MedNEXT Journal of Medical and Health Sciences最新文献

{"title":"Major clinical outcomes of the relationship of metabolic syndrome with the success of dental implants: the systematic review","authors":"Graziele Bertoldo Lopes da Silva, Hiago Silva Mendes Brasileiro, Isabela Fernanda Furlan, Álvaro José Cicareli, F. Idalgo","doi":"10.54448/mdnt24s102","DOIUrl":"https://doi.org/10.54448/mdnt24s102","url":null,"abstract":"Introduction: Studies show that around 55% of dental implants can be affected by peri-implantitis, a chronic inflammatory process induced by bacteria, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around the implants. implants. Current evidence points to an increased risk of developing peri-implantitis in both obesity/metabolic syndrome (MS) and diabetes mellitus (DM) conditions compared to the healthy population. Objective: It was to develop a systematic review to present the main clinical outcomes of the relationship between metabolic syndrome and the success of dental implants. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from October to December 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 92 articles were found, 26 articles were evaluated in full and 19 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 14 studies with a high risk of bias and 12 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=53.5%>50%. It was concluded that there is a correlation between the presence of metabolic syndrome and a higher prevalence of some bacterial species in the peri-implant groove, regardless of the peri-implant status. Metabolic syndrome has been shown to significantly reduce bone formation in the periimplant area in the short term. Metabolic syndrome and diabetes mellitus represent an increased risk of developing peri-implantitis. Peri-implantitis requires treatment to induce new bone formation around an implant. However, this is challenging as peri-implantitis, particularly in obese or diabetic conditions, has a microenvironment that is characterized by increased inflammation.","PeriodicalId":510380,"journal":{"name":"MedNEXT Journal of Medical and Health Sciences","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major clinical outcomes of the relationship of metabolic syndrome with the success of dental implants: the systematic review","authors":"Graziele Bertoldo Lopes da Silva, Hiago Silva Mendes Brasileiro, Isabela Fernanda Furlan, Álvaro José Cicareli, F. Idalgo","doi":"10.54448/mdnt24s102","DOIUrl":"https://doi.org/10.54448/mdnt24s102","url":null,"abstract":"Introduction: Studies show that around 55% of dental implants can be affected by peri-implantitis, a chronic inflammatory process induced by bacteria, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around the implants. implants. Current evidence points to an increased risk of developing peri-implantitis in both obesity/metabolic syndrome (MS) and diabetes mellitus (DM) conditions compared to the healthy population. Objective: It was to develop a systematic review to present the main clinical outcomes of the relationship between metabolic syndrome and the success of dental implants. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from October to December 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 92 articles were found, 26 articles were evaluated in full and 19 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 14 studies with a high risk of bias and 12 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=53.5%>50%. It was concluded that there is a correlation between the presence of metabolic syndrome and a higher prevalence of some bacterial species in the peri-implant groove, regardless of the peri-implant status. Metabolic syndrome has been shown to significantly reduce bone formation in the periimplant area in the short term. Metabolic syndrome and diabetes mellitus represent an increased risk of developing peri-implantitis. Peri-implantitis requires treatment to induce new bone formation around an implant. However, this is challenging as peri-implantitis, particularly in obese or diabetic conditions, has a microenvironment that is characterized by increased inflammation.","PeriodicalId":510380,"journal":{"name":"MedNEXT Journal of Medical and Health Sciences","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major clinical outcomes of the use of biostimulators (L-PRF and coenzyme Q10) in the optimization of buccomaxillofacial surgery: a systematic review","authors":"Patricia Consuelo Nacimba Medina, Brian Steven López, I. Beneti","doi":"10.54448/mdnt24110","DOIUrl":"https://doi.org/10.54448/mdnt24110","url":null,"abstract":"Introduction: Tissue engineering combines three key elements matrix (three-dimensional structures that support growth, collagen cell, bone mineral), signaling molecules (growth factors (GF) and leukocyte cytokines), and cells (osteoblasts, fibroblasts or other adequate populations for tissue regeneration. Many studies suggest that antioxidants act as inhibitors of osteoclastogenesis and the inhibitory effect of CoQ10 on osteoclast differentiation. These findings highlight the potential therapeutic applications of CoQ10 for the treatment of bone diseases. Objective: The present study highlighted the main approaches to the use of fibrin-rich plasma (L-PRF) and coenzyme Q10 in buccomaxillofacial surgery through a systematic review. Methods: The systematic review rules of the PRISMA Platform were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2006 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed accordingly, according to the Cochrane instrument. Results and Conclusion: A total of 104 articles were found, 38 articles were evaluated and 23 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 36 studies with a high risk of bias and 20 studies that did not meet GRADE. The use of platelet and leukocyte-rich fibrin can reduce bone absorption, infection, pain, local edema, and wound healing. L-PRF presents itself as an autogenous biomaterial with great versatility, low cost, easy acquisition and wide use, and infinite possibilities. It can be combined with other materials in the most diverse areas of dentistry. Also, CoQ10 concentrations can suppress ROS, which is needed as a signaling intermediate. CoQ10 acts as an enhancer of all stages of osteoblastic differentiation. Thus, CoQ10 suppresses osteoclast differentiation by eliminating generated intracellular ROS. Furthermore, CoQ10 enhances bone regeneration in all differentiation processes through transcription factor activity.","PeriodicalId":510380,"journal":{"name":"MedNEXT Journal of Medical and Health Sciences","volume":"5 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major clinical outcomes of the use of biostimulators (L-PRF and coenzyme Q10) in the optimization of buccomaxillofacial surgery: a systematic review","authors":"Patricia Consuelo Nacimba Medina, Brian Steven López, I. Beneti","doi":"10.54448/mdnt24110","DOIUrl":"https://doi.org/10.54448/mdnt24110","url":null,"abstract":"Introduction: Tissue engineering combines three key elements matrix (three-dimensional structures that support growth, collagen cell, bone mineral), signaling molecules (growth factors (GF) and leukocyte cytokines), and cells (osteoblasts, fibroblasts or other adequate populations for tissue regeneration. Many studies suggest that antioxidants act as inhibitors of osteoclastogenesis and the inhibitory effect of CoQ10 on osteoclast differentiation. These findings highlight the potential therapeutic applications of CoQ10 for the treatment of bone diseases. Objective: The present study highlighted the main approaches to the use of fibrin-rich plasma (L-PRF) and coenzyme Q10 in buccomaxillofacial surgery through a systematic review. Methods: The systematic review rules of the PRISMA Platform were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2006 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed accordingly, according to the Cochrane instrument. Results and Conclusion: A total of 104 articles were found, 38 articles were evaluated and 23 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 36 studies with a high risk of bias and 20 studies that did not meet GRADE. The use of platelet and leukocyte-rich fibrin can reduce bone absorption, infection, pain, local edema, and wound healing. L-PRF presents itself as an autogenous biomaterial with great versatility, low cost, easy acquisition and wide use, and infinite possibilities. It can be combined with other materials in the most diverse areas of dentistry. Also, CoQ10 concentrations can suppress ROS, which is needed as a signaling intermediate. CoQ10 acts as an enhancer of all stages of osteoblastic differentiation. Thus, CoQ10 suppresses osteoclast differentiation by eliminating generated intracellular ROS. Furthermore, CoQ10 enhances bone regeneration in all differentiation processes through transcription factor activity.","PeriodicalId":510380,"journal":{"name":"MedNEXT Journal of Medical and Health Sciences","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}