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Journal of Geriatric Neurology最新文献

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A case of refractory myasthenia gravis in the elderly demonstrating remission following rituximab therapy 一例接受利妥昔单抗治疗后病情得到缓解的难治性老年肌无力病例
Journal of Geriatric Neurology Pub Date : 2024-07-03 DOI: 10.53991/jgn.2024.00136
W. Jeong, Min Ju Kang
{"title":"A case of refractory myasthenia gravis in the elderly demonstrating remission following rituximab therapy","authors":"W. Jeong, Min Ju Kang","doi":"10.53991/jgn.2024.00136","DOIUrl":"https://doi.org/10.53991/jgn.2024.00136","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune disorder characterized by antibodies against acetylcholine receptors at the neuromuscular junction, leading to various symptoms such as muscle weakness, fatigue, and ptosis. While MG traditionally affects young women in their 30s, recent trends indicate an increasing incidence in the elderly population regardless of gender. Diagnosis and management of MG in the elderly pose challenges due to diverse presentations and higher risks of complications from standard treatments. Rituximab, an immunosuppressive agent, has shown efficacy in refractory MG cases, offering a promising therapeutic option. Here, we present a case of an 82-year-old female with Alzheimer dementia who presented with generalized weakness, ultimately diagnosed with MG. Despite initial treatment with immunoglobulin and subsequent relapse, rit-uximab therapy led to significant improvement in symptoms and functional status. Our case un-derscores the diagnostic challenges and therapeutic complexities of MG in the elderly and highlights rituximab as a valuable treatment option.","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elderly care system of Sweden 瑞典的老年人护理系统
Journal of Geriatric Neurology Pub Date : 2024-06-12 DOI: 10.53991/jgn.2023.00115
Youngsoon Choi, So Yoon Kim
{"title":"Elderly care system of Sweden","authors":"Youngsoon Choi, So Yoon Kim","doi":"10.53991/jgn.2023.00115","DOIUrl":"https://doi.org/10.53991/jgn.2023.00115","url":null,"abstract":"","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"116 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term care services for the elderly and the brain lesion disability system in South Korea 韩国的老年人长期护理服务和脑损伤残疾制度
Journal of Geriatric Neurology Pub Date : 2024-06-11 DOI: 10.53991/jgn.2024.00129
Kyum-Yil Kwon
{"title":"Long-term care services for the elderly and the brain lesion disability system in South Korea","authors":"Kyum-Yil Kwon","doi":"10.53991/jgn.2024.00129","DOIUrl":"https://doi.org/10.53991/jgn.2024.00129","url":null,"abstract":"","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"39 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
False-negative interferon-γ release assay result in an elderly patient with tuberculous meningitis 一名老年结核性脑膜炎患者的干扰素-γ释放测定结果呈假阴性
Journal of Geriatric Neurology Pub Date : 2023-12-15 DOI: 10.53991/jgn.2023.00108
Sung Chul Lim, Juhee Oh, Jeonghyun Park, Sanghyun Kim, Jusuck Lee
{"title":"False-negative interferon-γ release assay result in an elderly patient with tuberculous meningitis","authors":"Sung Chul Lim, Juhee Oh, Jeonghyun Park, Sanghyun Kim, Jusuck Lee","doi":"10.53991/jgn.2023.00108","DOIUrl":"https://doi.org/10.53991/jgn.2023.00108","url":null,"abstract":"Tuberculous meningitis (TBM) is the most severe manifestation of extra-pulmonary tuberculosis, and has high morbidity and mortality. Therefore early treatment, which is empirical therapy, is essential to improve the clinical prognosis of TBM. But rapid diagnosis remains a challenge due to non-specific symptoms, low sensitivity and time-comsuming diagnostic tests. Mycobacterium tuberculosis antigen specific interferon-γ release assay (IGRA) is widely considered as an adjunctive test to confirm latent tuberculous infection or to support the diagnosis of active tuberculous infection. However, elderly patients with TBM have been shown to have a higher rate of false negative IGRA results than patients with tuberculosis at other sites. We report a case of TBM with a negative IGRA test for M. tuberculosis antigen.","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"409 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of medication use with increased fall risk in inpatients: a single-center matched study 住院患者用药与跌倒风险增加的关系：一项单中心匹配研究
