Caries Research最新文献

{"title":"Relationships among cortisol, perceived stress, and dental caries experience in adolescents and young adults.","authors":"Naima Abouseta, Noha Gomaa, Ali Tassi, Abdelbaset A. Elzagallaai, Michael J. Rieder, S. J. Dixon, S. Pani","doi":"10.1159/000539041","DOIUrl":"https://doi.org/10.1159/000539041","url":null,"abstract":"INTRODUCTION\u0000Stress can impact mental and physical health, especially during adolescence and young adulthood. Previous studies have shown that salivary cortisol levels are elevated in both severe dental caries and periodontal disease. The role of stress in periodontal disease has been studied, but the extent of its contribution to dental caries is less well understood, especially in this age group. The present study aimed to assess the association between perceived stress, cortisol levels (in hair and saliva) and overall caries experience of adolescents and young adults aged between 15 and 25 years.\u0000\u0000\u0000METHODS\u0000Hair and saliva samples were obtained from 93 participants (age range=15-25 years) free of periodontal disease. Cortisol concentrations in hair and saliva were determined using a competitive enzyme-linked immunosorbent assay. Participants completed a perceived stress questionnaire and underwent full-mouth oral examination by a calibrated examiner. Dental caries experience was based on the decayed, missing, and filled teeth (DMFT) index. In addition, sociodemographic variables were recorded. Univariate and multivariable binary logistic regressions were used to assess the relationships of interest.\u0000\u0000\u0000RESULTS\u0000There were significantly higher hair cortisol levels (p=0.042) and perceived stress scale (PSS) scores (p=0.026) in individuals with dental caries experience (DMFT≥1) than in those without (DMFT=0). However, there was no significant difference in salivary cortisol concentration (p=0.302). A binary logistic regression revealed that higher hair cortisol levels and greater scores on the perceived stress scale were associated with an increased odds of having experienced dental caries (OR=4.08, 95% CI 1.04, 15.96; OR=1.65, 95% CI 1.04, 2.63; respectively). In contrast, no significant association was found between dental caries and salivary cortisol concentration (OR=0.31, 95% CI 0.02, 4.23). Using multivariable regression models, caries experience was found to be significantly associated with both hair cortisol levels and PSS scores. These associations remained statistically significant even after adjusting for confounding sociodemographic variables.\u0000\u0000\u0000CONCLUSION\u0000In the absence of periodontal disease, hair cortisol levels have a significant association with dental caries experience, whereas salivary cortisol concentrations do not. Hair cortisol levels may reflect the chronic physiological burden imposed by exposure to detrimental stressors.","PeriodicalId":504581,"journal":{"name":"Caries Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Streptococcus mutans biofilm formation and acidogenicity of infant milk formulas for treating cow milk allergy: An in vitro study.","authors":"Navaphan Rattanapakdeekul, J. Lapirattanakul, Orada Tosrisawatkasem, R. Surarit, A. Smutkeeree","doi":"10.1159/000538882","DOIUrl":"https://doi.org/10.1159/000538882","url":null,"abstract":"INTRODUCTION\u0000When infants cannot consume breast milk, the most commonly available alternative milk formula is cow milk-based. Due to a rise in the prevalence of cow milk protein allergy (CMPA) among children, this study aimed to assess the biofilm formation and acidogenicity of cow milk-based formulas as well as milk formulas suggested for children with CMPA.\u0000\u0000\u0000METHODS\u0000Cow milk-based formulas with 0%, 10%, or 18% sucrose added, partially hydrolyzed formula (pHF), extensively hydrolyzed formula (eHF), amino acid-based formula (AAF), and soy-based formulas with 0%, or 11% sucrose added were evaluated. Streptococcus mutans was used as a representative microorganism associated with caries. The acidogenicity after 24-h incubation was assessed by the pH of the formed biofilm and lactic acid formation. Biofilm formation was quantified using crystal violet staining. Additionally, the biofilm characteristics were determined using confocal laser scanning microscopy (CLSM). Comparisons were made among formulas without added sucrose to observe protein-based differences. Furthermore, formulas with different sucrose percentages were compared to explore the impact of sucrose content.