Sclerosis Pub Date : 2024-07-04 DOI: 10.3390/sclerosis2030011

Allison R. Groux, Elizabeth S. Walker, F. Shemirani, Jennifer E. Lee, Amanda K. Irish, Linda M Rubenstein, Linda G. Snetselaar, Warren G Darling, T. Wahls, Tyler J. Titcomb

{"title":"Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials","authors":"Allison R. Groux, Elizabeth S. Walker, F. Shemirani, Jennifer E. Lee, Amanda K. Irish, Linda M Rubenstein, Linda G. Snetselaar, Warren G Darling, T. Wahls, Tyler J. Titcomb","doi":"10.3390/sclerosis2030011","DOIUrl":"https://doi.org/10.3390/sclerosis2030011","url":null,"abstract":"Emerging evidence links dietary interventions to favorable multiple sclerosis (MS) outcomes; however, evidence for the efficacy of dietary interventions on functional disability remains sparse. Data from two 12-week, randomized, controlled pilot trials were pooled to investigate the efficacy of a modified Paleolithic diet (Paleo) on functional disability, as assessed by the MS Functional Composite (MSFC), among people diagnosed with MS. Pooled baseline-referenced MSFC scores were calculated from the nine-hole peg test (NHPT), timed 25-foot walk (T25FW), and Paced Auditory Serial Addition Test (PASAT) Z-scores. There was no significant difference in the mean change in MSFC scores between groups (p = 0.07). In the Paleo group, a significant increase was observed in the MSFC scores (p = 0.03), NHPT (p < 0.001), and PASAT (p = 0.04) Z-scores at 12 weeks, indicating reduced functional disability compared to baseline values. No significant changes were observed within the Control group. Study-specific differences in the MSFC changes between groups were observed. Functional disability was reduced compared to the baseline in the Paleo group, possibly depending on MS type. These results provide preliminary observations on the efficacy of a modified Paleolithic diet for reducing or maintaining functional disability in MS.","PeriodicalId":513065,"journal":{"name":"Sclerosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current and Emerging Treatment Options in Pediatric Onset Multiple Sclerosis 小儿多发性硬化症的现有和新兴治疗方案

Sclerosis Pub Date : 2024-04-01 DOI: 10.3390/sclerosis2020007

Artemis Mavridi, Maria-Eleni Bompou, Aine Redmond, Paraschos Archontakis-Barakakis, George D. Vavougios, D. Mitsikostas, T. Mavridis

{"title":"Current and Emerging Treatment Options in Pediatric Onset Multiple Sclerosis","authors":"Artemis Mavridi, Maria-Eleni Bompou, Aine Redmond, Paraschos Archontakis-Barakakis, George D. Vavougios, D. Mitsikostas, T. Mavridis","doi":"10.3390/sclerosis2020007","DOIUrl":"https://doi.org/10.3390/sclerosis2020007","url":null,"abstract":"Pediatric onset multiple sclerosis (POMS), characterized by the onset of multiple sclerosis before the age of 18, is gaining increased recognition. Approximately 5 percent of MS cases manifest before the age of 18, with less than 1 percent occurring before the age of 10. Despite its rarity, pediatric MS exhibits distinct characteristics, with an association between younger age at onset and a comparatively slower disease progression. Despite this slower progression, individuals with POMS historically reach disability milestones at earlier ages than those with adult-onset multiple sclerosis. While various immunomodulatory agents demonstrate significant benefits in MS treatment, such as reduced relapse rates and slower accumulation of brain lesions on magnetic resonance imaging (MRI), the majority of disease-modifying therapies (DMTs) commonly used in adult MS lack evaluation through pediatric clinical trials. Current evidence is predominantly derived from observational studies. This comprehensive review aims to consolidate existing knowledge on the mechanisms of action, efficacy, safety profiles, and recommended dosages of available DMTs specifically in the context of pediatric MS. Furthermore, this review outlines recent advancements and explores potential medications still in developmental stages, providing a thorough overview of the current landscape and future prospects for treating POMS.","PeriodicalId":513065,"journal":{"name":"Sclerosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140775361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Cognitive Impairment in Multiple Sclerosis Patients 多发性硬化症患者认知障碍的风险因素

