Journal of Experimental Pharmacology最新文献

Acute and Chronic Oral Toxicity of Hydroethanolic Extract of Sclerocarya birrea (Anacardiaceae) in Wistar Rats 硬叶桦木（Anacardiaceae）水乙醇提取物对 Wistar 大鼠的急性和慢性口服毒性

Journal of Experimental Pharmacology Pub Date : 2024-07-01 DOI: 10.2147/jep.s467920

Abdul Gafar Victoir Coulidiaty, Saamou Isaac Boni, Raogo Ouedraogo, B. Koama, Harouna Soré, Roland Nâg-Tiero Meda, Téné Marceline Yaméogo, Estelle Noëla Hoho Youl

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Evaluation of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia abyssinica in Mice [LETTER] 评估阿比西尼亚蒿叶和茎水提取物对小鼠体内泻药作用 [信函]

Journal of Experimental Pharmacology Pub Date : 2024-04-01 DOI: 10.2147/JEP.S470683

Siti Aliyah, Rizky Yulion, Santi Perawati

{"title":"Evaluation of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia abyssinica in Mice [LETTER]","authors":"Siti Aliyah, Rizky Yulion, Santi Perawati","doi":"10.2147/JEP.S470683","DOIUrl":"https://doi.org/10.2147/JEP.S470683","url":null,"abstract":"We have closely read the recent article titled “Evaluation of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia abyssinica in Mice” by Ayele et al. 1 Interestingly, according to our searches, there is limited research available on the Aqueous Leaf and Stem Extracts of Artemisia abyssinica (A. abyssinica) . Most previous studies have focused on the antibacterial and antioxidant effect of A. abyssinica using crude extracts and essential oils. Hence, this study is likely the first evaluation of the laxative effects of Aqueous Leaf and Stem Extracts of A. abyssinica . This study used a method to prepare aqueous leaves and stems of A. abyssinica extracts by heating a plant in 0.8L of distilled water in a 1:1 ratio. Sorita et al (2023) highlighted the benefits of using aqueous extracts, such as minimizing the reliance on organic solvents, reducing expenses, and lowering energy consumption. 2 Based on the results of this article, aqueous leaf and stem extracts of A. abyssinica have demonstrated laxative activity, specifically loperamide-induced constipation. The standard drugs (Castor oil) and bisacodyl used in this study also increased the wet fecal content and frequency of defecation. Ikarashi et al showed that the laxative effect of","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"347 ","pages":"173 - 174"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Evaluation of Diuretic Activity of Aqueous and Hydro Methanolic Crude Extracts and Solvent Fraction of the Hydromethanolic Flower Extract of Erica Arborea L. (Ericaceae) in Swiss Albino Mice 瑞士白化小鼠对 Erica Arborea L.（Ericaceae）水提取物、水甲醇粗提取物和水甲醇花提取物溶剂馏分利尿活性的评估

Journal of Experimental Pharmacology Pub Date : 2024-04-01 DOI: 10.2147/JEP.S453578

Nardos Wondimu, Mestayet Mengistie, J. Yesuf

{"title":"Evaluation of Diuretic Activity of Aqueous and Hydro Methanolic Crude Extracts and Solvent Fraction of the Hydromethanolic Flower Extract of Erica Arborea L. (Ericaceae) in Swiss Albino Mice","authors":"Nardos Wondimu, Mestayet Mengistie, J. Yesuf","doi":"10.2147/JEP.S453578","DOIUrl":"https://doi.org/10.2147/JEP.S453578","url":null,"abstract":"Purpose To evaluate the diuretic effects of aqueous (AQ) and hydromethanolic crude extract (HM) the as well as the solvent fractions of the HM extract from Erica arborea flowers in mice. Methods Mice were administered AQ and HM crude extracts, along with solvent fractions of HM extracts of E. arborea flowers, including HXF (n-hexane fraction), EAF (ethyl acetate fraction), and AQF (aqueous fraction), at doses ranging from 100 to 400 mg/kg orally. The effects of these extracts and solvent fractions on urine and salt excretion over 5 hours were compared to the effects of the solvent used for reconstitution and a standard drug (furosemide 10 mg/kg), as well as to each other. Results The HM crude extract at a lower dose (100 mg/kg) significantly increased urine volume and salt excretion starting from the 3rd h compared to the AQ crude extract. Similar effects were observed for EAF. Notably, the HM extract and its EAF at 400 mg/kg showed comparable urine and salt excretion profiles to the standard drug. Conclusion This study demonstrated that HM extract and EAF promote better diuresis, likely due to their saluretic properties. Furthermore, it confirms the diuretic activity of Erica arborea flowers.","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"1211 1","pages":"175 - 187"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Investigation and in vitro Antimicrobial and Antioxidant Activities Evaluation of Erianthemum aethiopicum Wiens and Polhill Erianthemum aethiopicum Wiens and Polhill 的植物化学研究及体外抗菌和抗氧化活性评价

Journal of Experimental Pharmacology Pub Date : 2024-02-01 DOI: 10.2147/jep.s452098

Teshome Gonfa, A. Temesgen, Tsegu Kiros, S. Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu

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Phytochemical Investigation and in vitro Antimicrobial and Antioxidant Activities Evaluation of Erianthemum aethiopicum Wiens and Polhill Erianthemum aethiopicum Wiens and Polhill 的植物化学研究及体外抗菌和抗氧化活性评价

Journal of Experimental Pharmacology Pub Date : 2024-02-01 DOI: 10.2147/jep.s452098

Teshome Gonfa, A. Temesgen, Tsegu Kiros, S. Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu

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The Effects of Potato (Solanum tuberosum L. vs. Granola; Solanaceae) Peel Extract Gel on Gingival Wound Healing in Wistar Rats 马铃薯（茄科植物）果皮提取凝胶对 Wistar 大鼠牙龈伤口愈合的影响

Journal of Experimental Pharmacology Pub Date : 2024-01-01 DOI: 10.2147/jep.s443355

Faradila Tiarasanti, I. Sufiawati, Eri Amalia, Kartika Sari, Cucu Zubaedah, Veni Takarini

引用次数: 0