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New insights into ornidazole-induced male reproductive toxicity in rats associated with perturbations in energy metabolism 奥硝唑诱导的与能量代谢紊乱相关的大鼠雄性生殖毒性的新见解

Toxicology Research Pub Date : 2026-07-11 DOI: 10.1093/toxres/tfag060

Qiujian Feng, Jun Guo, Xuefan Jiang, Zhuozhi Gong, Xiaojing An, Bin Yan, Shengjing Liu

{"title":"New insights into ornidazole-induced male reproductive toxicity in rats associated with perturbations in energy metabolism","authors":"Qiujian Feng, Jun Guo, Xuefan Jiang, Zhuozhi Gong, Xiaojing An, Bin Yan, Shengjing Liu","doi":"10.1093/toxres/tfag060","DOIUrl":"https://doi.org/10.1093/toxres/tfag060","url":null,"abstract":"Abstract Ornidazole (ORN) can induce male reproductive toxicity, but its pathological features and metabolic mechanisms remain incompletely defined. In this study, approved by the Institutional Animal Care and Use Committee of Xiyuan Hospital (No. 2021XLC051), 96 six-week-old male Sprague–Dawley rats were randomly assigned to eight groups, including six ORN-treated groups and two vehicle controls. ORN was administered orally at 200, 400, or 800 mg/kg/day for 14 or 28 days. The 14-day regimen evaluated early epididymal sperm effects, whereas the 28-day regimen assessed broader spermatogenic injury. Body weight, reproductive organ indices, sperm parameters, sex hormones, histopathology, ultrastructure, and targeted energy metabolomics of testicular and epididymal tissues were examined. No obvious reproductive toxicity was observed after 14 days of exposure or after 28 days at 200 mg/kg. However, 400 mg/kg for 28 days significantly reduced sperm motility with minimal histopathological changes, increased luteinizing hormone (LH), and decreased testosterone (T), consistent with asthenozoospermia. In contrast, 800 mg/kg for 28 days markedly decreased sperm concentration and motility, caused prominent testicular and epididymal injury, increased follicle-stimulating hormone (FSH) and LH, and reduced T, consistent with oligoasthenozoospermia. Metabolomic analysis showed that ORN disrupted glycolysis, the tricarboxylic acid cycle, and the pentose phosphate pathway in reproductive tissues, accompanied by altered energy-related metabolites and reduced ATP levels. These findings demonstrate dose-dependent ORN-induced male reproductive toxicity and suggest that perturbation of energy metabolism contributes to impaired sperm motility and spermatogenesis, providing experimental models and mechanistic insight for drug-induced male reproductive injury and future toxicological risk assessment studies.","PeriodicalId":510657,"journal":{"name":"Toxicology Research","volume":"15 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The adjuvant effect of oil-based gastric lavage on the outcome of acute Aluminum phosphide poisoning: a systematic review and meta-analysis 油性洗胃对急性磷化铝中毒结果的辅助作用：系统回顾和荟萃分析

Toxicology Research Pub Date : 2024-03-01 DOI: 10.1093/toxres/tfae029

Omar De Santi, Marcelo Orellana, C. A. Di Niro, H. Lashin, Vanina Greco

{"title":"The adjuvant effect of oil-based gastric lavage on the outcome of acute Aluminum phosphide poisoning: a systematic review and meta-analysis","authors":"Omar De Santi, Marcelo Orellana, C. A. Di Niro, H. Lashin, Vanina Greco","doi":"10.1093/toxres/tfae029","DOIUrl":"https://doi.org/10.1093/toxres/tfae029","url":null,"abstract":"\u0000 \u0000 \u0000 Aluminum Phosphide (AlP) poisoning constituted the most common cause of poisoning death in some low- and middle-income countries (LMICs). This study aimed to evaluate the safety and efficacy of oil-based gastric lavage (GL) compared with standard therapy for the treatment of AlP poisoning. Materials and methods. This systematic review complied with “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” (PRISMA) Protocols. A comprehensive search was carried out, identifying randomized controlled trials (RCTs), including anyone presenting within 6 h of exposure to AlP, and the administration of GL with oils, including liquid paraffin or coconut oil.\u0000 \u0000 \u0000 \u0000 We identified 7 RCTs. The evidence from 4 RCTs indicates that GL with paraffin oil is an effective treatment for acute AlP poisoning, decreasing the mortality rate (RR = 0.62; 95% CI = 0.48 to 0.81; participants = 226; I 2 = 10%; low-quality evidence). We estimate the Number Needed to Treat of 4. Likewise, this intervention reduces the need for intubation and mechanical ventilation (RR = 0.62; 95% CI = 0.40 to 0.79; I2 = 0%; low-quality evidence). Regarding GL with coconut oil, the evidence from 4 RCTs, indicates a slight reduction in mortality (RR = 0.82; 95% CI = 0.69 to 0.98; participants = 112; I2 = 0%; very low-quality evidence).\u0000 \u0000 \u0000 \u0000 Limited evidence suggests that GL with paraffin oil is effective in reducing the mortality rate. Likewise, limited evidence showed in favor of paraffin oil concerning the need for intubation and mechanical ventilation. Very limited evidence suggests that GL with coconut oil could reduce mortality. Both interventions would have a benign safety profile.\u0000","PeriodicalId":510657,"journal":{"name":"Toxicology Research","volume":" March","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0