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A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells 含磺酰胺基团和不含磺酰胺基团的二芳基脲分子对碳酸酐酶 IX 和 XII 的抑制作用及其对乳腺癌细胞影响的比较研究
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107192
Joy Debnath, Dhananjaya Keshamasetthy, Jacob Combs, Katherine Leon, D. Vullo, Abhijit Chatterjee, Robert McKenna, C. Supuran
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引用次数: 0
Cyclic peptide conjugated photosensitizer for targeted phototheranostics of gram-negative bacterial infection 环肽共轭光敏剂用于革兰氏阴性菌感染的靶向光热疗法
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107203
Minghao Wu, Xiangxiang Kong, Huang Li, Yajing Ji, Shipeng He, Yejiao Shi, Honggang Hu
{"title":"Cyclic peptide conjugated photosensitizer for targeted phototheranostics of gram-negative bacterial infection","authors":"Minghao Wu, Xiangxiang Kong, Huang Li, Yajing Ji, Shipeng He, Yejiao Shi, Honggang Hu","doi":"10.1016/j.bioorg.2024.107203","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107203","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"43 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyrano[2,3-b]chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies 吡喃并[2,3-b]铬酮衍生物作为α-葡萄糖苷酶和α-淀粉酶的新型双重抑制剂：设计、合成、生物学评价和硅学研究
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107207
Elnaz Farzaneh, Mohammad Mohammadi, Pooya Raymand, Milad Noori, Sahand Golestani, Sara Ranjbar, Younes Ghasemi, M. Mohammadi‐Khanaposhtani, M. Asadi, Ensieh Nasli Esfahani, Hossein Rastegar, B. Larijani, Mohammad Mahdavi, Parham Taslimi
{"title":"Pyrano[2,3-b]chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies","authors":"Elnaz Farzaneh, Mohammad Mohammadi, Pooya Raymand, Milad Noori, Sahand Golestani, Sara Ranjbar, Younes Ghasemi, M. Mohammadi‐Khanaposhtani, M. Asadi, Ensieh Nasli Esfahani, Hossein Rastegar, B. Larijani, Mohammad Mahdavi, Parham Taslimi","doi":"10.1016/j.bioorg.2024.107207","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107207","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"95 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure-Affinity relationships of novel σ2R/TMEM97 ligands 新型σ2R/TMEM97配体的结构-亲和力关系
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107191
Grant D. Walby, Qi Gu, Hongfen Yang, Stephen F. Martin
{"title":"Structure-Affinity relationships of novel σ2R/TMEM97 ligands","authors":"Grant D. Walby, Qi Gu, Hongfen Yang, Stephen F. Martin","doi":"10.1016/j.bioorg.2024.107191","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107191","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139890550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene Amomum villosum 果实中具有良好抗炎活性的酚类和萜类化合物及其活性二萜的抗炎机理
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107190
Yang Xu, De-juan Sun, Liangliang Xiong, Zhiqi Zhang, Yuxia Li, Kexin Liu, Hua Li, Lixia Chen
{"title":"Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene","authors":"Yang Xu, De-juan Sun, Liangliang Xiong, Zhiqi Zhang, Yuxia Li, Kexin Liu, Hua Li, Lixia Chen","doi":"10.1016/j.bioorg.2024.107190","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107190","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"23 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing microbial metabolite in catalytic cascade synthesis of conjugated oligomers for In-Situ regulation of biological activity 利用微生物代谢物催化级联合成共轭低聚物，实现生物活性的原位调节
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107188
Yuke Li, Yiming Huang, Q. Shen, Wen Yu, Zhiwen Yang, Zhiqiang Gao, Fengting Lv, Haotian Bai, Shu Wang
{"title":"Utilizing microbial metabolite in catalytic cascade synthesis of conjugated oligomers for In-Situ regulation of biological activity","authors":"Yuke Li, Yiming Huang, Q. Shen, Wen Yu, Zhiwen Yang, Zhiqiang Gao, Fengting Lv, Haotian Bai, Shu Wang","doi":"10.1016/j.bioorg.2024.107188","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107188","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"30 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents 二硫异型泛素试剂依次释放相互作用的蛋白质和泛素修饰酶
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107186
Hongyi Cai, Xiangwei Wu, Junxiong Mao, Zebin Tong, Dingfei Yan, Yicheng Weng, Qingyun Zheng
{"title":"Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents","authors":"Hongyi Cai, Xiangwei Wu, Junxiong Mao, Zebin Tong, Dingfei Yan, Yicheng Weng, Qingyun Zheng","doi":"10.1016/j.bioorg.2024.107186","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107186","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expansion of Targeted Degradation by Gilteritinib-Warheaded PROTACs to ALK Fusion Proteins 吉利替尼主导的 PROTAC 将靶向降解扩展至 ALK 融合蛋白
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107204
Hidetomo Yokoo, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu, Nobumichi Ohoka
{"title":"Expansion of Targeted Degradation by Gilteritinib-Warheaded PROTACs to ALK Fusion Proteins","authors":"Hidetomo Yokoo, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu, Nobumichi Ohoka","doi":"10.1016/j.bioorg.2024.107204","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107204","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"21 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139875556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway Nrf1和Nrf2的基因缺失通过对PI3K-AKT-mTOR信号通路的相反调控，导致HepG2细胞新陈代谢的不同重编程
Bioorganic Chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.bioorg.2024.107212
Rongzhen Deng, Yu-ping Zhu, Keli Liu, Qun Zhang, Shaofan Hu, Meng Wang, Yiguo Zhang
{"title":"Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway","authors":"Rongzhen Deng, Yu-ping Zhu, Keli Liu, Qun Zhang, Shaofan Hu, Meng Wang, Yiguo Zhang","doi":"10.1016/j.bioorg.2024.107212","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.107212","url":null,"abstract":"","PeriodicalId":503894,"journal":{"name":"Bioorganic Chemistry","volume":"55 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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