Journal of Pediatric Gastroenterology and Nutrition最新文献

Coexisting Th1 and Th2 cytokines in patients with collagenous gastritis and implications for its pathogenesis 胶原性胃炎患者体内并存的 Th1 和 Th2 细胞因子及其对发病机制的影响

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-01-09 DOI: 10.1002/jpn3.12109

Qingqing Liu, Yanping Wang, N. Harpaz

{"title":"Coexisting Th1 and Th2 cytokines in patients with collagenous gastritis and implications for its pathogenesis","authors":"Qingqing Liu, Yanping Wang, N. Harpaz","doi":"10.1002/jpn3.12109","DOIUrl":"https://doi.org/10.1002/jpn3.12109","url":null,"abstract":"Collagenous gastritis (CG) is a rare cause of refractory dyspepsia and anemia that frequently affects children and young adults and whose histological hallmark is chronic mucosal inflammation with a subepithelial collagen band. The etiology remains obscure, and no established treatments exist. We investigated the pathogenesis of CG by determining the expression profiles of genes related to immunity and inflammation in index biopsies.Gastric biopsies from 10 newly diagnosed patients with CG were evaluated using the NanoString nCounter assay. Gastric biopsies from 14 normal individuals served as controls. The gene expression ratios for CG versus controls were determined in pooled samples and confirmed in individual samples by quantitative reverse transcription polymerase chain reaction. The results were compared with previously reported expression data from a cohort of patients with collagenous colitis, a colonic disorder with similar morphology, including subepithelial collagen band.CG biopsies featured enhanced expression of key genes encoding both Th1 (IFNγ, TNF‐α, IL‐2, IL‐10, IL‐12A, IL‐12B, and IL‐18) and Th2 cytokines (IL‐3, IL‐4, IL‐5, IL‐6, and IL‐13). In contrast, biopsies from patients with CC exhibited upregulated Th1 cytokines only.We show in this first published gene expression profiling study that CG involves simultaneous upregulation of Th1 and Th2 cytokines. This finding is unique, contrasting with other types of chronic gastritis as well as with collagenous colitis, which shares the presence of a collagen band. Involvement of Th2 immunity in CG would support further investigation of potential dietary, environmental, or allergic factors to guide future therapeutic trials.","PeriodicalId":508144,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":"53 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Associate Editors' Corner: A quality improvement primer—The why and what, the how, and reasons to publish 副主编园地：质量改进入门--为什么要出版、出版什么、如何出版以及出版的理由

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-01-07 DOI: 10.1002/jpn3.12110

Jeannie S. Huang

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Using social media for patient care, research, and professional development: A North American society of pediatric gastroenterology, hepatology, and nutrition position paper 将社交媒体用于患者护理、研究和职业发展：北美儿科胃肠病学、肝病学和营养学学会立场文件

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-01-07 DOI: 10.1002/jpn3.12051

Jason A. Silverman, Ankur Chugh, J. Hollier, Nicole Martin, V. Raghu, Eduardo Rosas‐Blum, Miranda A. L. van Tilburg, Priya Venkataraman‐Rao, R. Venkatesh, Peter L. Lu

{"title":"Using social media for patient care, research, and professional development: A North American society of pediatric gastroenterology, hepatology, and nutrition position paper","authors":"Jason A. Silverman, Ankur Chugh, J. Hollier, Nicole Martin, V. Raghu, Eduardo Rosas‐Blum, Miranda A. L. van Tilburg, Priya Venkataraman‐Rao, R. Venkatesh, Peter L. Lu","doi":"10.1002/jpn3.12051","DOIUrl":"https://doi.org/10.1002/jpn3.12051","url":null,"abstract":"The advent of social media has changed numerous aspects of modern life, with users developing and maintaining personal and professional relationships, following and sharing breaking news and importantly, searching for and disseminating health information and medical research. In the present paper, we reviewed available literature to outline the potential uses, pitfalls and impacts of social media for providers, scientists and institutions involved in digestive health in the domains of patient care, research and professional development. We recommend that these groups become more active participants on social media platforms to combat misinformation, advocate for patients, and curate and disseminate valuable research and educational materials. We also recommend that societies such as NASPGHAN assist its members in accessing training on effective social media use and the creation and maintenance of public‐facing profiles and that academic institutions incorporate substantive social media contributions into academic promotion processes.","PeriodicalId":508144,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":"65 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Efficacy of infliximab after loss of response of/intolerance to adalimumab in pediatric Crohn's disease: A retrospective multicenter cohort study of the “GETAID pédiatrique” 小儿克罗恩病阿达木单抗失效/不耐受后使用英夫利西单抗的疗效：GETAID pédiatrique "多中心队列回顾性研究

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-01-07 DOI: 10.1002/jpn3.12044

Anne Lecoutour, Claire Dupont, D. Caldari, C. Dumant, Audrey Vanrenterghem, Mathias Ruiz, Rémi Duclaux‐Loras, Stéphanie Berthet, Georges Dimitrov, Delphine Lacroix, Pauline Duvant, Céline Roman, Anne Claire Wagner, Aurélie Bourmaud, Jérôme Viala, F. Ruemmele, B. Pigneur

