Egyptian Society of Clinical Toxicology Journal最新文献

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Evaluation of Toxic Effects of Caffeinated Energy Drinks on Thyroid Gland of Adult Male Albino Rats: Assessment of Apoptosis and Regeneration 评估含咖啡因能量饮料对成年雄性白化大鼠甲状腺的毒性作用：评估细胞凋亡和再生

Egyptian Society of Clinical Toxicology Journal Pub Date : 2024-06-01 DOI: 10.21608/esctj.2024.288750.1058

N. Elrewieny, R. Eltokhy, H. Aboubakr, Passant Essam Eldin Shibel, S. Alsaeed

{"title":"Evaluation of Toxic Effects of Caffeinated Energy Drinks on Thyroid Gland of Adult Male Albino Rats: Assessment of Apoptosis and Regeneration","authors":"N. Elrewieny, R. Eltokhy, H. Aboubakr, Passant Essam Eldin Shibel, S. Alsaeed","doi":"10.21608/esctj.2024.288750.1058","DOIUrl":"https://doi.org/10.21608/esctj.2024.288750.1058","url":null,"abstract":"Background: Young adults and adolescents are rarely aware of the negative effects of caffeinated energy beverages. Aim of the work: to investigate the hazards of caffeinated energy drinks on the thyroid gland in albino rats by biochemical, histological, and immunohistochemical examinations, and examining the signs of the apoptosis/regeneration rate. Material and methods: 24 adult albino rats were classified into 3 groups; Group 1 were kept on basal diet and distilled water, Group 2 and Group 3 were given energy drinks in 2 different doses for 14 days. Rats in Group 2 were given a daily low dose of caffeinated energy drinks daily (10 mg/kg), while the Group 3 of rats were given a daily high dose of caffeinated energy drinks (20 mg/kg). Finally, T3, T4 and TSH were measured, histopathology and immunohistochemical study using ki-67 and caspase-3 were performed. Results: the mean free T3 and T4 in (groups 1, 2 and 3) showed statistically significant higher values. There was a significant difference regarding ki-67 in the 3 studied groups; the mean ki-67 score showed the highest value in group 3 followed by the control group and group 2 respectively, while there was a non-significant difference regarding caspase 3 in the 3 studied groups. Conclusion: oral consumption of energy drinks was associated with significantly overexpression of Ki-67 in thyroid gland suggesting a proliferative response to thyroid gland injury and significant increase in free t3 and t4 in group 2.","PeriodicalId":508932,"journal":{"name":"Egyptian Society of Clinical Toxicology Journal","volume":"24 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Mechanisms of Clozapine-Induced Pancreatic Damage and its Modulation by L-Carnitine in a Rat Model 大鼠模型中氯氮平诱发胰腺损伤的分子机制及其左旋肉碱的调节作用

Egyptian Society of Clinical Toxicology Journal Pub Date : 2024-06-01 DOI: 10.21608/esctj.2024.291423.1060

D. Mesallam, Eman Ahmed Alaa El-Din, Mai Said Ibrahim, Samaa Salah Abd El-Fatah, E. Megahed

{"title":"Molecular Mechanisms of Clozapine-Induced Pancreatic Damage and its Modulation by L-Carnitine in a Rat Model","authors":"D. Mesallam, Eman Ahmed Alaa El-Din, Mai Said Ibrahim, Samaa Salah Abd El-Fatah, E. Megahed","doi":"10.21608/esctj.2024.291423.1060","DOIUrl":"https://doi.org/10.21608/esctj.2024.291423.1060","url":null,"abstract":"Background: Clozapine (CLZ) has been considered the mainstay drug in treatment of resistant schizophrenia. Diabetes mellitus has befallen during clozapine therapy. L-carnitine (LC) has protective effects against many health hazards. Aim of the work: This experiment aimed to examine the molecular mechanisms of pancreatic insult caused by CLZ in rats and the possible ameliorating effect of LC against that toxicity. Material and Methods: Thirty-five adult male albino rats were allocated into five groups equally: control groups (negative and vehicle), LC-treated group received 350 mg/kg/day LC, CLZ-treated group gavaged 25 mg/kg/day CLZ and the combined group gavaged LC+CLZ in the same previous doses. All treatments were given orally for 4 weeks. Results: CLZ-treatment triggered a significant rise in the mean values of body weight (BW) and serum of fasting blood glucose (FBG), amylase, insulin, Triglyceride Glucose (TyG) Index and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Also, a significant upsurge in lipid peroxidation and pro-inflammatory (Nuclear Factor Kappa-light-chain-enhancer of activated B cells (NF-kB)) accompanying by a significant decrease of catalase (CAT), Hemo oxygenase-1 (HO-1) enzyme and nuclear factor erytheroid 2-related factor (Nrf2) activities and anti-inflammatory (IL-10), and decreased expression of Peroxisome proliferator activated receptor alfa (PPAR-α) in pancreatic tissues has occurred.","PeriodicalId":508932,"journal":{"name":"Egyptian Society of Clinical Toxicology Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0