Journal of Geriatric Neurology Pub Date : 2023-12-15 DOI: 10.53991/jgn.2023.00094
Hae-Jin Jeon, Eun-Joo Choi, Min-Jung Kim, Ae-Hee Jung, Sun-Hoi Jung, Hyo-Nam Woo, Kyu-Nam Heo, Ju-Yeun Lee, Hyung-Min Kwon
{"title":"Association of medication use with increased fall risk in inpatients: a single-center matched study","authors":"Hae-Jin Jeon, Eun-Joo Choi, Min-Jung Kim, Ae-Hee Jung, Sun-Hoi Jung, Hyo-Nam Woo, Kyu-Nam Heo, Ju-Yeun Lee, Hyung-Min Kwon","doi":"10.53991/jgn.2023.00094","DOIUrl":"https://doi.org/10.53991/jgn.2023.00094","url":null,"abstract":"Background: Evaluation of drug-induced fall risk is often neglected in clinical practice. The purpose of this study was to analyze the effects of medication use on falls in hospitalized elderly patients. Methods: This was a retrospective case-control study. A total of 1,020 patients were evaluated who were 60 years and over and admitted between January 1st and December 31, 2021. Patients aged 60 years and over with reports of fall accidents in 2021 were included in the fall group. Cases were matched 1:4 on sex, age, medical department, and Morse Fall Scale (MFS) score to randomly selected control from patients with no falls. Demographics, MFS score, physical examination, and medication profile were collected from electronic medical records. Data were analyzed by chi-square test and multiple logistic regression analysis.Results: After adjustment for age, sex, medical department, MFS score and Charlson comorbidity index, hemoglobin level, sodium level, ambulatory aid, gait/transferring (impaired), mental status, polypharmacy (10 and more), use of anxiolytics, antipsychotics, opioids, and anticholinergics were significantly associated with falls. On multiple regression analysis, hemoglobin level, ambulatory aid (furniture), use of anxiolytics, and opioids were significantly associated with falls in every model. Conclusions: The type of medication, especially anxiolytics and opioids, was more significantly associated with increased risk of falls than polypharmacy. It is suggested to be aware of the effects of medication on falls and evaluate medication use on a regular basis.","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"337 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of sudden cardiac arrest after carotid artery stenting in a patient with acute myocardial infarction 一例急性心肌梗死患者颈动脉支架植入术后心脏骤停的病例
Journal of Geriatric Neurology Pub Date : 2023-11-27 DOI: 10.53991/jgn.2023.00059
Hokyu Kim, Minkyung Kim, J. Han, H. Kim, Chi Kyung Kim, K. Oh, Keon-Joo Lee
{"title":"A case of sudden cardiac arrest after carotid artery stenting in a patient with acute myocardial infarction","authors":"Hokyu Kim, Minkyung Kim, J. Han, H. Kim, Chi Kyung Kim, K. Oh, Keon-Joo Lee","doi":"10.53991/jgn.2023.00059","DOIUrl":"https://doi.org/10.53991/jgn.2023.00059","url":null,"abstract":"","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139233046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Numb chin syndrome as the first manifestation of an advanced metastatic cancer 作为晚期转移性癌症首发症状的下巴麻木综合征
Journal of Geriatric Neurology Pub Date : 2023-11-27 DOI: 10.53991/jgn.2023.00080
Soei Ann, B. Suh
{"title":"Numb chin syndrome as the first manifestation of an advanced metastatic cancer","authors":"Soei Ann, B. Suh","doi":"10.53991/jgn.2023.00080","DOIUrl":"https://doi.org/10.53991/jgn.2023.00080","url":null,"abstract":"","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive insight into common urinary problems in older adults 全面了解老年人常见的泌尿问题
Journal of Geriatric Neurology Pub Date : 2023-11-24 DOI: 10.53991/jgn.2023.00087
Sung-Tae Cho, Ha Ri Na
{"title":"Comprehensive insight into common urinary problems in older adults","authors":"Sung-Tae Cho, Ha Ri Na","doi":"10.53991/jgn.2023.00087","DOIUrl":"https://doi.org/10.53991/jgn.2023.00087","url":null,"abstract":"","PeriodicalId":508255,"journal":{"name":"Journal of Geriatric Neurology","volume":"368 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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