{"title":"Efficacy of infliximab after loss of response of/intolerance to adalimumab in pediatric Crohn's disease: A retrospective multicenter cohort study of the “GETAID pédiatrique”","authors":"Anne Lecoutour, Claire Dupont, D. Caldari, C. Dumant, Audrey Vanrenterghem, Mathias Ruiz, Rémi Duclaux‐Loras, Stéphanie Berthet, Georges Dimitrov, Delphine Lacroix, Pauline Duvant, Céline Roman, Anne Claire Wagner, Aurélie Bourmaud, Jérôme Viala, F. Ruemmele, B. Pigneur","doi":"10.1002/jpn3.12044","DOIUrl":"https://doi.org/10.1002/jpn3.12044","url":null,"abstract":"Infliximab (IFX) and adalimumab (ADA) are recommended for induction and maintenance of remission in pediatric Crohn's disease (CD). ADA is now often used in first line due to its efficacy and tolerability, but a loss of response (LOR) can occur over time. The aim was to assess the efficacy of IFX as second line therapy after LOR or intolerance to ADA in pediatric CD patients at 1 year.We conducted a retrospective and multicenter study in France among the “GETAID pédiatrique” centers between April 2019 and April 2022. CD patients under 18 years old and treated with IFX after ADA failure or intolerance were included. We collected anthropometric, clinical, and biological data at baseline (start of IFX), at 6 and 12 months. Clinical remission was defined by a Weighted Pediatric CD Activity Index (wPCDAI) score less than 12.5 points.Of the 32 patients included in our study, 27 (84.4%) were still on IFX at 12 months of the switch. Among them, 13 had discontinued ADA because of a LOR, 12 for insufficient response and 2 due to primary nonresponse. At M12, 22 patients were in corticosteroid free clinical remission (68.7%). Under IFX, the wPCDAI decreased over time (47.5 ± 24.1, 16.6 ± 21.2 and 9.7 ± 19.0 at M0, M6 and M12 respectively). The only factor associated with clinical remission at 12 months was absence of perianal disease at the end of the IFX induction.IFX is effective in maintaining remission at 1 year in pediatric CD patients experiencing a LOR or intolerance with ADA, and IFX could be an interesting therapeutic choice instead of other biologics in this situation.","PeriodicalId":508144,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":"29 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impact of early immunosuppression on pediatric liver transplant outcomes within 1 year 早期免疫抑制对小儿肝移植一年内疗效的影响

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-01-02 DOI: 10.1002/jpn3.12112

V. Raghu, Xingyu Zhang, James E Squires, Elizabeth Eisenberg, Amy G. Feldman, Jennifer Halma, Anna L. Peters, R. Gonzalez-Peralta, Vicky L. Ng, Simon Horslen, S. Lobritto, John C. Bucuvalas, G. Mazariegos, E. Perito

{"title":"Impact of early immunosuppression on pediatric liver transplant outcomes within 1 year","authors":"V. Raghu, Xingyu Zhang, James E Squires, Elizabeth Eisenberg, Amy G. Feldman, Jennifer Halma, Anna L. Peters, R. Gonzalez-Peralta, Vicky L. Ng, Simon Horslen, S. Lobritto, John C. Bucuvalas, G. Mazariegos, E. Perito","doi":"10.1002/jpn3.12112","DOIUrl":"https://doi.org/10.1002/jpn3.12112","url":null,"abstract":"The Starzl Network for Excellence in Pediatric Transplantation identified optimizing immunosuppression (IS) as a priority practice improvement area for patients, families, and providers. We aimed to evaluate associations between clinical characteristics, early IS, and outcomes.We analyzed pediatric liver transplant (LT) data from 2013 to 2018 in the United Network for Organ Sharing (UNOS) and the Society of Pediatric Liver Transplantation (SPLIT) registries.We included 2542 LT recipients in UNOS and 1590 in SPLIT. IS choice varied between centers with steroid induction and mycophenolate mofetil (MMF) use each ranging from 0% to 100% across centers. Clinical characteristics associated with early IS choice were inconsistent between the two data sets. T‐cell depleting antibody use was associated with improved 1‐year graft (hazard ratio [HR] 0.50, 95% confidence interval [CI] 0.34−0.76) and patient (HR 0.40, 95% CI 0.20−0.79) survival in UNOS but decreased 1‐year patient survival (HR 4.12, 95% CI 1.31−12.93) and increased acute rejection (HR 1.58, 95% CI 1.07−2.34) in SPLIT. Non‐T‐cell depleting antibody use was not associated with differential risk of survival nor rejection. MMF use was associated with improved 1‐year graft survival (HR 0.73, 95% CI 0.54−0.99) in UNOS only.Variation exists in center choice of early IS regimen. UNOS and SPLIT data provide conflicting associations between IS and outcomes in multivariable analysis. These results highlight the need for future multicenter collaborative work to identify evidence‐based IS best practices.","PeriodicalId":508144,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":"24 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0