Journal of IVF-Worldwide最新文献

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Artificial intelligence model utilizing endometrial analysis to contribute as a predictor of assisted reproductive technology success 人工智能模型利用子宫内膜分析预测辅助生殖技术的成功率

Journal of IVF-Worldwide Pub Date : 2024-04-24 DOI: 10.46989/001c.115893

Ricardo H. Asch Schuff, Jorge Suarez, Nicolas Laugas, Marlene L. Zamora Ramirez, Tamar Alkon

{"title":"Artificial intelligence model utilizing endometrial analysis to contribute as a predictor of assisted reproductive technology success","authors":"Ricardo H. Asch Schuff, Jorge Suarez, Nicolas Laugas, Marlene L. Zamora Ramirez, Tamar Alkon","doi":"10.46989/001c.115893","DOIUrl":"https://doi.org/10.46989/001c.115893","url":null,"abstract":"This study addresses the development of EndoClassify, an artificial intelligence (AI) model designed to assess endometrial characteristics and enhance embryo receptivity. Utilizing a dataset of 402 endometrial ultrasound images augmented to 14.989, EndoClassify, incorporating Attention U-Net for image segmentation and GoogLeNet Inception for image classification, demonstrated exceptional performance with an accuracy of 95%, loss of 10%, a sensitivity of 93%, and specificity of 93%. The significance of EndoClassify extends beyond its robust metrics. This AI model has transformative potential in clinical settings, offering specialists a reliable, rapid, and accurate tool for endometrial assessment in assisted reproduction technology (ART) cycles. Identifying ‘good endometrium’ with 71% accuracy, corresponding to a 74% pregnancy rate, underscores EndoClassify’s role in significantly improving patient outcomes. In conclusion, the seamless integration of ultrasonographic parameters and AI techniques enhances efficiency in clinical decision-making and signifies a crucial collaboration between advanced technology and clinical expertise. While acknowledging the retrospective design as a limitation, it is imperative to highlight potential biases introduced by this design. Additionally, including fresh and frozen embryo transfers without known ploidy status adds transparency to the study’s limitations. EndoClassify stands as a beacon of progress, poised to revolutionize personalized treatment strategies and bring tangible benefits to specialists and patients in the dynamic landscape of assisted reproductive technology.","PeriodicalId":508169,"journal":{"name":"Journal of IVF-Worldwide","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Impact of Long-Term GnRH Agonist Therapy on Pregnancy Outcomes in Endometriosis-Associated Implantation Failure and Pregnancy Loss 评估长期 GnRH 激动剂疗法对子宫内膜异位症相关种植失败和妊娠损失患者妊娠结局的影响

Journal of IVF-Worldwide Pub Date : 2024-03-28 DOI: 10.46989/001c.115593

Masato Kobanawa

{"title":"Evaluating the Impact of Long-Term GnRH Agonist Therapy on Pregnancy Outcomes in Endometriosis-Associated Implantation Failure and Pregnancy Loss","authors":"Masato Kobanawa","doi":"10.46989/001c.115593","DOIUrl":"https://doi.org/10.46989/001c.115593","url":null,"abstract":"This study aimed to investigate the efficacy of long-term gonadotropin-releasing hormone (GnRH) agonist therapy in preventing endometriosis progression and relieving symptoms, particularly on pregnancy outcomes during thawed embryo transfer in patients experiencing endometriosis and recurrent implantation failure or recurrent pregnancy loss. In individuals with clinical endometriosis and a history of recurrent implantation failure or recurrent pregnancy loss, we conducted a comparative analysis of clinical outcomes between those undergoing long-term GnRH agonist treatment for symptom relief, such as menstrual pain, followed by embryo transfer using Hormone Replacement Therapy (HRT) cycle, and those undergoing embryo transfer using an HRT cycle without GnRH agonist treatment. The study examined various clinical outcomes between the two groups. The primary outcomes included live birth rate (LBR), miscarriage rate, biochemical pregnancy rate, and perinatal complications. The GnRH agonist group showed significantly higher LBR than the control group (37.50% vs. 13.04%; p=0.02). Multivariable logistic regression analysis, adjusted for age and gravidity, showed significantly higher LBR in the GnRH agonist group compared to the control group (odds ratio: 15.3; 95% confidence interval: 2.30, 102.00; p=0.005). The findings of this study suggested that employing a GnRH agonist in the embryo transfer protocol is effective for patients with endometriosis experiencing recurrent implantation failure or recurrent pregnancy loss.","PeriodicalId":508169,"journal":{"name":"Journal of IVF-Worldwide","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rapidly Changing World of Infertility Practice: Where will it lead to? 瞬息万变的不孕不育实践世界：它将通向何方？

Journal of IVF-Worldwide Pub Date : 2024-01-29 DOI: 10.46989/001c.92514

Center for Human Reproduction, NYC, USA

{"title":"The Rapidly Changing World of Infertility Practice: Where will it lead to?","authors":"Center for Human Reproduction, NYC, USA","doi":"10.46989/001c.92514","DOIUrl":"https://doi.org/10.46989/001c.92514","url":null,"abstract":"This article describes the radical changes in business models driving infertility care since the inception of IVF, which created the impetus for establishing a separate sub-specialty of Reproductive Endocrinology and Infertility (REI). We here describe how this small new sub-specialty area of gynecology over 45 years grew into a highly influential subspecialty and, ultimately, into a true “industry,” supported by ever-larger numbers of provider clinics and, in parallel, an equally quickly growing full-service support industry. With the finance world for several good reasons, discovering fertility as a growth industry, the world has, especially over the last decade, witnessed an acceleration in the pace of change, the largest likely being that only a minority of individual IVF clinic sites in the U.S. are still physician-owned. Throughout the country, but especially in larger cities, it appears that Wall Street has taken over, with large national chains of IVF clinics, mostly owned by private equity, buying up physician-owned clinics at a record pace to compete for market share. How these developments have already greatly affected the provision of fertility services and where they will lead is the topic of this article, with, of course, particular attention to the New York Tristate area.","PeriodicalId":508169,"journal":{"name":"Journal of IVF-Worldwide","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0