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Journal of Cardiovascular Medicine and Cardiology最新文献

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Bempedoic acid: A new player in lipid-lowering 双鱼藤酸降血脂的新角色
Journal of Cardiovascular Medicine and Cardiology Pub Date : 2024-05-07 DOI: 10.17352/2455-2976.000205
Riesen Walter F
{"title":"Bempedoic acid: A new player in lipid-lowering","authors":"Riesen Walter F","doi":"10.17352/2455-2976.000205","DOIUrl":"https://doi.org/10.17352/2455-2976.000205","url":null,"abstract":"Elevated LDL cholesterol remains one of the most important cardiovascular risk factors. For this reason, great scientific efforts have been made in recent decades to reduce elevated LDL cholesterol levels. After statins, ezetrol, and PCSK9 inhibitors, bempedoic acid is a new promising option for the treatment of LDL-cholesterol. Bempedoic acid is an inhibitor of adenosine triphosphate citrate lyase (ACL), an enzyme that converts citrate to acetyl-CoA in the cytosol. The active ingredient thus attacks the above HMG-CoA reductase, the target of statins, in the mevalonate/cholesterol biosynthesis pathway. Bempedoic acid can be considered a prodrug that is converted intracellularly to ETC-1002-CoA by ACSVL1 (very long-chain acyl-CoA synthetase 1) via coenzyme A (CoA) activation. ACSVL1 is primarily expressed in the liver and not in skeletal muscle. Therefore, in contrast to statins, it is not associated with muscle pain, which is one of the great advantages of this drug.","PeriodicalId":513411,"journal":{"name":"Journal of Cardiovascular Medicine and Cardiology","volume":"128 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atherosclerosis and wine 动脉粥样硬化与葡萄酒
Journal of Cardiovascular Medicine and Cardiology Pub Date : 2024-03-12 DOI: 10.17352/2455-2976.000204
Kocmur Bozidar
{"title":"Atherosclerosis and wine","authors":"Kocmur Bozidar","doi":"10.17352/2455-2976.000204","DOIUrl":"https://doi.org/10.17352/2455-2976.000204","url":null,"abstract":"One of the most important risk factors for the origin and development of atherosclerosis is certainly excessive intake of fat in everyday nutrition. This risk factor, and the way it affects the origin and development of atherosclerosis, is described in the article “Atherosclerosis and lymph/risk factors”. In this article, based on verified and proven facts, it is suggested that the primary causes and initiators of atherosclerotic changes in the arterial system of the circulatory system are chylomicrons, especially large ones, which occur under the influence of several risk factors.","PeriodicalId":513411,"journal":{"name":"Journal of Cardiovascular Medicine and Cardiology","volume":"60 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140249366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raising awareness of cardiovascular diseases: A silent killer in South Africa 提高对心血管疾病的认识：南非的沉默杀手
Journal of Cardiovascular Medicine and Cardiology Pub Date : 2024-02-17 DOI: 10.17352/2455-2976.000203
Fihla Mteto Qhayiya
{"title":"Raising awareness of cardiovascular diseases: A silent killer in South Africa","authors":"Fihla Mteto Qhayiya","doi":"10.17352/2455-2976.000203","DOIUrl":"https://doi.org/10.17352/2455-2976.000203","url":null,"abstract":"Cardiovascular Disease (CVD) is the leading cause of death in Non-Communicable Diseases (NCDs) in the Republic of South Africa (RSA), surpassing all cancers combined. It is estimated that the disease is responsible for 215 deaths daily, with a 17.3% death rate. Common risk factors for the disease include hypertension, diabetes, hypercholesteremia, overweight and obesity, smoking, and stress. Contrary to well-known diseases like HIV/AIDS and TB, CVD does not enjoy enough publicity and attention from the population. This indicates a lack of awareness and concern for the disease among the general people, resulting in the disease being a continued burden on the healthcare system of RSA. The objective of this study was to examine the aetiology and classifications of CVD, identify cardiovascular risk factors, and explore strategies for preventing and managing the condition.","PeriodicalId":513411,"journal":{"name":"Journal of Cardiovascular Medicine and Cardiology","volume":"287 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cinnamon: A potent nutraceutical agent for the protection of the cardiovascular system 肉桂保护心血管系统的强效营养保健剂
Journal of Cardiovascular Medicine and Cardiology Pub Date : 2024-01-11 DOI: 10.17352/2455-2976.000202
Mohammadabadi Taherah, Rehman Asif Ur, Jain Rajesh
{"title":"Cinnamon: A potent nutraceutical agent for the protection of the cardiovascular system","authors":"Mohammadabadi Taherah, Rehman Asif Ur, Jain Rajesh","doi":"10.17352/2455-2976.000202","DOIUrl":"https://doi.org/10.17352/2455-2976.000202","url":null,"abstract":"Diseases such as diabetes, atherosclerosis, and hypertension are risk factors for Cardiovascular Diseases (CVDs). About 17.3 million deaths worldwide were due to CVDs in 2013 and is anticipated to be 23.3 million by 2030. Common therapies for CVDs are associated with wide side effects. Thus, herbal medicines have been regarded more due to fewer side effects, availability, cultural beliefs, and being cheap. For thousands of years, herbal medicine has been used for bacterial infections, colds, coughs, and CVDs. Cinnamon bark contains phenolic compounds such as cinnamaldehyde and cinnamic acid with protective properties that can reduce the risk of cardiovascular diseases, cardiac ischemia and hypertrophy, and myocardial infarction. Furthermore, cinnamon has antioxidant and anti-inflammatory properties and exhibits beneficial effects on the complications of diabetes, obesity, hypercholesterolemia, and hypertension which cause CVDs. Although the protective effects of cinnamon on the heart have been reported in many studies, it needs more clinical studies to prove the pharmaceutical and therapeutic efficacy of cinnamon on risk factors of CVDs. This review explains the protective effects of bioactive compounds of cinnamon on the cardiovascular system.","PeriodicalId":513411,"journal":{"name":"Journal of Cardiovascular Medicine and Cardiology","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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