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Portación crónica de VHB, HBeAg negativo
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-02-01 DOI: 10.1038/ncpgasthep0865
Morris Sherman
{"title":"Portación crónica de VHB, HBeAg negativo","authors":"Morris Sherman","doi":"10.1038/ncpgasthep0865","DOIUrl":"https://doi.org/10.1038/ncpgasthep0865","url":null,"abstract":"","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"4 Suppl 2 1","pages":"S10-S12"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81056415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hombre de 42 años con hepatitis B crónica, HBeAg positivo 42岁男性，慢性乙型肝炎，HBeAg阳性
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-02-01 DOI: 10.1038/NCPGASTHEP0864
M. Silva
{"title":"Hombre de 42 años con hepatitis B crónica, HBeAg positivo","authors":"M. Silva","doi":"10.1038/NCPGASTHEP0864","DOIUrl":"https://doi.org/10.1038/NCPGASTHEP0864","url":null,"abstract":"","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"4 1","pages":"S7-S9"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87490201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducci|[oacute]|n
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-02-01 DOI: 10.1038/NCPGASTHEP0862
A. Gadano
{"title":"Introducci|[oacute]|n","authors":"A. Gadano","doi":"10.1038/NCPGASTHEP0862","DOIUrl":"https://doi.org/10.1038/NCPGASTHEP0862","url":null,"abstract":"","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77430377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuevas estrategias de tratamiento en la hepatitis B crónica 慢性乙型肝炎的新治疗策略
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-02-01 DOI: 10.1038/NCPGASTHEP0863
Morris Sherman
{"title":"Nuevas estrategias de tratamiento en la hepatitis B crónica","authors":"Morris Sherman","doi":"10.1038/NCPGASTHEP0863","DOIUrl":"https://doi.org/10.1038/NCPGASTHEP0863","url":null,"abstract":"","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86399853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tratamiento de la hepatitis B grave en el contexto del pre y pos trasplante hepático 肝移植前后严重乙型肝炎的治疗
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-02-01 DOI: 10.1038/ncpgasthep0866
Morris Sherman
{"title":"Tratamiento de la hepatitis B grave en el contexto del pre y pos trasplante hepático","authors":"Morris Sherman","doi":"10.1038/ncpgasthep0866","DOIUrl":"https://doi.org/10.1038/ncpgasthep0866","url":null,"abstract":"","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"77 1","pages":"S13-S15"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90941825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging strategies for pegylated interferon combination therapy. 聚乙二醇化干扰素联合治疗的新策略。
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-01-01 DOI: 10.1038/ncpgasthep0691
Eugene R Schiff
{"title":"Emerging strategies for pegylated interferon combination therapy.","authors":"Eugene R Schiff","doi":"10.1038/ncpgasthep0691","DOIUrl":"https://doi.org/10.1038/ncpgasthep0691","url":null,"abstract":"<p><p>Several advances afford promise for improving the management of hepatitis C virus (HCV) infection. Current therapies primarily target the immune system; the now proven ability to culture the entire virus in vitro could ultimately facilitate the identification of therapies directly targeting viral replication. Several therapies are presently in development. Taribavirin hydrochloride (Viramidine, Valeant Pharmaceutical International, Singapore), a ribavirin prodrug, has shown promise, although the rate of sustained virologic response with this agent has been disappointing. The next generation of antivirals will consist of protease and polymerase inhibitors, a number of which are undergoing investigation, initially as monotherapy and subsequently in combination with pegylated interferon and ribavirin. Challenges include the prevention of recurrent HCV infection in liver-transplant recipients and development of a safe and effective HCV vaccine.</p>","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"4 Suppl 1 ","pages":"S17-21"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpgasthep0691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26499293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
New paradigms in the management of hepatitis C virus co-infections. 丙型肝炎病毒合并感染管理的新模式。
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-01-01 DOI: 10.1038/ncpgasthep0692
Kenneth E Sherman
