临床骨科杂志最新文献

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Ready-to-use hemostatic moldable bioactive bone putty for bone trauma treatment 随时可用的止血可塑生物活性骨腻子骨创伤治疗

临床骨科杂志 Pub Date : 2025-11-24 DOI: 10.1016/j.advop.2025.11.002

Zhen Yang, Peng Liu, Ying Chen, Ziyang Liu, Mingjun Li, Wei Chen, Juan Wang, Yangyang Xu, Yanjie Bai, Huan Zhou, Lei Yang

{"title":"Ready-to-use hemostatic moldable bioactive bone putty for bone trauma treatment","authors":"Zhen Yang, Peng Liu, Ying Chen, Ziyang Liu, Mingjun Li, Wei Chen, Juan Wang, Yangyang Xu, Yanjie Bai, Huan Zhou, Lei Yang","doi":"10.1016/j.advop.2025.11.002","DOIUrl":"https://doi.org/10.1016/j.advop.2025.11.002","url":null,"abstract":"For a long time, the clinical management of traumatic bone injuries has been limited by the constraints of bone wax as a hemostatic material. To tackle these clinical challenges, this study has developed a ready-to-use hemostatic moldable bioactive bone putty (BP) that excels in rapid hemostasis and promotes bone regeneration. BP is a formulation made from polyethylene glycol and pre-gelatinized hydroxypropyl distarch phosphate as a molding agent, along with calcium sulfate bone cement and calcium phosphate bone cement as bioactive components. While the application method remains the same as that of bone wax, BP encourages swift thrombus formation, significantly reducing coagulation time and blood loss. Additionally, BP improves its mechanical strength through hydration reactions upon exposure to bodily fluids, providing essential support for bone tissues while completely degrading within 8 weeks of implantation. In vitro cell studies have underscored the excellent biocompatibility of BP, demonstrating its capacity to stimulate the proliferation of BMSCs, increase the expression of key osteogenic genes, and increase calcium nodule deposition. Histological analyses have further revealed the positive impact of BP on osteogenesis, whereas in vivo experiments have shown significant inhibition of inflammatory fiber formation. Overall, the BP has emerged as an innovative solution for accelerating hemostasis and facilitating regenerative repair in cases of bone injury.","PeriodicalId":516419,"journal":{"name":"临床骨科杂志","volume":"2 1","pages":"132-141"},"PeriodicalIF":0.0,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional EGCG-loaded and silver-doped bioactive glass-reinforced calcium sulfate cement for chronic osteomyelitis management 多功能egcg负载和掺银生物活性玻璃增强硫酸钙水泥用于慢性骨髓炎的治疗

临床骨科杂志 Pub Date : 2025-11-20 DOI: 10.1016/j.advop.2025.11.001

Yulin Zhang, Qiyuan Dai, Yilin Ding, Jun Ma, Haorui Peng, Xiaodong Cao

{"title":"Multifunctional EGCG-loaded and silver-doped bioactive glass-reinforced calcium sulfate cement for chronic osteomyelitis management","authors":"Yulin Zhang, Qiyuan Dai, Yilin Ding, Jun Ma, Haorui Peng, Xiaodong Cao","doi":"10.1016/j.advop.2025.11.001","DOIUrl":"https://doi.org/10.1016/j.advop.2025.11.001","url":null,"abstract":"• The corporation of silver-doped bioactive glass improved the mechanical properties and enhanced osteogenic differentiation of calcium sulfate cement. • The addition of EGCG further promoted the DPPH scavenging and reduction of biofilm biomass in vitro . • Codelivery of EGCG and Ag + suppressed bacterial adhesion, and disrupted extracellular polymeric substance (EPS) formation. In clinical practice, chronic osteomyel itis often leads to bone tissue necrosis, with biofilm formation being a key factor in treatment failure. Although traditional antibiotic-loaded polymethacrylate (PMMA) bone cement is effective for initial bacterial inhibition, it faces challenges such as non-degradability, and the risk of promoting antibiotic resistance. Therefore, in this study, an epigallocatechin gallate (EGCG)-loaded biodegradable calcium sulfate (CSC) and silver-doped bioactive glass cement (AgBGC) composite bone cement was developed (E-AgCSBC). The combination of CSC and AgBGC enhanced the mechanical properties, effectively prolonged the setting time, and improved the anti-washout property of the CSC cement. The antibacterial properties of the composite cement were validated through plate coating and in vitro anti-biofilm tests. In addition, E-AgCSBC composite cement exhibited good cytocompatibility and promoted the migration and osteogenic differentiation of BMSCs in vitro , indicating its potential for the treatment of chronic osteomyelitis.","PeriodicalId":516419,"journal":{"name":"临床骨科杂志","volume":"2 1","pages":"142-153"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of umbilical cord mesenchymal stem cells and bioactive hydrogels in promoting regeneration of degenerated intervertebral discs 脐带间充质干细胞和生物活性水凝胶在促进退变椎间盘再生中的作用

临床骨科杂志 Pub Date : 2025-05-15 DOI: 10.1016/j.advop.2025.03.001

Jiaxiang Zhou, Jianmin Wang, Zhuo Song, Zhongyuan He, Zhen Li, Jiale Shao, Yukun Du, Jianyi Li, Wei Zhang, Cairong Li, Qiuxiao Tan, Zhiyu Zhou, Jianfeng Li, Manman Gao, Yongming Xi

引用次数: 0