\u0000\u0000\u0000RESULTS\u0000When comparing the formulas without added sucrose, the biofilm formation in the cow milk-based formula and pHF were significantly greater than the soy-based formula, eHF, and AAF. In the presence of S. mutans, all formulas reduced the biofilm pH below the critical enamel pH. The cow milk-based formula and AAF showed a significantly lower biofilm pH than the pHF, soy-based, and eHF groups, while the lactic acid production was markedly higher in the cow milk-based formula, pHF and AAF, compared with the eHF and soy-based formula. Adding sucrose into the cow milk-based and soy-based formulas substantially increased biofilm mass. The biofilm pH of the cow milk-based formulas, with or without sucrose, was significantly lower than that of the soy-based formulas. The CLSM indicated distinct biofilm characteristics among the different protein-based formulas, with sucrose supplementation promoting S. mutans aggregation in cow milk-based formula biofilm and increased density and intact biofilm in the soy-based formula.\u0000\u0000\u0000CONCLUSION\u0000All assessed milk formulas had caries-inducing factors, including those without supplemental sucrose. Among them, the eHF demonstrated the least caries-inducing factors, attributed to its minimal biofilm formation and the highest biofilm pH.","PeriodicalId":504581,"journal":{"name":"Caries Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Sense of Coherence and Caries Activity and Caries Experience among Male Adolescents from Southern Brazil: A Cross-Sectional Study.","authors":"N. Lock, M. L. Gazola, P. K. Marquezan, J. E. Zenkner, L. Alves","doi":"10.1159/000538488","DOIUrl":"https://doi.org/10.1159/000538488","url":null,"abstract":"INTRODUCTION\u0000This cross-sectional study assessed the association between sense of coherence (SoC) and caries activity (number of active caries lesions) and caries experience (DMFT index) among 18-19-year-old male adolescents who joined the Brazilian Army as draftees for mandatory military service (n = 507).\u0000\u0000\u0000METHODS\u0000Data collection included a questionnaire (level of education, family income, and tooth brushing frequency), the Brazilian short version of the SoC scale (SOC-13), and clinical caries examination (noncavitated/cavitated, inactive/active). The main predictor variable was SoC, categorized as low, moderate, or high. Poisson regression models were used for statistical analysis.\u0000\u0000\u0000RESULTS\u0000A high SoC was significantly associated with a lower number of active lesions (adjusted rate ratio = 0.85; 95% CI = 0.74-0.98). No association between SoC and DMFT was detected.\u0000\u0000\u0000CONCLUSION\u0000A high SoC was found to be a protective factor to caries activity in this population.","PeriodicalId":504581,"journal":{"name":"Caries Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should We Wait to Brush Our Teeth?: A Scoping Review Regarding Dental Caries and Erosive Tooth Wear.","authors":"Constanza Fernández, Consuelo A Silva-Acevedo, Fernanda Padilla-Orellana, D. Zero, T. S. Carvalho, Adrian Lussi","doi":"10.1159/000538862","DOIUrl":"https://doi.org/10.1159/000538862","url":null,"abstract":"BACKGROUND\u0000Tooth brushing is a universal recommendation. However, the recommendations related to the time of its execution are conflicting, especially when dealing with patients at risk of erosive tooth wear (ETW) or dental caries.\u0000\u0000\u0000SUMMARY\u0000Our objective was to summarize the evidence on the timing of brushing with fluoridated toothpaste in relation to ETW and cariogenic dietary challenges. We conducted a scoping review following the PRISMA-ScR checklist, using three databases searching for in-vivo, in-situ, or in-vitro studies involving human teeth exposed to either a cariogenic or an erosive challenge. Only models including human saliva and fluoride were assessed. Data selection, extraction, and risk of bias analysis were done in duplicate and independently. From 1,545 identified studies, 17 (16 related to ETW and 1 to dental caries) were included. Most evidence (n=10) supported that brushing with a fluoride-containing product does not increase ETW, independent of the moment of brushing. Delaying tooth brushing up to 1 hour (n=4) or individualized recommendations based on the patient's problem (n=2) were less frequent. Only one study reported that brushing pre- or post-meal does not affect Streptococcus mutans counts. Most data was in-situ (n=13), and the overall study quality was judged as sufficient/low risk of bias.