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A comprehensive checklist of computational resources and methodologies for noncoding RNAs in systems medicine 系统医学中的非编码 RNA 计算资源和方法综合清单

WIREs RNA Pub Date : 2024-01-01 DOI: 10.1002/wrna.1830

Ruijiang Li, Caiyun Zhao, Ruiqi Wang, Jing Wang, Yiguang Jin, Song He, Xiaochen Bo

{"title":"A comprehensive checklist of computational resources and methodologies for noncoding RNAs in systems medicine","authors":"Ruijiang Li, Caiyun Zhao, Ruiqi Wang, Jing Wang, Yiguang Jin, Song He, Xiaochen Bo","doi":"10.1002/wrna.1830","DOIUrl":"https://doi.org/10.1002/wrna.1830","url":null,"abstract":"Noncoding RNAs (ncRNAs), previously referred to as “dark matter” and now recognized as “bright star,” fulfill a variety of biological functions and are also emerging as potential biomarkers and therapies in oncology‐focused clinical trials. Systems medicine has become a holist paradigm to study the human body, which organically integrates data from basic research and clinical practice to improve our understanding and treatment of complex diseases. It is an interdisciplinary approach that brings systems biology and bioinformatics closer to clinical medicine. The development of high‐throughput techniques and the increasing adoption of computational methods across healthcare domains have accelerated and aided the tangible clinical applications of ncRNAs. Various resources and methodologies for ncRNAs enable a comprehensive analysis of heterogeneous and interlinked data, thereby providing new insights into systems medicine. In this review, we summarize the resources and models for ncRNA medical research, aiming to provide a technical manual for personalized and precision medicine at the system level.This article is categorized under:\u0000RNA Methods > RNA Analyses In Vitro and In Silico\u0000","PeriodicalId":516712,"journal":{"name":"WIREs RNA","volume":"38 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of alternative splicing and splicing factors in diabetes: Current status and future perspectives 替代剪接和剪接因子在糖尿病中的作用：现状与未来展望

WIREs RNA Pub Date : 2024-01-01 DOI: 10.1002/wrna.1831

Didhiti Singha, Meghna Mondal, Dhruba Ghosh, Debopriya Choudhury, Bandana Chakravarti, Rajesh Kumar Kar, Pushkar Malakar

{"title":"The role of alternative splicing and splicing factors in diabetes: Current status and future perspectives","authors":"Didhiti Singha, Meghna Mondal, Dhruba Ghosh, Debopriya Choudhury, Bandana Chakravarti, Rajesh Kumar Kar, Pushkar Malakar","doi":"10.1002/wrna.1831","DOIUrl":"https://doi.org/10.1002/wrna.1831","url":null,"abstract":"With glucose being at the center of energy consumption and production, maintaining homeostasis of this simple sugar is of pivotal importance. Loss of glucose homeostasis results in altered blood glucose levels, that are frequently observed in type 2 diabetes (T2D) and obesity. T2D and obesity share pathophysiological mechanisms and genetic backgrounds. These conditions collectively impact over 500 million individuals worldwide, necessitating a deeper mechanistic understanding for effective therapeutic strategies. Recent studies have highlighted the involvement of abnormal alternative splicing (AS) and changes in splicing factors (SFs) in the development and progression of diabetic conditions, presenting AS and SFs as promising targets for therapy. This review focuses on the deregulation of AS (INSR, TCF7L2, and mTOR) and SF (Sam68) deregulation in diabetic conditions. In addition, we discuss the importance of mTOR signaling in diabetic conditions and its regulation by AS and SFs. Furthermore, we discuss current strategies aimed at targeting AS and SFs. Finally, we discuss research challenges, and unresolved questions in the field, and offer recommendations to enhance our comprehension of the significance of AS and SFs in the context of diabetes and obesity.This article is categorized under:\u0000RNA Processing > Splicing Mechanisms\u0000RNA Processing > Splicing Regulation/Alternative Splicing\u0000RNA in Disease and Development > RNA in Disease\u0000","PeriodicalId":516712,"journal":{"name":"WIREs RNA","volume":"60 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0