Breast Cancer: Targets and Therapy最新文献

Research Progress on Ferroptosis and Nanotechnology-Based Treatment in Triple-Negative Breast Cancer 三阴性乳腺癌铁蛋白沉积和基于纳米技术的治疗研究进展

Breast Cancer: Targets and Therapy Pub Date : 2024-07-01 DOI: 10.2147/bctt.s475199

Jun Zhang, Shengjun Zhang, Minli Liu, Zhe Yang, Rong Huang

引用次数: 0

The Prognostic Value of Serum Albumin to Globulin Ratio in Patients with Breast Cancer: A Retrospective Study 乳腺癌患者血清白蛋白与球蛋白比率的预后价值：一项回顾性研究

Breast Cancer: Targets and Therapy Pub Date : 2024-07-01 DOI: 10.2147/bctt.s471747

Chi Pan, Yawen Gu, Qingtao Ni

{"title":"The Prognostic Value of Serum Albumin to Globulin Ratio in Patients with Breast Cancer: A Retrospective Study","authors":"Chi Pan, Yawen Gu, Qingtao Ni","doi":"10.2147/bctt.s471747","DOIUrl":"https://doi.org/10.2147/bctt.s471747","url":null,"abstract":"Objective: This study examined the potential risk value of the serum albumin to globulin ratio (AGR) in patients with breast cancer (BC). Methods: This study employed a retrospective design, enrolling 332 patients with BC and 38 patients without BC treated at Taizhou People’s Hospital between September 2015 and May 2021. Multivariate Cox proportional hazard regression models were used to identify potential risk factors. A prognostic nomogram was developed based on the multivariate analyses. The receiver operating characteristic curve determined the optimal cutoff value for AGR. Results: The results indicated a statistically significant decrease in AGR among patients with BC. Significant disparities were observed in globulin and AGR levels between the two cohorts. AGR was significantly associated with tumor size and stage, with a marked decline in advanced stages of BC. Additionally, AGR and aspartate transaminase/Alanine aminotransferase (AST/ALT) emerged as significant diagnostic indicators for invasive carcinoma and advanced stages (II–IV) of BC. Specifically, AGR exhibited an area under the curve of 0.645 (P < 0.003), highlighting the discriminatory capacity of serum globulin levels in distinguishing between BC and non-BC cohorts. Conclusions: The AGR, routinely assessed due to its simplicity, objectivity, and cost-effectiveness, holds promise as a potential risk factor for BC and may have practical implications in clinical settings.","PeriodicalId":505521,"journal":{"name":"Breast Cancer: Targets and Therapy","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics in Radiotherapy-Induced Early Adverse Skin Reactions of Breast Cancer Patients 放疗诱发乳腺癌患者早期皮肤不良反应的代谢组学研究

Breast Cancer: Targets and Therapy Pub Date : 2024-07-01 DOI: 10.2147/bctt.s466521

Alexandra N. McMahon, Eunkyung Lee, Cristiane Takita, Isildinha Reis, Joanne L. Wright, Jennifer Hu

引用次数: 0

Breast Cancer Adjuvant Radiotherapy in Up-Front to Chemotherapy: Is There a Worthwhile Benefit? A Preliminary Report 乳腺癌化疗前辅助放疗：是否有价值？初步报告

Breast Cancer: Targets and Therapy Pub Date : 2024-07-01 DOI: 10.2147/bctt.s471345

Grazia Lazzari, I. Benevento, A. Montagna, Barbara D'Andrea, Giuseppina De Marco, G. Castaldo, A. Bianculli, Raffaele Tucciariello, V. Metallo, A. Solazzo

引用次数: 0

Analysis of the Value of Quantitative Features in Multimodal MRI Images to Construct a Radio-Omics Model for Breast Cancer Diagnosis 分析多模态核磁共振成像图像中的定量特征的价值以构建乳腺癌诊断的放射线光学模型

Breast Cancer: Targets and Therapy Pub Date : 2024-06-01 DOI: 10.2147/bctt.s458036

Zhitao Zhang, Huan Lan, Shuai Zhao

引用次数: 0

Retrospective Analysis of Pyrotinib-Based Therapy for Metastatic Breast Cancer: Promising Efficacy in Combination with Trastuzumab 基于派罗替尼治疗转移性乳腺癌的回顾性分析：与曲妥珠单抗联用疗效显著

