Cancer Research Journal最新文献

{"title":"Predictive and Prognostic Factors Related to Chemoradioresistance in Neoadjuvant Treatment of Locally Advanced Rectal Cancer at Panama","authors":"Daliana Jerez, Carla Luz, Jose Llerena, Rafael Arauz","doi":"10.11648/j.crj.20241202.11","DOIUrl":"https://doi.org/10.11648/j.crj.20241202.11","url":null,"abstract":"<i>Background:</i> In Panama, and the rest of Latin America, there are few publications on chemoradioresistance, it leads to poor prognosis and represents the main reason for failure of therapy, ultimately it can lead to tumor recurrence and metastasis. <i>Objective:</i> Identify factors associated with chemoradioresistance in the neoadjuvant treatment of locally advanced rectal cancer at the Instituto Oncológico Nacional de Panamá, period 2016-2020. Methodology: This retrospective study included 71 patients with LARC who received neoadjuvant chemoradiotherapy and surgery. Chemoradioresistant patients were those who did not reach a higher pathological stage of ypT2NO and the results were compared. <i>Results:</i> Of the 71 patients, pathological complete response (pCR) was achieved in 34 patients (48%). 49% of patients met chemoradioresistance criteria. In this group, the median CEA was 136 ng/ml, the median hemoglobin was 12 g/dl, and the median BMI was 26 kg/m2. The median radiation dose was 5000Gy. The time between completion of chemoradiotherapy and surgery was 110 days (16 weeks). Depending on the type of surgery, 65% who underwent low anterior resection were chemoradioresistant. The variables with statistical significance were the CEA value >5 ng/mL (OR=1.81, p=0.026) prior to the start of neoadjuvant treatment, with a lower pCR rate. Likewise, the ECOG scale (OR=2.51, p=0.015) was a risk factor related to chemoradioresistance, the lower the ECOG, the lower the risk of chemoradioresistance. The median overall survival and median recurrence-free survival was not reached in both groups and there was no statistically significant difference. <i>Conclusions:</i> Significant interactions were identified between CEA levels prior to the start of neoadjuvant treatment with the pathological complete response rate and the ECOG score with chemoradioresistance. Therefore, these factors can be used to predict patient outcomes, will help optimize personalized treatment strategies and improve patient outcomes.","PeriodicalId":503171,"journal":{"name":"Cancer Research Journal","volume":"76 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digestive Tract Cancers: Epidemiological, Anatomical and Clinical Aspects and Management at Conakry Hospital","authors":"Diakite Sandaly, Camara Fode Lansana, Diakité Saikou Yaya, Fofana Naby, Kondano Saa Yawo, Condé Ansoumane, C. Mariame, Condé Ousmane, Cisse Aly, T. Aboubacar","doi":"10.11648/j.crj.20241201.14","DOIUrl":"https://doi.org/10.11648/j.crj.20241201.14","url":null,"abstract":"Introduction: Digestive cancers represent between 10 and 50% of all cancers and therefore occupy a preponderant place in digestive surgery departments. Our general objective was to study the epidemiological, anatomo-clinical and therapeutic aspects of cancers of the digestive tract at the Conakry University Hospital. Methodology: This was a retrospective descriptive study covering a period of 6 years, from January 1, 2014 to December 31, 2019. Result: the hospital prevalence of cancers of the digestive tract was 6.34% with a male predominance of 54% and a sex ratio of 1.17. The average age was 52.7 years with the extremes of 13 and 84 years and 57% resided in Conakry. Alcohol and tobacco are the most popular stimulants. The most frequent reasons for consultations were epigastralgia 64.31%, vomiting / nausea 44.11%, Stomach and colon cancers were the most represented, i.e. 40.07% and 30.30% respectively. The treatment was curative (surgery) in 85.19% of cases and the outcome was favorable in almost three quarters of cases, or 71.04% of cases. We have 71 registered death cases. Conclusion: Cancers of the digestive tract remain non-negligible in our country and that of the stomach is the most common. The hope lies in equipping structures with proximity and adequate infrastructure for diagnosis and with consequent therapeutic means (radiotherapy), as well as raising awareness of early diagnosis within the community.\u0000","PeriodicalId":503171,"journal":{"name":"Cancer Research Journal","volume":"110 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesonephric-Like Adenocarcinoma of the Endometrium Mimicking Advanced Tubo-Ovarian Cancer - A Literature Review Based on a Special Case","authors":"Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Irene Krücken, Anne Hagert-Winkler, Mireille Martin, Adrian Pilny, Helmut Plett, C. Brambs, Lars-Christian Horn","doi":"10.11648/j.crj.20231104.12","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.12","url":null,"abstract":"","PeriodicalId":503171,"journal":{"name":"Cancer Research Journal","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139262875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Histopathological Profile of Prostate Cancer in Conakry","authors":"D. Oury, Bah Mamadou Bissiriou, Cissé Demba, Agossou Ahouéfa Diodirine, Bah Mamadou Diawo, Diallo Alimou, Diallo Thierno Oumar, Keita Youssouf, Kolié Aimé, D. A. Bobo, Bah Oumar Raphiou","doi":"10.11648/j.crj.20231104.11","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.11","url":null,"abstract":"","PeriodicalId":503171,"journal":{"name":"Cancer Research Journal","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139280122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidermoid Carcinoma of the Breast: Report of an Observation and Review of the Literature","authors":"Bangoura Mohamed Saliou, Diallo Mamadou Saliou, Soumah Mohamed Salifou, Youla Alpha Mohamed, Cisse Fode, Diallo Alseny, Camara Naby Laye Youssouf, Keita Abdoulaye, Yattara Abdoulaye, Soumaoro Labilé Togba, T. Aboubacar","doi":"10.11648/j.crj.20231102.16","DOIUrl":"https://doi.org/10.11648/j.crj.20231102.16","url":null,"abstract":"","PeriodicalId":503171,"journal":{"name":"Cancer Research Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Angiotensin II on the Malignant Biological Behaviors of Colorectal Cancer Cells and Its Mechanism of Action","authors":"Yingxue Yang, Xiaotian Yang, Qinghua Wang","doi":"10.11648/j.crj.20231102.17","DOIUrl":"https://doi.org/10.11648/j.crj.20231102.17","url":null,"abstract":"","PeriodicalId":503171,"journal":{"name":"Cancer Research Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}