Journal of Pharmaceutical and Biological Sciences最新文献

{"title":"Bio-markers of immuno-oncology","authors":"Tulsi Dipakbhai Patel, Gunjan, V. G. Vanteddu","doi":"10.18231/j.jpbs.2023.017","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.017","url":null,"abstract":"Since its inception until the rapid advancements, the immuno-oncology (I-O) landscape has undergone significant modifications. Thousands of possible I-O medicines and therapy combinations are being tested in clinical trials as part of the current drug development pipeline. Suppose these assets are to be developed effectively and successfully. In that case, it is necessary to invest in and use the proper techniques and technology to speed up the transition from preclinical evaluation to clinical development. These tools, which include suitable preclinical models, pharmacodynamics-related biomarkers, prediction and monitoring capabilities, and developing clinical trial designs, enable quick and effective evaluation during the development process.The possibility of new findings and insights in each of these three areas to further address the clinical care needs of patients with cancer.These tools include. 1. Appropriate preclinical models, 2. Biomarkers of pharmacodynamics, predictive and monitoring utility, and. 3. Evolving clinical trial designs allow rapid and efficient evaluation during the development process.This article provides an overview of how novel discoveries and insights into each of these three areas have the potential further to address the clinical management needs of patients with cancer.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"375 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of biodegradable nano medical patches incorporating a sustained-release pharmacological agent using electro-spinning technique","authors":"Afroj Ayyaj Shaikh, S. J. Anbhule","doi":"10.18231/j.jpbs.2023.015","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.015","url":null,"abstract":"Nano-polymer (self-disappearing) medical patches loaded with a long-acting drug (each substance separately) were created by electro-spinning synthetic polymers PVA and PVP at a rate of 10%W for each polymer and adding various medicinal substances, such as diclofenac de ethylamine and gentamicin, in concentrations of 5%w each. The morphological structure of the produced samples was further studied using a scanning electron microscope (SEM) and X-ray diffraction (XRD) before they were turned into a medical adhesive and tested directly on a human hand. This approach has already proven to be effective in delivering the medicine to the affected area without the use of any intermediaries. It is relatively simple to use, safe for medical usage, and inexpensive due to the lack of expensive industrial apparatus required for production.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"305 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological activities of essential oils from some flowers, plants and aromatic seeds – A review","authors":"M. Murali Krishna Kumar, Vijayalakshmi Nandikatti, K. P. Nagasree","doi":"10.18231/j.jpbs.2023.013","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.013","url":null,"abstract":"Volatile oils or essential oils are the secondary plant metabolites producing from different plant parts like flowers, leaves, fruits, seeds, stem, roots and their barks. These are chemically classified as terpenoids, which are hydrocarbons with a hydroxyl or carbonyl group. These are having different organic exercises and utilized as cure in Gastrointestinal issues, cold, hack, skin illnesses and so forth. These oils revealed for their pharmacological impacts like enemy of oxidant, hostile to bacterial, mitigating exercises and as Carminative. Ayurveda's founding country is India. There are numerous plants in India that can produce essential oils, which are frequently used in our daily lives. In this review, we want to talk about the biological activities of essential oils that come from flowers (like rose, jasmine, chrysanthemum, marigold), plant leaves (like marjoram, coriander, and mentha), and aromatic seeds (like fennel, caraway, cumin, and coriander), all of which are consumed on a daily basis and contribute to the cleanliness of our environment and health.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139963695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview: flexible and versatile approach of quality by design & process analytical technology in industries","authors":"Razia Kutty, Machindra Nikam, Sakshi Chaudhari, Chetana Shinde, Priya Gadakh, Pooja Niphade, Amit Kakad","doi":"10.18231/j.jpbs.2023.014","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.014","url":null,"abstract":"Quality by Design (QbD) is crucial to the creation of contemporary in pharmaceuticals, microbiology, biotechnology, product management etc. In order to build proactive, scientific, and risk-based processes and products, QbD helps and supports both the industry and the FDA. Instead of waiting until the final quality check of the finished product, it is founded on the idea of establishing quality from the very beginning of the process. A successful plan that lowers