Breast Cancer: Targets and Therapy Pub Date : 2024-05-01 DOI: 10.2147/bctt.s457845

Qingqing Gu, Mingzhi Zhu, Yanyan Wang, Yuanting Gu

引用次数: 0

Expression and Significance of LINC02418 in Breast Cancer LINC02418 在乳腺癌中的表达和意义

Breast Cancer: Targets and Therapy Pub Date : 2024-04-01 DOI: 10.2147/bctt.s454054

Yong-Hong Zhou, Jian-Yuan Huang

{"title":"Expression and Significance of LINC02418 in Breast Cancer","authors":"Yong-Hong Zhou, Jian-Yuan Huang","doi":"10.2147/bctt.s454054","DOIUrl":"https://doi.org/10.2147/bctt.s454054","url":null,"abstract":"Purpose: The complicated pathogenesis and poor prognosis of breast cancer have become a major difficulty in medical research. This study aims to explore new lncRNA as prognostic markers for breast cancer and explore their roles and molecular mechanisms to lay a foundation for the treatment of cancer patients. Patients and Methods: The expression of LINC02418 and miR-766-5p in breast cancer tissues and cells was first identified using polymerase chain reaction, and Pearson was used to examine the correlation between the two. The cancer cells activities under different transfection conditions were detected using the Transwell assay and CCK8 assay. The correlation between LINC02418 and patient prognosis was analyzed using multifactor Cox regression and Kaplan-Meier. Results: It was shown that LINC02418 expression was upregulated in breast cancer tissues and cells. There are significant differences in lymph node metastasis and TNM stage between high and low LINC02418 expression groups. The higher the expression of LINC02418, the higher the mortality rate of breast cancer patients. miR-766-5p expression was downregulated and negatively correlated with LINC02418. There are binding sites between LINC02418 and miR-766-5p; Transfection with miR-766-5p inhibitor boosted LINC02418 luciferase activity, but transfection with miR-766-5p mimic decreased it. Knockdown of LINC02418 promoted miR-766-5p expression and inhibited cancer progression, which was alleviated to some extent by transfection with miR-766-5p inhibitors. Conclusion: LINC02418 has the potential to serve as a poor prognostic marker for breast cancer and plays a pro-oncogenic role by targeting miR-766-5p.","PeriodicalId":505521,"journal":{"name":"Breast Cancer: Targets and Therapy","volume":"95 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Analysis of Digital Mammography, Ultrasonography, and Pathologic Features in Pure Invasive Micropapillary Carcinoma of the Breast (PIMPC) 纯浸润性乳腺微乳头状癌（PIMPC）中数字乳腺 X 射线、超声波和病理特征的相关性分析

Breast Cancer: Targets and Therapy Pub Date : 2024-04-01 DOI: 10.2147/bctt.s454065

Xulei Sui, Peipei Feng, Xiaoyuan Sun, Peng Liang, Ying Liu, Guowei Zhang

引用次数: 0

Clinical Outcomes of Patients with HER2 Positive Metastatic Breast Cancer to the Brain, with First-Line Trastuzumab, Pertuzumab and Chemotherapy, in a Real-World Setting 真实世界中 HER2 阳性脑转移性乳腺癌患者接受一线曲妥珠单抗、泊珠单抗和化疗的临床疗效

Breast Cancer: Targets and Therapy Pub Date : 2024-03-01 DOI: 10.2147/bctt.s439158

S. Sharman Moser, L. Apter, Idit Livnat, Roni Ginsburg, Adva Yarden, Michal Drori, Anat Drizon, G. Chodick, N. Siegelmann-Danieli

引用次数: 0

GNPNAT1 is a Biomarker That Predicts a Poor Prognosis of Breast Cancer GNPNAT1 是预测乳腺癌不良预后的生物标志物

Breast Cancer: Targets and Therapy Pub Date : 2024-03-01 DOI: 10.2147/bctt.s451054

Yuying Zhou, Wu Xue, Xinyu Meng, Adheesh Bhandari, Hanqian Zeng, Rajan Kc, S. Hirachan, Erjie Xia

引用次数: 0