BMEMat最新文献 - Book学术

A biomimetic, triggered‐release micelle formulation of methotrexate and celastrol controls collagen‐induced arthritis in mice 甲氨蝶呤和赛拉司琼的生物仿生触发释放胶束制剂可控制小鼠胶原诱导的关节炎

BMEMat Pub Date : 2024-06-10 DOI: 10.1002/bmm2.12104

He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang

{"title":"A biomimetic, triggered‐release micelle formulation of methotrexate and celastrol controls collagen‐induced arthritis in mice","authors":"He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang","doi":"10.1002/bmm2.12104","DOIUrl":"https://doi.org/10.1002/bmm2.12104","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the joints. Herein, we developed a biomimetic formulation via co‐loading the anti‐inflammatory agent Celastrol (Cel) along with the stabilizer Vitamin K (VK) in antirheumatic methotrexate (MTX)‐conjugated Pluronic F127 (F127) micelles. Micelles were then coated with B cell derived membrane, yielding MTX loaded Cel Micelle (CeViM)‐micelle@B, which were investigated for RA treatment. VK, used at levels well within safety margins, was identified as a carrier compound that could stabilize Cel within micelles, increasing the encapsulation efficiency of Cel. In addition, MTX, a front‐line RA therapeutic, was chemically grafted to F127 via a responsive linker sensitive to the chemically reducing environments. As such, CeViM‐micelle@B released pristine MTX in response to the intracellular reducing environments, which combined with Cel to suppress pro‐inflammatory responses. B cell membrane coating enhanced accumulation of CeViM‐micelle@B in joints, leading to a 75% decrease of inflammatory cytokine secretion in vitro, and significantly ameliorated cartilage and bone structures in the collagen‐induced arthritis murine model. Taken together, this biomimetic nanoparticle holds potential as a next‐generation targeted RA treatment.","PeriodicalId":503415,"journal":{"name":"BMEMat","volume":"119 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges 牙科和骨科钛植入物的混合涂层：当前的进展与挑战

BMEMat Pub Date : 2024-06-10 DOI: 10.1002/bmm2.12105

Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Z. Ye

{"title":"Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges","authors":"Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Z. Ye","doi":"10.1002/bmm2.12105","DOIUrl":"https://doi.org/10.1002/bmm2.12105","url":null,"abstract":"Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost, morbidity, and even mortality. This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials. The forms of manufacturing and synthesizing hybrid coatings were first discussed. We then categorize these coatings based on their biological functions: antibacterial coatings, which are essential for preventing difficult‐to‐treat infection; coatings designed to promote osseointegration, crucial for the mechanical stability of implants; coatings that encourage soft tissue attachment, contributing to the overall success and esthetics of implant. We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative, holistic approach for reducing implant complications. The review culminates in a discussion on future directions in the field, emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients. Together, our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.","PeriodicalId":503415,"journal":{"name":"BMEMat","volume":" 865","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal lanthanide nanomaterials: From fundamentals to theranostic applications 光热镧系纳米材料：从基本原理到治疗应用

BMEMat Pub Date : 2024-05-17 DOI: 10.1002/bmm2.12088

Zhuo Li, Jiacheng Gong, Shan Lu, Xingjun Li, Xiaobo Gu, Jin Xu, Jawairia Umar Khan, Dayong Jin, Xueyuan Chen

{"title":"Photothermal lanthanide nanomaterials: From fundamentals to theranostic applications","authors":"Zhuo Li, Jiacheng Gong, Shan Lu, Xingjun Li, Xiaobo Gu, Jin Xu, Jawairia Umar Khan, Dayong Jin, Xueyuan Chen","doi":"10.1002/bmm2.12088","DOIUrl":"https://doi.org/10.1002/bmm2.12088","url":null,"abstract":"Photothermal lanthanide nanomaterials with unique photophysical properties have been innovatively explored for diagnostics and non‐invasive therapies, and hold great promise for precision theranostics. In this review, we start from the basic principles of excited‐state dynamics and provide a thorough comprehension of the main pathways for photothermal conversion in lanthanide nanocrystals. Aspects influencing the photothermal effect such as lanthanide‐doping concentration, particle size, and crystal structure have been fully discussed. Hybrid strategies for the design of efficient lanthanide‐based photothermal agents, including dye sensitization to break the absorption limit and semiconductor combination to add cross‐relaxation pathways, have also been summarized. Furthermore, we highlight the cutting‐edge applications of photothermal lanthanide nanoplatforms with optical diagnosis and temperature feedback in photothermia‐associated theranostics. Lastly, the current challenges and future eﬀorts for clinical applications are proposed. This review is expected to offer a better understanding of photothermal mechanisms and inspire efforts for designing versatile lanthanide theranostic nanoplatforms.","PeriodicalId":503415,"journal":{"name":"BMEMat","volume":"43 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thickening tissue by thinning electrospun scaffolds for skeletal muscle tissue engineering 通过减薄电纺支架增厚组织，用于骨骼肌组织工程