batch failures and recalls is finally provided by an efficient QbD approach, which offers insights and crucial upstream information throughout the development process. The purpose of this review is to provide an overview of the implementation of Quality by Design (QbD), its tools, elements, and techniques, the relevancy with various guidelines, and the use in present-day pharmaceutical. The IQ Consortium provides information on the current situation of process analytical technology (PAT) as it relates to the creation of active pharmaceutical ingredients (API) in branded pharmaceutical firms. The article gives concrete examples of why and how the pharmaceutical industry uses PAT tools in API development by using an API process pipeline. PAT can reduce personnel risks involved with sampling dangerous compounds for in-process testing and increase R&D efficiency. Although not all chemical processes or stages are easily suited to applying the features of the PAT toolbox, PAT permits accurate and speedy (real or near time) evaluations of processes that might involve compounds that are highly dangerous, transitory, or heterogeneous when necessary. The major regulatory agencies and the biotech sector have worked hard to assist the application of the ideas of Quality by Design (QbD) and Process Analytical Technology (PAT) over the past ten years, with varying degrees of success. Despite the fact that just one biotech therapy has received approval under the QbD paradigm thus far, the tools and methods associated with these two ideas are deeply ingrained in the work procedures of the majority of international pharmaceutical firms. This overview is mainly focused on the QbD and PAT's development in the first place. Second, give an overview of QbD and PAT implementation and point out any places where more contributions are possible.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"695 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabric phase sorptive extraction: A sustainable approach in analysis of pharmaceutical product","authors":"P. Prajapati, Nutan Patel, Divyesh Kankva","doi":"10.18231/j.jpbs.2023.019","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.019","url":null,"abstract":"As the pharmaceutical industry continues to evolve, there is an increasing demand for sustainable and efficient analytical techniques in the analysis of pharmaceutical products. This manuscript explores the application of Fabric Phase Sorptive Extraction (FPSE) as a novel and sustainable approach for the extraction and analysis of pharmaceutical compounds. FPSE, a recent advancement in sample preparation, offers a greener alternative by utilizing a fabric-like sorbent material. The environmentally friendly nature of FPSE, with reduced solvent consumption and waste generation, aligns with the principles of green analytical chemistry. Case studies involving the analysis of various pharmaceutical products showcase the versatility and applicability of FPSE in different matrices.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"692 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mouth dissolving film as a potential dosage form for paediatric usage","authors":"Bhupendra G. Prajapati, Priyanka Patel, Dhirendra C. Patel","doi":"10.18231/j.jpbs.2023.021","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.021","url":null,"abstract":"Drug delivery systems using thin films are being researched by the pharmaceutical industry. They're a diverse platform that can provide immediate, local, or systemic actions. Furthermore, these systems can be used independently, which is ideal for patients with dysphagia, elderly, pediatric, or bed-ridden patients, as well as those who may have difficulty consuming water. These drug delivery systems can be given by oral, buccal, sublingual, ocular and trans-dermal routes. This study explores mouth thin films in all of their characteristics from the current perspective, providing insight into the world's growing market share as a result of expanding research fields and technological breakthroughs. Simultaneously, It provides a summary of the key factors involved in formulation development that have an impact on thin films, such as thin film design, morphological and physiological limitations, production process selection, characterization techniques, and polymer and drug physicochemical properties. It also gives an overview of the most recent thin-film products made by major pharmaceutical firms.