\u0000\u0000\u0000KEY MESSAGES\u0000Although the available evidence lacked robust clinical studies, tooth brushing using fluoridated products immediately after an erosive challenge does not increase the risk of ETW and can be recommended, which is in line with recommendations for dental caries prevention. Furthermore, we suggest updating the international guidelines to promote individualized recommendations based on risk factors to prevent either ETW or dental caries.","PeriodicalId":504581,"journal":{"name":"Caries Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of bias and methodological critical appraisal in systematic reviews of non- and micro-invasive caries management for primary and permanent teeth.","authors":"Caroline Mariano Laux, R. Elagami, Adriana Dos Santos, Ana Paula Pires Dos Santos, T. Tedesco, Thais Gimenez, D. Raggio","doi":"10.1159/000537749","DOIUrl":"https://doi.org/10.1159/000537749","url":null,"abstract":"INTRODUCTION\u0000Paediatric dentistry should rely on evidence-based clinical decisions supported by high-quality, unbiased systematic reviews (SRs). Therefore, the purpose of this study was to systematically evaluate the methodological quality and risk of bias of SRs focused on non- and micro-invasive treatment for caries lesions in primary and permanent teeth.\u0000\u0000\u0000METHODS\u0000A comprehensive search was conducted in multiple databases, including MEDLINE/PubMed, Scopus, Web of Science, EMBASE, Epistemonikos, and ProQuest, up to March 2023 to identify relevant systematic reviews (SRs) focused on non- and micro-invasive caries treatment. Two independent reviewers extracted data from the included SRs and assessed the methodological quality and risk of bias using the AMSTAR 2 and ROBIS tools, respectively.\u0000\u0000\u0000RESULTS\u0000A total of 39 SRs were included in the analysis. Among these, 27 SRs (69.2%) were assessed as having critically low methodological quality, 11 SRs (28.2%) were considered to have low methodological quality and only one SR was rated as high-quality. The primary concern identified was the absence of protocol registration before the commencing the study, observed in 33 SR when using the AMSTAR 2 tool. According to the ROBIS tool, 21 studies (53.8%) were categorised as low risk of bias, 10 (25.6%) as high risk and eight (20.5%) as unclear risk of bias.\u0000\u0000\u0000CONCLUSION\u0000Our analysis revealed that SRs focused on non- and micro-invasive treatment for caries in children and adolescents had critically low methodological quality according to the AMSTAR 2 tool but demonstrated a low risk of bias based on the ROBIS tool. These findings highlight the importance of emphasizing prospective protocol registration, clear reporting of statistical analyses, and addressing potential bias implications within this topic. By addressing these issues, we can enhance the quality of SRs and ensure that clinical decisions rely on unbiased and trustworthy evidence. Registry DOI: 10.17605/OSF.IO/AR4MS.","PeriodicalId":504581,"journal":{"name":"Caries Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A right to health-based approach to dental caries: towards a comprehensive control strategy.","authors":"Sarienten Dominique Mollet, David John Manton, Jan Wollgast, B. Toebes","doi":"10.1159/000538459","DOIUrl":"https://doi.org/10.1159/000538459","url":null,"abstract":"BACKGROUND\u0000Health is a matter of human rights and dental caries is the most common non-communicable disease (NCD) globally. Consequently, dental caries is a matter of human rights and its control, particularly prevention, must be a priority. Although largely preventable, this is too often neglected, both in the literature of human rights- and health law, and in dental research. The right to oral health has recently been acknowledged by the World Health Organization (WHO), but it is insufficiently clear what this right entails.\u0000\u0000\u0000SUMMARY\u0000This article introduces a right to health-based narrative in the context of dental caries. The right to health is stipulated in human rights treaties, including the International Covenant on Economic, Social and Cultural Rights (ICESCR) and the Convention on the Rights of the Child (CRC). States that are Parties to these treaties, which are virtually all States globally, are mandated to ensure the enjoyment of individuals' right to the highest attainable standard of health, including oral health.\u0000\u0000\u0000KEY MESSAGES\u0000Dental caries is a matter of human rights. States have binding obligations to address dental caries: they require the regulation of the healthcare system, i.e. the traditional focus on operative care, but also put the regulation of other risk factors on an equal footing, such as the regulation of the living environment and access to fluoride. A right to health-based approach to dental caries thus offers a comprehensive approach to dental caries control, particularly prevention.","PeriodicalId":504581,"journal":{"name":"Caries Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}