{"title":"Effects of stem cell exosomes and sanqi-derived exosome-like nanoparticles on oxidative stress in skin cells","authors":"Xiaoting Zhang, Xiaomei Wang","doi":"10.55920/2771-019x/1797","DOIUrl":"https://doi.org/10.55920/2771-019x/1797","url":null,"abstract":"As the primary barrier against external damage, human skin is highly susceptible to oxidative stress, leading to cellular dysfunction. This study is the first to investigate the reparative effects and synergistic mechanisms","PeriodicalId":515161,"journal":{"name":"Journal of Clinical and Medical Images, Case Reports","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jcmimagescasereports.org/article/JCM-V5-1797.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Musculoskeletal loading from road cycling and distance running on bone bending strength and BMD in athletes","authors":"Michael T.C","doi":"10.55920/2771-019x/1644","DOIUrl":"https://doi.org/10.55920/2771-019x/1644","url":null,"abstract":"The purpose of this study was to determine whether chronic sport training comprising of low or nonimpact musculoskeletal loading in road cycling (CYC) and distance running (RUN) were associated with tibial and ulnar bending strength and calcaneus and wrist BMD in male athletes. Method. Study subjects included 12 road cyclists (CYC), 12 distance runners (RUN) and 12 physically active nonathletic (CON). Tibial and ulnar bending strength (EI, Nm2) were assessed using a mechanical response tissue analyzer (MRTA), and BMD (g/cm2) of the wrist and calcaneus were assessed using a peripheral X-ray absorptiometry. Group means differences among the study groups were determined using ANCOVA. Results. Ulnar bending strength (EI, Nm2) of CYC were higher than CON (62.0 ± 20 vs 44.7 ± 9 Nm2, p< 0.05), but not RUN. Tibial bending strength (EI, Nm2) of CYC and RUN were not higher than CON. Calcaneus BMD of RUN was higher than CON (0.666 ± 0.07 vs 0.579 ± 0.06 g/m2, p<0.05), but not CYC. Wrist BMD of CYC was not higher than (p = 0.07) RUN and CON. Conclusion. Chronic engagement in CYC training induces osteogenic adaptation for increased ulnar bending strength and RUN training induces increased calcaneus BMD.","PeriodicalId":515161,"journal":{"name":"Journal of Clinical and Medical Images, Case Reports","volume":"123 S169","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Very Rare Case of Primary Mural Endocarditis of the Right Atrium due to Candida Albicans","authors":"Theodorakis N","doi":"10.55920/2771-019x/1608","DOIUrl":"https://doi.org/10.55920/2771-019x/1608","url":null,"abstract":"Right-sided infective endocarditis accounts for 5-10% of all infective endocarditis cases. Fungal endocarditis represents 1-3% of all of infective endocarditis cases, with Candida spp. being the most common microbiological cause. Primary mural endocarditis is defined by the absence of valvular vegetations together with the presence of vegetations on the endocardial free wall that are not associated with myocardial abscesses, cardiac structural abnormalities, devices, prosthetic material, thrombi or tumors. It constitutes a very rare entity and only 63 cases have been published the literature. C. albicans is the microbiological cause in only nine of these cases, none of which involves the right atrium. We report the case of a frail 84-year-old female patient with a pacemaker presenting with fever. In the transthoracic and three-dimensional transesophageal echocardiograms, a mobile mass was found attached on the free wall of the right atrial base. Blood cultures were positive for C. albicans and the modified Duke criteria were fulfilled for a definite diagnosis of infective endocarditis. After evaluation from a heart team the patient was managed with transvenous lead extraction and intravenous high-dose caspofungin, according to the 2023 Guidelines of the European Society of Cardiology for the management of endocarditis. Pacemaker lead cultures were negative leading to the diagnosis of primary mural endocarditis. The patient responded well to treatment with significant clinical and laboratory improvement. Long-term oral fluconazole was initiated after hospital discharge with a close follow-up plan. To our knowledge this is the first case of primary mural endocarditis of the right atrium due to C. albicans.","PeriodicalId":515161,"journal":{"name":"Journal of Clinical and Medical Images, Case Reports","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}