction of comorbidities associated with blood pressure.Conclusions: This study will determine whether monitoring inflammatory biomarkers and serum fatty acid assays over time can detect the progression of hypertension, with independent effects or through the interaction of behavioral factors in high-risk populations, and whether this approach can reduce the risk of age-related morbidities. Such information is necessary to define the risk population and to selectively target inflammatory biomarkers and fatty acid assays with the most effective efficacy and potential to reduce the risk of age-related morbidities.","PeriodicalId":517440,"journal":{"name":"International journal of sciences, basic and applied research","volume":"79 1","pages":"154-162"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148311124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Alcohol Consumption Frequency and Tobacco Use on Blood Pressure (DBP, SBP, HR): A Cross-Sectional Study. 酒精消费频率和烟草使用对血压（DBP， SBP， HR）的影响：一项横断面研究

International journal of sciences, basic and applied research Pub Date : 2025-08-22 Epub Date: 2025-09-16

Jatheender Kumar, Flora Ukoli, Emmanuel Adediran, Lisa Watson, Unjanae Johnson, Lisa Sherden, Chike Nzerue, Dontal Johnson, Adrian Samuels

{"title":"Impact of Alcohol Consumption Frequency and Tobacco Use on Blood Pressure (DBP, SBP, HR): A Cross-Sectional Study.","authors":"Jatheender Kumar, Flora Ukoli, Emmanuel Adediran, Lisa Watson, Unjanae Johnson, Lisa Sherden, Chike Nzerue, Dontal Johnson, Adrian Samuels","doi":"","DOIUrl":"","url":null,"abstract":"Alcohol consumption has been associated with higher blood pressure (BP) and an increased risk of developing chronic hypertension; however, the possible exposure thresholds and effect-modifiers are uncertain. A positive response relationship exists between smoking and hypertension, too, and both combined can result in detrimental health effects. This pilot project conducted BP screenings at community events, food drive events, and church community services around Davidson County in Nashville, Tennessee, from May 2025 to July 31, 2025. From the data, the study explored the correlation of smoking and alcohol consumption and its effect on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Heart Rate (HR). One hundred sixty-seven participants completed BP screenings at four public housing communities of Metropolitan Development Housing Authority (MDHA), three religious settings, i.e., community church, and two health fairs. Then, the study utilized generalized linear models to assess the association between alcohol consumption and tobacco use on BP measures. There were no significant associations between combined patterns of alcohol consumption and smoking on SBP, DBP, or HR. However, tobacco use alone was associated with a ninefold increase in HR, compared to non-users. Future studies should consider smoking patterns (e.g., daily versus occasional smoking), types (e.g., vaping versus cigarette use), and a larger population cohort to validate these results.","PeriodicalId":517440,"journal":{"name":"International journal of sciences, basic and applied research","volume":"78 1","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Design and Methods in Community Team Lifestyle Immersion Program for Chronic Disease Prevention and Control. 慢性病预防与控制社区团队生活方式浸入式项目的研究设计与方法。

International journal of sciences, basic and applied research Pub Date : 2025-05-17 Epub Date: 2025-07-26

Flora Ukoli, Jatheender Kumar, Chike Nzerue, Emmanuel Adediran, Dontal Johnson, Adrian Samuel, Stephania Miller-Hughes

{"title":"Research Design and Methods in Community Team Lifestyle Immersion Program for Chronic Disease Prevention and Control.","authors":"Flora Ukoli, Jatheender Kumar, Chike Nzerue, Emmanuel Adediran, Dontal Johnson, Adrian Samuel, Stephania Miller-Hughes","doi":"","DOIUrl":"","url":null,"abstract":"Persisting disparities in the control of chronic diseases are linked to several barriers to health prevention, including cultural norms, insufficient attention to health education, lack of access to physical activity, large serving portions, and excess added sodium and sugar by the food industry and restaurants [1]. In line with lifestyle modifications proposed for several decades [2, 3, 4, 5], the goal of this study is to develop and evaluate the efficacy of a Lifestyle Immersion intervention for chronic disease control. The study will be conducted in two settings, the community and the health facility, thus addressing the individual, interpersonal, and organizational levels. This study introduces the team concept in health behavior modification. It will compare the effectiveness of interventions among participants in the study's intervention arm (Team Arm) and the control group (Individual Arm). Participants will undergo a 6 month intervention adapted from the Centers for Disease Control and Prevention and the American Heart Association's recommendations for blood pressure control and cardiovascular health. Participants will receive education to increase relevant knowledge and training to develop the necessary skills, in addition to strategies for successfully adhering to LS7 and the DASH [6]. The primary study outcomes are systolic and diastolic blood pressure changes measured at enrollment and follow-up at 6 and 12 months. The secondary outcome measures include LS7 and DASH adherence scores at 6 and 12 months, as well as other pre-specified outcomes such as A1c, which assesses nutritional status at 6 and 12 months. The evidence for the effectiveness of lifestyle modification and the primary outcome of the study is controlling blood pressure through lifestyle modifications and promoting optimal health, particularly concerning African American populations [3, 10].","PeriodicalId":517440,"journal":{"name":"International journal of sciences, basic and applied research","volume":"77 1","pages":"213-225"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extent of Use of Aloe vera Locally Extracted Products for Management of Ailments in Communities of Kitagata Sub-county in Sheema District, Western Uganda. 乌干达西部希马区基塔加塔县社区使用当地提取的芦荟产品治疗疾病的程度。

International journal of sciences, basic and applied research Pub Date : 2014-01-01

Kamukama Adams, Twineomujuni Eliot, Agaba Gerald

{"title":"Extent of Use of Aloe vera Locally Extracted Products for Management of Ailments in Communities of Kitagata Sub-county in Sheema District, Western Uganda.","authors":"Kamukama Adams, Twineomujuni Eliot, Agaba Gerald","doi":"","DOIUrl":"","url":null,"abstract":"Aloe vera is widely used locally in communities in Uganda as a medicinal plant. It is said to contain various nutrient substances and vitamins that have curative properties. It is said to heal a variety of diseases in various communities. However the extent of use of this potential medicinal plant in Uganda and the various ailments for which it is used and the treatment outcomes are not clearly established and documented. In this cross-sectional study, carried out in August 2012 in Kitagata sub-county in Sheema district in western Uganda, data was collected from 131 randomly selected adult respondents using an interviewer administered semi-structured questionnaire. Key informants interviews and focused group discussions were also carried out with purposively selected participants. Data were collected on social demographic characteristics, practices and beliefs about Aloe vera. The data were analyzed using Excel version 2007 and Epi_Info software. To get the proportion of the community that use Aloe vera, the number of respondents that use aloe vera was expressed as a percentage of the total number of respondents. It was found out that all the respondents (100%) know aloe vera plant, 96.1% think that it can cure and 84.7% have ever used it. 90.9% of the respondents believe that Aloe vera is effective in curing ailments. 82.9% of these strongly believe in Aloe vera's effectiveness. The diseases reported included malaria (31%), wounds (23%), abdominal pains (16%) and skin diseases (9%) among others. It was significantly noted that all the participants who had ever used Aloe vera still believe in it. 92.0% respondents reported that they can recommend aloe vera to a friend or relative. Only one participant strongly disagrees that Aloe vera has any curative properties and has never used it.","PeriodicalId":517440,"journal":{"name":"International journal of sciences, basic and applied research","volume":"15 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0