Sclerosis Pub Date : 2024-03-22 DOI: 10.3390/sclerosis2020006

T. Schreiner, Iustina Mihoc, Ecaterina Grigore, O. Schreiner

{"title":"Risk Factors for Cognitive Impairment in Multiple Sclerosis Patients","authors":"T. Schreiner, Iustina Mihoc, Ecaterina Grigore, O. Schreiner","doi":"10.3390/sclerosis2020006","DOIUrl":"https://doi.org/10.3390/sclerosis2020006","url":null,"abstract":"Cognitive impairment is one of the most significant burdens among the many neurological complaints in multiple sclerosis patients. Cognitive deficits negatively impact these patients’ quality of life, leading to partial or total loss of several mental functions, such as learning, memory, perception, or problem-solving. While the precise mechanisms involved in the onset and evolution of cognitive decline remain unknown, several risk factors have been associated with intellectual disability. With increasing data on this topic in recent years, the main aim of this review is to summarize the most relevant risk factors correlated with cognitive impairment in multiple sclerosis patients. Firstly, the authors demonstrate the importance of mental disability based on epidemiological data from multiple sclerosis patient cohorts. Subsequently, the intensely debated major risk factors for cognitive decline are discussed, with brief insights into the pathophysiology and possible underlying mechanisms. Finally, the authors describe the impact of medication on cognitive impairment in multiple sclerosis patients, highlighting the main research directions for future studies.","PeriodicalId":513065,"journal":{"name":"Sclerosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140219957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contextual Factors Matter: The Role of Social Support in Work-Related Difficulties and Employment Status in Persons with Multiple Sclerosis 环境因素很重要：社会支持在多发性硬化症患者工作相关困难和就业状况中的作用

Sclerosis Pub Date : 2024-03-05 DOI: 10.3390/sclerosis2010005

M. Román, Federico M. González, Lara Bardoneschi, Matias Herrera Fernández, M. Eizaguirre, Fernando Cáceres, Ralph H. B. Benedict, Victor M. Rivera, S. Vanotti

{"title":"Contextual Factors Matter: The Role of Social Support in Work-Related Difficulties and Employment Status in Persons with Multiple Sclerosis","authors":"M. Román, Federico M. González, Lara Bardoneschi, Matias Herrera Fernández, M. Eizaguirre, Fernando Cáceres, Ralph H. B. Benedict, Victor M. Rivera, S. Vanotti","doi":"10.3390/sclerosis2010005","DOIUrl":"https://doi.org/10.3390/sclerosis2010005","url":null,"abstract":"Background: People with Multiple Sclerosis (PwMS) have reported a higher unemployment rate compared to the general population. The complexity of environmental-contextual factors, such as structural and functional social support, may influence employment status (ES). Objectives: to study the relationship between perceived social support and ES, assess the effects of potential mediators, and analyze how these predictors influence components of ES, including absenteeism, work harassment, negative work events, and the use of accommodations. Material and Method: 90 PwMS were recruited. A single-visit assessment included: the Medical Outcomes Study Social Support Survey (MOS-SSS), the Buffalo Vocational Monitoring Survey, the Symbol Digit Modalities Test (SDMT), patient-reported outcomes measuring depression (Beck Depression Inventory-II (BDI-II) and fatigue (Fatigue Severity Scale), and the EDSS. Results: Sixty-three (70%) of PwMS were employed. Mediation analysis revealed the involvement of BDI-II and SDMT in the relationship between social support and ES. The functional social support of friends had a significant effect on absenteeism and NWEs. Total functional support was related to harassment, while family support had a significant effect on accommodations. Conclusion: These results show that structural and functional social support, in relation to the clinical variables of the disease, increase the probability of employment and a better quality of work.","PeriodicalId":513065,"journal":{"name":"Sclerosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Smartphone Applications in the Assessment and Management of Fatigue in Patients with Multiple Sclerosis: A Scoping Review 智能手机应用在多发性硬化症患者疲劳评估和管理中的作用：范围综述

