Interdisciplinary Medicine最新文献

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Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis 植物来源的细胞外囊泡样颗粒作为新的骨合成代谢剂：激活骨形态发生蛋白2/Smads信号轴，促进绝经后骨质疏松症的骨再生

Interdisciplinary Medicine Pub Date : 2026-01-15 DOI: 10.1002/inmd.70086

Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao

{"title":"Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis","authors":"Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao","doi":"10.1002/inmd.70086","DOIUrl":"https://doi.org/10.1002/inmd.70086","url":null,"abstract":"Abstract Postmenopausal osteoporosis, marked by diminished bone regenerative capacity and elevated fracture risk, urgently requires innovative osteoanabolic strategies. Plant‐derived extracellular vesicle (PDEV)‐like particles (EVLPs) have emerged as promising therapeutic candidates due to their bioactive cargo and cross‐kingdom regulatory potential. Building on the traditional use of Dipsaci Radix (DR) in bone repair, this study investigates DR‐derived EVLPs (DREVLPs) as novel bone‐forming nanotherapeutics. We successfully isolated and characterized DREVLPs, demonstrating their remarkable osteogenic capacity through bone morphogenetic protein 2 (BMP2) pathway activation. In bone marrow mesenchymal stem cells (BMSCs), DREVLPs significantly upregulated RUNX2 and collagen I while triggering the BMP2/Smads signaling phosphorylation cascade. Oral administration in ovariectomized mice revealed precise skeletal targeting with DREVLPs preferentially accumulating in femurs and BMSCs. Treatment substantially preserved trabecular architecture, increasing bone volume fraction compared with untreated controls. Molecular analyses confirmed pathway activation through elevated BMP2, p‐Smad1/5/9, and osteogenic markers in bone tissue—effects comparable to clinical bisphosphonates but through anabolic rather than anti‐resorptive mechanisms. These findings establish plant EVLPs as a new category of bone‐forming agents, with DREVLPs representing a translatable oral nanotherapy that addresses the critical unmet need for safe anabolic treatments in postmenopausal osteoporosis through targeted activation of endogenous BMP2 signaling.","PeriodicalId":511595,"journal":{"name":"Interdisciplinary Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inmd.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection 结核分枝杆菌感染过程中不同细胞死亡模式下的宿主-病原体对话

Interdisciplinary Medicine Pub Date : 2024-02-07 DOI: 10.1002/inmd.20230044

Hongxia Ruan, Mengyuan Lyu, Hongli Lai, Lu Niu, Zhenzhen Zhao, Tangyuheng Liu, Shuting Lei, B. Ying

{"title":"Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection","authors":"Hongxia Ruan, Mengyuan Lyu, Hongli Lai, Lu Niu, Zhenzhen Zhao, Tangyuheng Liu, Shuting Lei, B. Ying","doi":"10.1002/inmd.20230044","DOIUrl":"https://doi.org/10.1002/inmd.20230044","url":null,"abstract":"Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug‐resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a role in determining immune outcomes. Several studies have established a strong correlation between cell death and TB progression. This review explores the molecular mechanisms of various cell death modes in Mycobacterium tuberculosis (Mtb) infection and how Mtb's virulence effectors regulate these pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis. Furthermore, therapeutic strategies targeting cell death pathways have shown promising results in TB treatment. Importantly, this review highlights the significant potential of mitochondria in mediating communication between different cell death modes and influencing the final outcomes. Overall, this work provides a comprehensive summary of the role of cell death in host immune responses and immune evasion by Mtb. It also offers valuable insights into the pathogenesis of TB and immune evasion strategies employed by Mtb and contributes to the development of more effective anti‐TB therapies.","PeriodicalId":511595,"journal":{"name":"Interdisciplinary Medicine","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139796973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy 从草药制剂中提取的纳米粒子可能代表一种新型核酸疗法

Interdisciplinary Medicine Pub Date : 2024-02-02 DOI: 10.1002/inmd.20230029

Tingle Feng, Waqas Ahmed, Talha Ahmed, Lukui Chen

引用次数: 0