The Journal of infection最新文献

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Global antimicrobial resistance and antibiotic use in COVID-19 patients within health facilities: a systematic review and meta-analysis of aggregated participant data. 全球抗菌药耐药性和医疗机构中 COVID-19 患者的抗生素使用情况:对参与者汇总数据的系统回顾和荟萃分析。
The Journal of infection Pub Date : 2024-05-01 DOI: 10.1016/j.jinf.2024.106183
Xinyi Yang, Xiying Li, Shengyue Qiu, Chaojie Liu, Shanquan Chen, Haohai Xia, Yingchao Zeng, Lin Shi, Jie Chen, Jinkun Zheng, Shifang Yang, Guobao Tian, Gordon Liu, Lianping Yang
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引用次数: 0
The Impact of Vaccination and SARS-CoV-2 Variants on the Virological Response to SARS-CoV-2 Infections during the Alpha, Delta, and Omicron waves in England. 疫苗接种和 SARS-CoV-2 变异株对英国阿尔法、德尔塔和奥米克隆波期间 SARS-CoV-2 感染的病毒学反应的影响》(The Impact of Vaccination and SARS-CoV-2 Variants on the Virological Response to SARS-CoV-2 Infections during the Alpha, Delta, and Omicron waves in England.
The Journal of infection Pub Date : 2023-11-01 DOI: 10.2139/ssrn.4445193
Rachel Lunt, Catherine Quinot, Freja Kirsebom, N. Andrews, Catriona Skarnes, Louise Letley, D. Haskins, Catriona Angel, Skye Firminger, Kay Ratcliffe, Shelina Rajan, Angela Sherridan, Samreen Ijaz, M. Zambon, Kevin Brown, M. Ramsay, J. L. Bernal
{"title":"The Impact of Vaccination and SARS-CoV-2 Variants on the Virological Response to SARS-CoV-2 Infections during the Alpha, Delta, and Omicron waves in England.","authors":"Rachel Lunt, Catherine Quinot, Freja Kirsebom, N. Andrews, Catriona Skarnes, Louise Letley, D. Haskins, Catriona Angel, Skye Firminger, Kay Ratcliffe, Shelina Rajan, Angela Sherridan, Samreen Ijaz, M. Zambon, Kevin Brown, M. Ramsay, J. L. Bernal","doi":"10.2139/ssrn.4445193","DOIUrl":"https://doi.org/10.2139/ssrn.4445193","url":null,"abstract":"Vaccination status and the SARS-CoV-2 variant individuals are infected with are known to independently impact viral dynamics; however, little is known about the interaction of these two factors and how this impacts viral dynamics. Here we investigated how monovalent vaccination modified the time course and viral load of infections from different variants. Regression analyses were used to investigate the impact of vaccination on cycle threshold values and disease severity, and interval-censored survival analyses were used to investigate the impact of vaccination on duration of positivity. A range of covariates were adjusted for as potential confounders and investigated for their own effects in exploratory analyses. All analyses were done combining all variants and stratified by variant. For those infected with Alpha or Delta, vaccinated individuals were more likely to report mild disease than moderate/severe disease and had significantly shorter duration of positivity and lower viral loads compared to unvaccinated individuals. Vaccination had no impact on self-reported disease severity, viral load, or duration if positivity for those infected with Omicron. Overall, individuals who were immunosuppressed and clinically extremely vulnerable had longer duration of positivity and higher viral loads. This study adds to the evidence base on disease dynamics following COVID-19, demonstrating that vaccination mitigates severity of disease, the amount of detectable virus within infected individuals and reduces the time individuals are positive for. However, these effects have been significantly attenuated since the emergence of Omicron. Therefore, our findings strengthen the argument for using modified or multivalent vaccines that target emerging variants.","PeriodicalId":505921,"journal":{"name":"The Journal of infection","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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