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A method for evaluating the risks of glucose dysregulation in daily life by continuous measurement of glucose excursions under reduced glycemic load: a pilot study 在降低血糖负荷的情况下，通过连续测量血糖偏移量来评估日常生活中血糖失调风险的方法：一项试点研究

Frontiers in Sensors Pub Date : 2024-05-07 DOI: 10.3389/fsens.2024.1382152

Yoshitada Katagiri, Hiromi Ozaku, Katsuhiko Kondo

{"title":"A method for evaluating the risks of glucose dysregulation in daily life by continuous measurement of glucose excursions under reduced glycemic load: a pilot study","authors":"Yoshitada Katagiri, Hiromi Ozaku, Katsuhiko Kondo","doi":"10.3389/fsens.2024.1382152","DOIUrl":"https://doi.org/10.3389/fsens.2024.1382152","url":null,"abstract":"Introduction: Continuous glucose monitoring is essential for the management of patients with metabolic syndromes in their daily lives. However, how metabolic risks are accessed using time-series glucose excursion data for healthy individuals remains unclear.Methods: Thus, this study aimed to present a method for evaluating the risks of glucose dysregulation by analyzing glucose responses under reduced glycemic load using a phytochemical alpha-glucosidase inhibitor. A 14-day pilot trial with healthy adult participants was conducted to demonstrate the validity of the method.Results and Discussion: The results showed that ultradian glucose spike packets with lower heights dominantly appeared under reduced glycemic load, replacing postprandial single-lobe glucose spikes with higher heights. Furthermore, the frequency dominance of ultradian spike packets contributed to the reduction of overall mean glucose excursions during the test period under reduced glycemic load. Based on the time-delay model, it was indicated that glycemic load reduction recovers regular glucose–insulin coupling accompanying ultradian oscillations, thereby contributing to the maintenance of glucose homeostasis. The findings of this study indicate that the frequency ratio between pulsatile spike packets and single-lobe spikes could be a marker for evaluating glucose regulation/dysregulation in healthy adults.","PeriodicalId":503841,"journal":{"name":"Frontiers in Sensors","volume":"61 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusiophoresis: a novel transport mechanism - fundamentals, applications, and future opportunities 扩散电泳：一种新型传输机制--基础、应用和未来机遇

Frontiers in Sensors Pub Date : 2023-11-30 DOI: 10.3389/fsens.2023.1322906

Arkava Ganguly, Benjamin M. Alessio, Ankur Gupta

{"title":"Diffusiophoresis: a novel transport mechanism - fundamentals, applications, and future opportunities","authors":"Arkava Ganguly, Benjamin M. Alessio, Ankur Gupta","doi":"10.3389/fsens.2023.1322906","DOIUrl":"https://doi.org/10.3389/fsens.2023.1322906","url":null,"abstract":"Diffusiophoresis involves the movement of colloidal-scale entities in response to concentration gradients of a solute. It is broadly categorized into two types: passive and active diffusiophoresis. In passive diffusiophoresis, external concentration gradients drive the motion, while in active diffusiophoresis, the colloidal entity itself assists in generating the gradients. In this perspective, we delve into the fundamental processes underlying passive and active diffusiophoresis and emphasize how prevalent both kinds of diffusiophoresis are in colloidal and natural systems. In particular, we highlight the colloidal focusing feature in passive diffusiophoresis and discuss how it underpins the variety of experimental observations and applications such as low-cost zetasizers, water filtration, and biological pattern formation. For active diffusiophoresis, we emphasize the dependence of particle trajectory on its shape and surface heterogeneity, and discuss how this dictates the applications such as drug delivery, removal of microplastics, and self-repairing materials. Finally, we offer insights and ideas regarding future opportunities in diffusiophoresis.","PeriodicalId":503841,"journal":{"name":"Frontiers in Sensors","volume":"19 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139196965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0