Al-Kitab Journal for Pure Sciences最新文献

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The protective role of ascorbic acid on the testis tissue damage induced by paracetamol in albino rats 抗坏血酸对扑热息痛引起的白化大鼠睾丸组织损伤的保护作用

Al-Kitab Journal for Pure Sciences Pub Date : 2024-01-03 DOI: 10.32441/kjps.08.01.p3

Eda M. A. Alshailabi, O. A. Abdalally, Fatimah A. Mohammed

{"title":"The protective role of ascorbic acid on the testis tissue damage induced by paracetamol in albino rats","authors":"Eda M. A. Alshailabi, O. A. Abdalally, Fatimah A. Mohammed","doi":"10.32441/kjps.08.01.p3","DOIUrl":"https://doi.org/10.32441/kjps.08.01.p3","url":null,"abstract":"Ascorbic acid (AA) plays roles in many biological functions, such as participating in the production of collagen by taking a role in proline and lysine hydroxylation. AA works by removing the reactive oxygen species, thus removing the adhesion of neutrophils to endothelium. The present study investigates the protective effects of AA on the testis tissue damage induced by paracetamol in rats. Thirty-two male rats were equally divided into four groups, with eight rats in each. Group (1) regular control group, group (2) was received 500 mg/kg/b.w. of AA orally for two weeks, group (3) was received 500 mg/kg/b.w. of paracetamol orally for two weeks, group (4) was treated with the AA (500 mg/kg/b.w.) and paracetamol (500 mg/kg/b.w.) orally for two weeks. The histopathological investigations of the testis tissues from the paracetamol group showed atrophy and degeneration of seminiferous tubules with an absence of spermatozoa, presence of cell debris, and loss of the Sertoli cells in some seminiferous tubules when compared with control animals. The testis tissues from a protective group showed less damage in the tubules and germ cells when compared with the paracetamol group. This study indicates that AA protects against paracetamol-induced testis damage in adult male rats.","PeriodicalId":503583,"journal":{"name":"Al-Kitab Journal for Pure Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse Applications of β-enaminone Ligands and their Metal Complexes: A Review ‎Article β-烯醌配体及其金属配合物的多样化应用：综述文章

Al-Kitab Journal for Pure Sciences Pub Date : 2023-11-25 DOI: 10.32441/kjps.07.02.p11

Ali Faisal, E. J. Waheed, A. Ahmed

引用次数: 0

Synthesis, Evaluation of anticancer and antimicrobial activities of some Schiff bases derivatives 一些席夫碱衍生物的合成、抗癌和抗菌活性评价

Al-Kitab Journal for Pure Sciences Pub Date : 2023-11-23 DOI: 10.32441/kjps.07.02.p10

Mohammed Alwan Farhan, Wijdan Amer Ibrahim, W. Ali

{"title":"Synthesis, Evaluation of anticancer and antimicrobial activities of some Schiff bases derivatives","authors":"Mohammed Alwan Farhan, Wijdan Amer Ibrahim, W. Ali","doi":"10.32441/kjps.07.02.p10","DOIUrl":"https://doi.org/10.32441/kjps.07.02.p10","url":null,"abstract":"In this research, compound [1,2-Bis-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-ethane-1,2-diol] was used as starting material for synthesis different Schiff's Bases compounds. The fusion of tartaric acid with thiocarbohydrazide produce the compound (C1), the Schiff's bases (C2-C4) were created through the condensation of substances (C1) with different substituted benzaldehydes in presence of glacial acetic acid as catalyst. Thin layer chromatography (TLC) was used to confirm the compounds' purity, and spectroscopic methods were used to infer the compounds' structures (FTIR) and magnetic nuclear resonance spectroscopy (1H-NMR and 13C-NMR). The agar well diffusion method was used to test synthesized compounds for their antibacterial activity against K. pneumonia and S. aureus, and the findings were inconsistent. Target substances were tested for their ability to kill human breast cancer at concentrations of 50 and 100 g/mL. Human muscle tissue HC normal cell line, human cervical cancer Hela cell line, and HePG2 cell line. The results showed that the chemicals had potential cytotoxic activity against the Hela cell line, particularly compound (C4), which had the greatest inhibition at doses of 100 mg/mL among the examined substances","PeriodicalId":503583,"journal":{"name":"Al-Kitab Journal for Pure Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0