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Long-Term Functional Limitations and Predictors of Recovery after COVID-19: A Multicenter Prospective Cohort Study. COVID-19 后的长期功能限制和康复预测因素：多中心前瞻性队列研究。

The American Journal of Medicine Pub Date : 2024-06-01 DOI: 10.2139/ssrn.4768427

Marla K. Beauchamp, R. Kirkwood, MyLinh Duong, T. Ho, P. Raina, R. Kruisselbrink, A. Jones, C. Girolametto, A. Costa

{"title":"Long-Term Functional Limitations and Predictors of Recovery after COVID-19: A Multicenter Prospective Cohort Study.","authors":"Marla K. Beauchamp, R. Kirkwood, MyLinh Duong, T. Ho, P. Raina, R. Kruisselbrink, A. Jones, C. Girolametto, A. Costa","doi":"10.2139/ssrn.4768427","DOIUrl":"https://doi.org/10.2139/ssrn.4768427","url":null,"abstract":"BACKGROUND\u0000Limited data exist on post-severe COVID-19 functional trajectory, particularly considering premorbid status. We characterized 1-year functional recovery post-hospitalization for COVID-19, highlighting predictors of long-term recovery.\u0000\u0000\u0000METHODS\u0000We enrolled adult patients with lab-confirmed SARS-CoV-2 infection and hospitalized for COVID-19 sequelae, from five major Ontario, Canada hospitals in a prospective cohort study. Assessments included telephone interviews on admission followed by telephone and in-person assessments at 3-, 6-, 9-, and 12-months post-discharge. The Activity-Measure for Post-Acute Care (AM-PAC) Mobility and Cognition scales were administered at baseline and every 3 months for 1 year. Secondary outcomes included symptoms, spirometry, physical performance, dyspnea, fatigue, distress, anxiety and depression, and quality of life.\u0000\u0000\u0000RESULTS\u0000254 patients (57.1% male) with a mean age of 60.0 (±13.1) years and an average hospital stay of 14.3 (±19.7) days agreed to participate. At 12 months, 55.3% demonstrated clinically important deficits in mobility and 38.8% had cognitive deficits compared to premorbid levels. Fatigue was reported in 44.2%, followed by difficulty walking long distances in 35.8% and dyspnea in 33.0%. Almost 40% of patients had an FEV1(% Pred) < 80% at 12 months, 60.3% had impairments in physical performance, and 44.5% had problems with anxiety or depression. Predictors of better mobility at 12 months included higher premorbid mobility status, male sex, shorter hospital stay, fewer comorbidities, and higher FEV1 (% pred) at the 3-month follow-up.\u0000\u0000\u0000CONCLUSIONS\u0000Our study provides compelling evidence of the long-term impact of COVID-19 on functional and cognitive status 1-year post-infection.","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"110 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort. 长期 COVID 特征和经验：耶鲁大学 LISTEN 研究队列的描述性研究。

The American Journal of Medicine Pub Date : 2024-04-01 DOI: 10.1016/j.amjmed.2024.04.015

Mitsuaki Sawano, Yilun Wu, Rishi M. Shah, Tianna Zhou, Adith Arun, Pavan Khosla, Shayaan Kaleem, Anushree Vashist, Bornali Bhattacharjee, Qinglan Ding, Yuan Lu, C. Caraballo, Frederick Warner, Chenxi Huang, Jeph Herrin, David Putrino, Teresa Michelsen, Liza Fisher, Cynthia Adinig, Akiko Iwasaki, H. Krumholz

引用次数: 0