{"title":"New paradigms in the management of hepatitis C virus co-infections.","authors":"Kenneth E Sherman","doi":"10.1038/ncpgasthep0692","DOIUrl":"https://doi.org/10.1038/ncpgasthep0692","url":null,"abstract":"<p><p>Liver disease has emerged as a major contributor to morbidity and mortality in patients with HIV infection. Hepatitis C virus (HCV) infection is a key element in the etiology of liver-associated injury in this population. Increased rates of fibrotic progression have been described and are mediated by alcohol use, the severity of immunosuppression, the use of antiretroviral therapy, and other factors. Large clinical trials have demonstrated the efficacy of treatment with pegylated interferon plus ribavirin and highlighted issues related to management of patients with HIV/HCV co-infection. Although treatment for HCV infection in this group remains a challenge, achievement of a sustained virologic response is feasible in approximately 35% of patients. Treatment must be individualized and attention must be paid to the potential for drug-drug interactions.</p>","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"4 Suppl 1 ","pages":"S10-6"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpgasthep0692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26499292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Customizing treatment to patient populations. 针对患者群体定制治疗方案。
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-01-01 DOI: 10.1038/ncpgasthep0693
Robert S Brown
{"title":"Customizing treatment to patient populations.","authors":"Robert S Brown","doi":"10.1038/ncpgasthep0693","DOIUrl":"https://doi.org/10.1038/ncpgasthep0693","url":null,"abstract":"<p><p>Combination treatment with pegylated interferon plus ribavirin is the most effective therapy for patients with chronic hepatitis C virus (HCV); however, responses are less than optimal in some subpopulations of patients. Emerging insights are suggesting that viral kinetics can be used to predict response. The rapidity of response has been shown to be a more important predictor of sustained virologic response than the duration of therapy. In patients with HCV genotype 2 or 3, shorter durations of treatment might be sufficient in rapid responders and could minimize the risk of toxic effects. Weight-based dosing of ribavirin has emerged as another important consideration. This strategy seems to be most important for difficult-to-treat patients with HCV genotype 1 or advanced fibrosis, and for African-Americans, and is possibly important for patients who have genotype 3 and a high viral load. Re-treatment of nonresponders with interferon-based therapy has been associated with low rates of sustained virologic response. Consensus interferon might offer a new option for patients who do not achieve an early treatment response to standard or pegylated interferon plus ribavirin.</p>","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"4 Suppl 1 ","pages":"S3-9"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpgasthep0693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26499294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Introduction: advances in antiviral therapy for chronic hepatitis C infection—the influence of genotype and HIV co-infection 前言:慢性丙型肝炎病毒感染的抗病毒治疗进展——基因型和HIV合并感染的影响
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2007-01-01 DOI: 10.1038/NCPGASTHEP0690
E. Schiff
{"title":"Introduction: advances in antiviral therapy for chronic hepatitis C infection—the influence of genotype and HIV co-infection","authors":"E. Schiff","doi":"10.1038/NCPGASTHEP0690","DOIUrl":"https://doi.org/10.1038/NCPGASTHEP0690","url":null,"abstract":"","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"230 1","pages":"S1-S2"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76561187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment of chronic hepatitis B 治疗慢性乙型肝炎
Nature Clinical Practice. Gastroenterology & Hepatology Pub Date : 2005-01-04 DOI: 10.24871/6120059-15
P. Pramita, R. Gani, A. Sulaiman
{"title":"Treatment of chronic hepatitis B","authors":"P. Pramita, R. Gani, A. Sulaiman","doi":"10.24871/6120059-15","DOIUrl":"https://doi.org/10.24871/6120059-15","url":null,"abstract":"Chronic hepatitis B is still a major health problem in Indonesia. Unfortunately, to date, treatment of chronic HBV (Hepatitis B virus) infection had not shown satisfactory Result. Monotherapy with alpha interferon or lamivudine have been widely used as treatment of chronic HBV. However, treatment response to Alpha interferon in Asian people was not satisfactory (15% - 20%), while monotherapy with lamivudine was not sufficient to eradicate HBV in chronically infected patients and commonly induce drug resistance. The occurrence of chronic hepatitis B resistant to lamivudine had encouraged development of newer agents such as adefovir, entecavir, emtricitabine and nucleoside analog. New therapeutic strategy using combination therapy should be considered if there is no sufficient response to monotherapy. Keywords : Treatment, chronic hepatitis B, combination therapy","PeriodicalId":51267,"journal":{"name":"Nature Clinical Practice. Gastroenterology & Hepatology","volume":"42 1","pages":"67-68"},"PeriodicalIF":0.0,"publicationDate":"2005-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75572713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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