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European Journal of Medicinal Chemistry最新文献

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Inhibition of the thioredoxin system for radiosensitization therapy of cancer 抑制硫氧还蛋白系统用于癌症放射增敏疗法
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116218
Yisheng Cao, Xiedong Zhou, Qiuying Nie, Junmin Zhang
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引用次数: 0
Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle 抗癌药物发现中的大环和大环化：拼图的重要组成部分
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116234
Chao Zhang, Fenfen Liu, Youming Zhang, Chun Song
{"title":"Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle","authors":"Chao Zhang, Fenfen Liu, Youming Zhang, Chun Song","doi":"10.1016/j.ejmech.2024.116234","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116234","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"91 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare flavanone-diarylheptanoid hybrids from Typha angustifolia shows anti breast cancer activity via activating TGF-β1/Smad signaling pathway 通过激活 TGF-β1/Smad 信号通路，从香蒲中提取的稀有黄酮-二芳基庚烷类杂交化合物具有抗乳腺癌活性
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116220
Yu-Peng Li, Hu Liu, Xue-Chun Zhao, Xue-Lian Tang, Peipei Shan, Hua Zhang
{"title":"Rare flavanone-diarylheptanoid hybrids from Typha angustifolia shows anti breast cancer activity via activating TGF-β1/Smad signaling pathway","authors":"Yu-Peng Li, Hu Liu, Xue-Chun Zhao, Xue-Lian Tang, Peipei Shan, Hua Zhang","doi":"10.1016/j.ejmech.2024.116220","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116220","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"47 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel aminothiazoximone-corbelled ethoxycarbonylpyrimidones with antibiofilm activity to conquer Gram-negative bacteria through potential multitargeting effects 具有抗生物膜活性的新型氨噻唑肟酮-共轭乙氧羰基嘧啶酮，通过潜在的多靶点效应征服革兰氏阴性菌
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116219
Wei Li, Xi Yang, Nisar Ahmad, Shao-Lin Zhang, Cheng-He Zhou
{"title":"Novel aminothiazoximone-corbelled ethoxycarbonylpyrimidones with antibiofilm activity to conquer Gram-negative bacteria through potential multitargeting effects","authors":"Wei Li, Xi Yang, Nisar Ahmad, Shao-Lin Zhang, Cheng-He Zhou","doi":"10.1016/j.ejmech.2024.116219","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116219","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"31 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The BTLA-HVEM complex – The future of cancer immunotherapy BTLA-HVEM 复合物--癌症免疫疗法的未来
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116231
Karolina Wojciechowicz, M. Spodzieja, Anna Wardowska
{"title":"The BTLA-HVEM complex – The future of cancer immunotherapy","authors":"Karolina Wojciechowicz, M. Spodzieja, Anna Wardowska","doi":"10.1016/j.ejmech.2024.116231","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116231","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"48 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of FLT3-targeting PROTACs with potent antiproliferative activity against acute myeloid leukemia cells harboring FLT3 mutations 发现对携带 FLT3 突变的急性髓性白血病细胞具有强效抗增殖活性的 FLT3 靶向 PROTACs
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116237
Zhijie Wang, Xun Lu, Canlin Liu, Fei Huang, Tao Lu, Yadong Chen, Lifei Liu, Shuai Lu
{"title":"Discovery of FLT3-targeting PROTACs with potent antiproliferative activity against acute myeloid leukemia cells harboring FLT3 mutations","authors":"Zhijie Wang, Xun Lu, Canlin Liu, Fei Huang, Tao Lu, Yadong Chen, Lifei Liu, Shuai Lu","doi":"10.1016/j.ejmech.2024.116237","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116237","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"94 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139822898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemistry and pharmacological aspects of furanoid cannabinoids and related compounds: Is furanoid cannabinoids open a new dimension towards the non-psychoactive cannabinoids? 呋喃类大麻素及相关化合物的化学和药理学方面：呋喃类大麻素是否为非精神活性大麻素开辟了新天地？
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116164
Radhika Anand, Ritu Painuli, Vijay Kumar, Parvinder Pal Singh
{"title":"Chemistry and pharmacological aspects of furanoid cannabinoids and related compounds: Is furanoid cannabinoids open a new dimension towards the non-psychoactive cannabinoids?","authors":"Radhika Anand, Ritu Painuli, Vijay Kumar, Parvinder Pal Singh","doi":"10.1016/j.ejmech.2024.116164","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116164","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"25 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139888982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer 靶向胰岛素样生长因子 2 mRNA 结合蛋白（IGF2BPs）治疗癌症
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116241
Yuanqian Cai, Yingzhe Wang, Bingjie Mao, Qidong You, Xiaoke Guo
{"title":"Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer","authors":"Yuanqian Cai, Yingzhe Wang, Bingjie Mao, Qidong You, Xiaoke Guo","doi":"10.1016/j.ejmech.2024.116241","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116241","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"137 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139828191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds 噻二唑、硒二唑和三唑融合的蒽醌类 G-四链路靶向抗癌化合物
European Journal of Medicinal Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.ejmech.2024.116222
Daria V. Andreeva, Tatiyana S. Vedekhina, Alexander S. Gostev, L. Dezhenkova, Yulia L. Volodina, Alina A. Markova, Minh Tuan Nguyen, Olga S. Ivanova, Vladislava А. Dolgusheva, Anna M. Varizhuk, A. Tikhomirov, A. Shchekotikhin
{"title":"Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds","authors":"Daria V. Andreeva, Tatiyana S. Vedekhina, Alexander S. Gostev, L. Dezhenkova, Yulia L. Volodina, Alina A. Markova, Minh Tuan Nguyen, Olga S. Ivanova, Vladislava А. Dolgusheva, Anna M. Varizhuk, A. Tikhomirov, A. Shchekotikhin","doi":"10.1016/j.ejmech.2024.116222","DOIUrl":"https://doi.org/10.1016/j.ejmech.2024.116222","url":null,"abstract":"","PeriodicalId":508946,"journal":{"name":"European Journal of Medicinal Chemistry","volume":"25 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139872420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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