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"12 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tides of healing: Unlocking the therapeutic potential of marine drugs","authors":"F. Tamboli","doi":"10.18231/j.jpbs.2023.012","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.012","url":null,"abstract":"","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"428 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139893878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aptamers based targeted drug delivery system: A newer trend in cancer treatment therapy","authors":"Paramita Dey, Anushmita Ghosh, Subhrajit Sarker","doi":"10.18231/j.jpbs.2023.016","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.016","url":null,"abstract":"The investigation of targeted drug delivery systems as a way to improve therapeutic efficacy while minimizing adverse effects is a result of the development of novel cancer treatment strategies. This subject explores the exciting field of aptamer-based targeted drug delivery systems for the treatment of cancer. Short single-stranded DNA or RNA molecules called aptamers have a remarkable capacity to bind to particular target molecules with high specificity and affinity. Aptamers have drawn attention as excellent possibilities for creating targeted drug delivery systems by taking use of their special characteristic. The applications, choice, and modification of aptamers to precisely identify cancer-associated biomarkers, such as receptors overexpressed on cancer cells, are covered in detail in this topic. Additionally, it emphasizes various techniques for aptamer-drug conjugation optimization which ensure effective carrier delivery and regulated drug release inside the tumor microenvironment. It is investigated if aptamer-based systems have the ability to overcome problems such drug resistance, heterogeneity, and insufficient drug penetration within solid tumors.In conclusion, this article illuminates how aptamer-based targeted drug delivery systems have transformed the world of cancer treatment. It advances knowledge of these systems and their potential to transform cancer treatment by providing insights into design principles, delivery systems, and therapeutic results.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"22 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel positioning of L. (Black seed) from farm to pharma indexed in pharmacopeia","authors":"Rania I.M. Almoselhy, Afreen Usmani, Rania I.M. Almoselhy","doi":"10.18231/j.jpbs.2023.020","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.020","url":null,"abstract":"The current study examines the regulatory status and inclusion of in pharmacopeias across diverse regions. The regulatory landscape varies globally, with some countries recognizing it as a traditional medicine in pharmacopeias, while others impose restrictions due to safety and efficacy concerns. The lack of standardized guidelines complicates its status, ranging from dietary supplement to traditional herbal medicine in different regions. A pivotal shift is observed in the Egyptian Herbal Monograph Volume 3, marking Black Seed's evolution from traditional medicinal use to a recognized pharmaceutical preparation in the pharmacopeia. This transition signifies a move towards evidence-based medicine, emphasizing rigorous scientific scrutiny and standardization. The integration of Black Seed underscores growing recognition of its efficacy and safety, transforming it into a pharmaceutical product and consolidating its position in mainstream healthcare. The inclusion not only enhances patient accessibility but also instills confidence among healthcare practitioners, solidifying Black Seed as a trusted therapeutic agent. The debate around N. sativa's inclusion continues, with traditional medicine systems endorsing its value, while modern pharmacopeias grapple with standardization and quality control. N. sativa emerges as a promising natural resource, necessitating comprehensive documentation for its prospective inclusion in evidence-based healthcare practices and official guidelines.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"693 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and pharmacological review of cynodon dactylon grass with its potential effects","authors":"Shruti Amritkar, Jagruti Chavan, Amit V. Kakad, M.R.N. Shaikh","doi":"10.18231/j.jpbs.2023.018","DOIUrl":"https://doi.org/10.18231/j.jpbs.2023.018","url":null,"abstract":"Perennial herb Cynodon dactylon (L) Pers, family: Poeaceae, widespread throughout India. In several Indian languages, it is referred to by different names, including Durva in Marathi, Durba in Bengali, Dhro in Gujarati, Garichgaddi in Telugu, Arukampillu in Tamil, and Shataparva in Sanskrit. In traditional medical systems and ethnomedical practices, Cynodon dactylon plays a significant role. It is used in the form of powder, paste, or juice to treat a wide range of ailments due to its extensive therapeutic properties. Flavanoids, alkaloids, glycosides, terpenoides, triterpenoids, steroids, saponins, tannins, resins, phytosterols, reducing sugars, carbohydrates, proteins, volatile oils, and fixed oils were all found in Cynodon dactylon, according to the phytochemical examination. According to earlier research, Cynodon dactylon has properties that are protective, antimicrobial, antiparasitic, insecticidal, gastrointestinal, antioxidant, immunological, antiallergic, antiinflammatory, antipyretic, analgesic, anticancer, dermatological, diuretic, and immune system-related was found. In given review we studied some pharmacological aspects of Perennial herb Cynodon dactylon as well its versitile potential effect. The wide range of future aspects we can consider as best alternative medicine over chemical drugs.","PeriodicalId":517289,"journal":{"name":"Journal of Pharmaceutical and Biological Sciences","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}