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Thioredoxin-2 protects mice against experimental myocardial infarction 硫氧还蛋白-2 保护小鼠免受实验性心肌梗死的伤害

Redox Experimental Medicine Pub Date : 2024-02-01 DOI: 10.1530/rem-23-0029

T. Medali, Dominique Couchie, Nathalie Mougenot, Maria Mihoc, Olaf Bergmann, Wouter Derks, Celio X. Santos, Bertrand Friguet, Mustapha Rouis

{"title":"Thioredoxin-2 protects mice against experimental myocardial infarction","authors":"T. Medali, Dominique Couchie, Nathalie Mougenot, Maria Mihoc, Olaf Bergmann, Wouter Derks, Celio X. Santos, Bertrand Friguet, Mustapha Rouis","doi":"10.1530/rem-23-0029","DOIUrl":"https://doi.org/10.1530/rem-23-0029","url":null,"abstract":"Introduction and objective: Myocardial infarction (MI), which in general results from complications of atherosclerosis, is characterized by high inflammation and CMs apoptosis and by major loss of cardiomyocytes. Regeneration of these lost CMs represents a major challenge for MI therapy. The increase of mitochondrial reactive oxygen species (ROS) is involved in cell cycle arrest which can be restarted by hypoxia or in the presence of ROS scavengers. Among ROS scavengers, mitochondrial Thioredoxin-2 (Trx-2), an important antioxidant protein, could play a role in the CMs renewal. \u0000\u0000Method: In this study, we investigated the effect of Trx-2 on mouse heart after an experimental MI.\u0000\u0000Results: Trx-2 improves mouse cardiac function, reduces cardiac infarction size and increases the expression of cardiac anti-inflammatory markers. In addition, it reduces apoptosis and oxidative stress in heart tissue of mice after MI but it does not increase CM proliferation in cell culture or in heart tissue. \u0000\u0000Conclusion: Mitochondrial Trx-2 effectively protects against heart infarction, likely via the reduction of oxidative stress, inflammation and apoptosis but not through CM renewal. \u0000\u0000Significance statement: This research unveils the complexities of myocardial infarction (MI) and highlights mitochondrial Thioredoxin-2's (Trx-2) role. Post-MI, marked by inflammation, cardiomyocyte (CM) apoptosis, and significant CM loss. Trx-2 emerges as a vital protector. Its intervention improves mouse cardiac function, reduces infarction size, and fosters an anti-inflammatory environment. By uncovering these mechanisms, the study suggests potential therapeutic strategies for oxidative stress, inflammation, and apoptosis in MI, positioning Trx-2 as a promising candidate for future cardiac interventions.","PeriodicalId":506293,"journal":{"name":"Redox Experimental Medicine","volume":"98 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intake of Palmitic Acid and Its association with Metabolic Flexibility in Middle-Aged Individuals: A Preliminary Study 中年人棕榈酸摄入量及其与代谢灵活性的关系：初步研究

Redox Experimental Medicine Pub Date : 2023-11-01 DOI: 10.1530/rem-23-0022

E. Murru, G. Carta, Claudia Manca, Alessia Leone, Chiara Murru, Michele Ruggiu, Roberto Solinas, Roberta Montisci, Filippo Tocco, S. Banni

{"title":"Intake of Palmitic Acid and Its association with Metabolic Flexibility in Middle-Aged Individuals: A Preliminary Study","authors":"E. Murru, G. Carta, Claudia Manca, Alessia Leone, Chiara Murru, Michele Ruggiu, Roberto Solinas, Roberta Montisci, Filippo Tocco, S. Banni","doi":"10.1530/rem-23-0022","DOIUrl":"https://doi.org/10.1530/rem-23-0022","url":null,"abstract":"Background: Disparities in data regarding the health effects of dietary fats may arise from the distinct roles various dietary fatty acids play in metabolic flexibility (MF). Objective: This study aimed to assess the relationship between dietary palmitic acid (PA) intake and its association with body fat deposition and MF in middle-aged healthy individuals. Methods: Fifteen healthy participants (n=15; 6 males, 9 females) with a mean age of 54 were enlisted. They were subjected to graded exercise tests using a cycle ergometer coupled with a calorimeter. Respiratory gas exchange was evaluated to determine two MF parameters. First, the MF index (MFI) was derived by multiplying peak fatty acid oxidation (PFO) per kg of fat-free mass (FFM) with the percentage of VO2max at PFO. The second parameter, Peak Energy Substrates’ Oxidation (PESO), was computed by aggregating the kilocalories from PFO and Peak Carbohydrate Oxidation (PCO), normalized per kg FFM. Dietary intake was gauged using a 7-day dietary record. Spearman’s regression was employed to analyze the association between dietary intake of specific fat classes, PA, MF parameters, and body fat percentage. Results: Preliminary results demonstrate that dietary saturated fatty acids (SFA) within physiological limits correlate with enhanced substrate oxidation capacity. This suggests augmented MF in middle-aged subjects. Among dietary SFAs, PA was identified as the primary factor in this favorable correlation. Conclusions: Our initial observations, even though preliminary, strongly suggest a beneficial association between PA intake, MF, and body fat percentage. This underscores the potential nutritional importance of PA in promoting MF.","PeriodicalId":506293,"journal":{"name":"Redox Experimental Medicine","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0