Behavioural Neurology最新文献

筛选

英文中文

Machine Learning Based on a Multiparametric and Multiregional Radiomics Signature Predicts Radiotherapeutic Response in Patients with Glioblastoma. 基于多参数和多区域放射组学特征的机器学习预测胶质母细胞瘤患者的放射治疗反应。

IF 2.8

Behavioural Neurology Pub Date : 2020-10-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1712604

Zi-Qi Pan, Shu-Jun Zhang, Xiang-Lian Wang, Yu-Xin Jiao, Jian-Jian Qiu

{"title":"Machine Learning Based on a Multiparametric and Multiregional Radiomics Signature Predicts Radiotherapeutic Response in Patients with Glioblastoma.","authors":"Zi-Qi Pan, Shu-Jun Zhang, Xiang-Lian Wang, Yu-Xin Jiao, Jian-Jian Qiu","doi":"10.1155/2020/1712604","DOIUrl":"https://doi.org/10.1155/2020/1712604","url":null,"abstract":"Methods: The MRI images, genetic data, and clinical data of 152 patients with GBM were analyzed. 122 patients from the TCIA dataset (training set: n = 82; validation set: n = 40) and 30 patients from local hospitals were used as an independent test dataset. Radiomics features were extracted from multiple regions of multiparameter MRI. Kaplan-Meier survival analysis was used to verify the ability of the imaging signature to predict the response of GBM patients to radiotherapy before an operation. Multivariate Cox regression including radiomics signature and preoperative clinical risk factors was used to further improve the ability to predict the overall survival (OS) of individual GBM patients, which was presented in the form of a nomogram.Results: The radiomics signature was built by eight selected features. The C-index of the radiomics signature in the TCIA and independent test cohorts was 0.703 (P < 0.001) and 0.757 (P = 0.001), respectively. Multivariate Cox regression analysis confirmed that the radiomics signature (HR: 0.290, P < 0.001), age (HR: 1.023, P = 0.01), and KPS (HR: 0.968, P < 0.001) were independent risk factors for OS in GBM patients before surgery. When the radiomics signature and preoperative clinical risk factors were combined, the radiomics nomogram further improved the performance of OS prediction in individual patients (C-index = 0.764 and 0.758 in the TCIA and test cohorts, respectively).Conclusion: This study developed a radiomics signature that can predict the response of individual GBM patients to radiotherapy and may be a new supplement for precise GBM radiotherapy.","PeriodicalId":503930,"journal":{"name":"Behavioural Neurology","volume":" ","pages":"1712604"},"PeriodicalIF":2.8,"publicationDate":"2020-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1712604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38577848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8