BMEMat Pub Date : 2024-05-15 DOI: 10.1002/bmm2.12084

Shuo Wang, Xinhuan Wang, Minxuan Jia, Wenli Liu, Qi Gu

{"title":"Thickening tissue by thinning electrospun scaffolds for skeletal muscle tissue engineering","authors":"Shuo Wang, Xinhuan Wang, Minxuan Jia, Wenli Liu, Qi Gu","doi":"10.1002/bmm2.12084","DOIUrl":"https://doi.org/10.1002/bmm2.12084","url":null,"abstract":"Electrospun scaffolds with aligned fiber orientation are widely used in tissue engineering, such as muscle, heart, nerve, tendon, and cartilage, due to their ability to guide cell morphology and induce cellular functions. However, the dense fibrous structure of the scaffolds poses a critical obstacle to engineering highly cellular and thick 3D tissues, as it prevents cell infiltration. While many techniques have been developed to increase the pore size of electrospun scaffolds and improve cell infiltration/migration, it often leads to a decrease in direct cell‐cell contact, compromising cell differentiation and tissue maturation. This study presents an alternative approach by reducing the thickness of scaffolds to the cellular scale and stacking or rolling the cell‐scaffold complex into 3D constructs. We devise a series of novel tools to fabricate, characterize, and manipulate ultra‐thin electrospun scaffolds, which demonstrate high reproducibility, resolution, and cellularity. Our study provides a solution to the cell infiltration issue in muscle tissue engineering and is highly versatile, and can be applied to various fields that require structures with high‐resolution gradients in a layered pattern or complex spatial distribution in a rolled pattern.","PeriodicalId":503415,"journal":{"name":"BMEMat","volume":"131 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simple yet effective H2S‐activated fluorogenic probe for precise imaging of hepatitis and arthritis in situ 用于肝炎和关节炎原位精确成像的简单而有效的 H2S 激活型荧光探针

BMEMat Pub Date : 2024-05-09 DOI: 10.1002/bmm2.12086

Weier Liang, Yongning Bian, Animesh Samanta, Xueqian Chen, Xiaohe Yu, Yichen Zheng, Xueyun Gao, Dongdong Su

{"title":"A simple yet effective H2S‐activated fluorogenic probe for precise imaging of hepatitis and arthritis in situ","authors":"Weier Liang, Yongning Bian, Animesh Samanta, Xueqian Chen, Xiaohe Yu, Yichen Zheng, Xueyun Gao, Dongdong Su","doi":"10.1002/bmm2.12086","DOIUrl":"https://doi.org/10.1002/bmm2.12086","url":null,"abstract":"Hepatitis and arthritis are prevalent inflammatory diseases, and the utilization of fluorogenic probes incorporating hydrogen sulfide (H2S) as a crucial mediator of inflammation presents significant opportunities for early detection. However, the poor in vivo biodistribution and limited targeted efficacy of molecule probes for inflammation imaging severely impede their ability to differentiate the extent of inflammation and provide real‐time monitoring of inflammatory levels. Therefore, we developed a highly efficient H2S‐activated near‐infrared (NIR) fluorogenic probe (hCy‐DNP) for real‐time tracking and capturing fluctuations in H2S levels within inflammatory lesions. hCy‐DNP demonstrates an exceptionally sensitive fluorescence response to H2S expression, enabling specific differentiation between various levels of lipopolysaccharide (LPS) ‐stimulated early hepatitis models in situ, while also facilitating visual monitoring for diagnosis and efficacy evaluation of arthritis. Therefore, hCy‐DNP offers an innovative tool for exploring early diagnosis and evaluating treatment effectiveness across diverse inflammatory diseases.","PeriodicalId":503415,"journal":{"name":"BMEMat","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0