肝癌研究(英文版)最新文献

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Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer. 夜班引起的昼夜节律紊乱：与非酒精性脂肪肝/非酒精性脂肪性肝炎的发病和肝癌风险有关。

IF 1.8

肝癌研究(英文版) Pub Date : 2024-10-30 DOI: 10.20517/2394-5079.2024.88

Anjali Singh, Baby Anjum, Qulsoom Naz, Sana Raza, Rohit A Sinha, Mohammad Kaleem Ahmad, Abbas Ali Mehdi, Narsingh Verma

{"title":"Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer.","authors":"Anjali Singh, Baby Anjum, Qulsoom Naz, Sana Raza, Rohit A Sinha, Mohammad Kaleem Ahmad, Abbas Ali Mehdi, Narsingh Verma","doi":"10.20517/2394-5079.2024.88","DOIUrl":"10.20517/2394-5079.2024.88","url":null,"abstract":"The circadian system plays a crucial role in regulating metabolic homeostasis at both systemic and tissue levels by synchronizing the central and peripheral clocks with exogenous time cues, known as zeitgebers (such as the light/dark cycle). Our body's behavioral rhythms, including sleep-wake cycles and feeding-fasting patterns, align with these extrinsic time cues. The body cannot effectively rest and repair itself when circadian rhythms are frequently disrupted. In many shift workers, the internal rhythms fail to fully synchronize with the end and start times of their shifts. Additionally, exposure to artificial light at night (LAN), irregular eating patterns, and sleep deprivation contribute to circadian disruption and misalignment. Shift work and jet lag disrupt the normal circadian rhythm of liver activity, resulting in a condition known as \"circadian disruption\". This disturbance adversely affects the metabolism and homeostasis of the liver, contributing to excessive fat accumulation and abnormal liver function. Additionally, extended working hours, such as prolonged night shifts, may worsen the progression of non-alcoholic fatty liver disease (NAFLD) toward non-alcoholic steatohepatitis (NASH) and increase disease severity. Studies have demonstrated a positive correlation between night shift work (NSW) and elevated liver enzymes, indicative of hepatic metabolic dysfunction, potentially increasing the risk of hepatocellular carcinoma (HCC) related to NAFLD. This review consolidates research findings on circadian disruption caused by NSW, late chronotype, jet lag, and social jet lag, drawing insights from studies involving both humans and animal models that investigate the effects of these factors on circadian rhythms in liver metabolism.","PeriodicalId":516355,"journal":{"name":"肝癌研究(英文版)","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver injury and recovery following radiation therapy for hepatocellular carcinoma: insights from functional liver imaging. 肝细胞癌放射治疗后的肝损伤和恢复：来自肝脏功能影像学的见解。

IF 1.7

肝癌研究(英文版) Pub Date : 2024-01-01 Epub Date: 2024-09-08 DOI: 10.20517/2394-5079.2024.27

Peter Zaki, Kanokphorn Thonglert, Smith Apisarnthanarax, Clemens Grassberger, Stephen R Bowen, Joseph Tsai, Jonathan G Sham, Bing-Hao Chiang, Matthew J Nyflot

{"title":"Liver injury and recovery following radiation therapy for hepatocellular carcinoma: insights from functional liver imaging.","authors":"Peter Zaki, Kanokphorn Thonglert, Smith Apisarnthanarax, Clemens Grassberger, Stephen R Bowen, Joseph Tsai, Jonathan G Sham, Bing-Hao Chiang, Matthew J Nyflot","doi":"10.20517/2394-5079.2024.27","DOIUrl":"https://doi.org/10.20517/2394-5079.2024.27","url":null,"abstract":"Aim: A critical need for hepatocellular carcinoma (HCC) management is understanding how the liver recovers following radiotherapy (RT). We hypothesized that functional liver imaging with 99mTc-sulfur colloid (SC) SPECT/CT provides additional information on liver injury and recovery after RT compared to conventional imaging.Methods: The liver function of patients with HCC was assessed using 99mTc-SC SPECT/CT imaging before and after definitive RT. The anatomical liver volume (ALV) was segmented on CT imaging. Liver function was measured as the total liver function (TLF) encompassing 30% of maximum SC uptake. Changes in ALV and TLF were compared to clinical characteristics.Results: Of 31 patients with evaluable post-RT SC SPECT/CT scans (total of 32), 23 had pre-treatment Child-Pugh (CP)-A and 9 had CP-B/C scores. The median follow-up post-RT was 57 days. The median change in ALV was -1.7% with no significant difference between CP-A and CP-B/C patients (P = 0.26) or between short- (32-99 days) and long-term (271-1120 days) follow-up imaging groups (P = 0.28). The median change in TLF post-RT was -24% and was significantly different between short- and long-term groups (-39% vs. 2%, P = 0.001) and between CP-A and CP-B/C patients (-19% vs. -57%, P = 0.002). TLF significantly decreased following treatment at all radiation dose levels, with the decline correlating with the dose (P < 0.001).Conclusion: Functional imaging provides additional information regarding liver injury and recovery following RT that conventional imaging cannot reveal. Patients with CP-A liver status showed less decline following RT and most had liver function near or above pre-treatment levels.","PeriodicalId":516355,"journal":{"name":"肝癌研究(英文版)","volume":"10 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0