Sclerosis Pub Date : 2024-02-11 DOI: 10.3390/sclerosis2010004

Annibale Antonioni, A. Baroni, Giada Milani, Irene Cordioli, S. Straudi

{"title":"Role of Smartphone Applications in the Assessment and Management of Fatigue in Patients with Multiple Sclerosis: A Scoping Review","authors":"Annibale Antonioni, A. Baroni, Giada Milani, Irene Cordioli, S. Straudi","doi":"10.3390/sclerosis2010004","DOIUrl":"https://doi.org/10.3390/sclerosis2010004","url":null,"abstract":"Fatigue is a common symptom in Multiple Sclerosis (MS), and its assessment depends entirely on patient reports. Importantly, managing MS symptoms is increasingly supported by Digital Health Technology (DHT), which includes Mobile Health Technology (mHT). Considering the growing interest, we aimed to synthesise evidence about smartphone applications for the assessment and management of fatigue in MS, as well as to investigate their usability, feasibility, and reliability. We performed a literature search in PubMed, Science Direct, and Embase using a scoping review approach. We included 16 articles and, although many lacked crucial methodological details, DHT was evaluated in all MS clinical subtypes and with disease durations up to more than 20 years. Despite the marked heterogeneity in terms of the employed methods, all documented a high degree of usability, assessed both as feedback from participants and completed tasks. Moreover, the feasibility assessment also showed good results, as apps were able to discriminate between patients with and without fatigue. Importantly, most also showed excellent results in terms of reliability, and some patients reported a reduction in fatigue thanks to mHT. Despite limitations, mHT has been positively evaluated by patients, suggesting a promising role of DHT in the self-management of MS.","PeriodicalId":513065,"journal":{"name":"Sclerosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139785954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Smartphone Applications in the Assessment and Management of Fatigue in Patients with Multiple Sclerosis: A Scoping Review 智能手机应用在多发性硬化症患者疲劳评估和管理中的作用：范围综述

Sclerosis Pub Date : 2024-02-11 DOI: 10.3390/sclerosis2010004

Annibale Antonioni, A. Baroni, Giada Milani, Irene Cordioli, S. Straudi

{"title":"Role of Smartphone Applications in the Assessment and Management of Fatigue in Patients with Multiple Sclerosis: A Scoping Review","authors":"Annibale Antonioni, A. Baroni, Giada Milani, Irene Cordioli, S. Straudi","doi":"10.3390/sclerosis2010004","DOIUrl":"https://doi.org/10.3390/sclerosis2010004","url":null,"abstract":"Fatigue is a common symptom in Multiple Sclerosis (MS), and its assessment depends entirely on patient reports. Importantly, managing MS symptoms is increasingly supported by Digital Health Technology (DHT), which includes Mobile Health Technology (mHT). Considering the growing interest, we aimed to synthesise evidence about smartphone applications for the assessment and management of fatigue in MS, as well as to investigate their usability, feasibility, and reliability. We performed a literature search in PubMed, Science Direct, and Embase using a scoping review approach. We included 16 articles and, although many lacked crucial methodological details, DHT was evaluated in all MS clinical subtypes and with disease durations up to more than 20 years. Despite the marked heterogeneity in terms of the employed methods, all documented a high degree of usability, assessed both as feedback from participants and completed tasks. Moreover, the feasibility assessment also showed good results, as apps were able to discriminate between patients with and without fatigue. Importantly, most also showed excellent results in terms of reliability, and some patients reported a reduction in fatigue thanks to mHT. Despite limitations, mHT has been positively evaluated by patients, suggesting a promising role of DHT in the self-management of MS.","PeriodicalId":513065,"journal":{"name":"Sclerosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139846109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the Therapeutic Options for Multiple Sclerosis in Brazil: A Comprehensive Analysis 绘制巴西多发性硬化症治疗方案图：综合分析

Sclerosis Pub Date : 2024-02-06 DOI: 10.3390/sclerosis2010003

C. S. Desidério, Yago Marcos Pessoa-Gonçalves, R. O. Trevisan, Marlos Aureliano Dias-Sousa, Weslley Guimarães Bovi, Wellington Francisco Rodrigues, Marcos Vinícius da Silva, V. R. Júnior, Carlo José Freire Oliveira

引用次数: 0

Mapping the Therapeutic Options for Multiple Sclerosis in Brazil: A Comprehensive Analysis 绘制巴西多发性硬化症治疗方案图：综合分析

Sclerosis Pub Date : 2024-02-06 DOI: 10.3390/sclerosis2010003

C. S. Desidério, Yago Marcos Pessoa-Gonçalves, R. O. Trevisan, Marlos Aureliano Dias-Sousa, Weslley Guimarães Bovi, Wellington Francisco Rodrigues, Marcos Vinícius da Silva, V. R. Júnior, Carlo José Freire Oliveira

引用次数: 0

Anti-CD20-Triggered Crohn’s-Like Disease with Severe Perianal Involvement in a Patient with Multiple Sclerosis: Case Report, Review of the Literature, and Potential Therapeutic Approach 一名多发性硬化症患者的抗 CD20 诱发的克罗恩病（Crohn's-Like Disease）伴有严重的肛周受累：病例报告、文献综述和潜在治疗方法

Sclerosis Pub Date : 2024-01-16 DOI: 10.3390/sclerosis2010002

A. Quesada-Simó, Francisco Giner, Lucas Barea-Moya, Alejandro Garrido-Marin, Alejandro Mínguez, Pilar Nos, Sara Gil-Perotín

引用次数: 0

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