Pulse最新文献

{"title":"The responses of arterial stiffness parameter Beta-derived index of\u0000the aorta and illiac-femoral artery to acute hypovolemia in rabbits","authors":"Toshiro Ito, S. Katsuda, Yuko Horikoshi, Toru Funyu, Akihiro Hazama, Tsuyoshi Shimizu, K. Shirai","doi":"10.1159/000539480","DOIUrl":"https://doi.org/10.1159/000539480","url":null,"abstract":"Introduction: Acute hemorrhage decreases blood pressure (BP) and sometimes causes hypovolemic shock. At this time, peripheral arteries are supposed to contract and increase peripheral vascular resistance to raise BP. However, there have not been an adequate index of a degree of arterial stiffness. We assessed changes in arterial stiffness during rapid bleeding using new BP-independent vascular indices, aBeta and ifBeta, determined by applying the cardio-ankle vascular index (CAVI) theory to the elastic (aorta) and muscular (common iliac-femoral) arteries, respectively in rabbits. Methods: Eleven Japanese white male rabbits were fixed at supine under pentobarbital anesthesia. Fifteen percent of the total blood volume was depleted at a rate of 2 mL/kg/min for 6 min; 15 min later, the withdrawn blood was re-transfused at the same rate. Pressure waves at the origin of the aorta (oA), distal end of the abdominal aorta, distal end of the left common iliac artery, and flow waves at oA were measured simultaneously. Beta was calculated using the following formula: Beta=2ρ/PP×ln(SBP/DBP)×PWV2, where ρ, SBP, DBP, and PP are blood density, and systolic, diastolic, and pulse pressures, respectively. aBeta, ifBeta and aortic-iliac-femoral Beta (aifBeta) were calculated using aPWV, ifPWV and aifPWV, respectively. Results: aBeta and aifBeta increased, while ifBeta decreased significantly during the decreased BP induced by the bleeding. Reverse reactions of those indices were observed by transfusing the removed blood. Conclusion: total arterial stiffness (aifBeta) increased, however, the elastic and muscular arteries stiffened and softened during the bleeding, respectively. These results would give useful diagnostic information during fall in BP.","PeriodicalId":502816,"journal":{"name":"Pulse","volume":"55 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular function and exercise training: Functional implication of nitric oxide signaling and ion channels","authors":"Junyoung Hong, Y. Park","doi":"10.1159/000538271","DOIUrl":"https://doi.org/10.1159/000538271","url":null,"abstract":"Exercise training elicits indubitable positive adaptation in microcirculation in health and disease populations. The main physiological function of microvasculature is to maintain optimal blood flow regulation to supply oxygen and nutrition during elevated physical demands in the cardiovascular system. There are several cellular and molecular alterations in resistance vessels in response to exercise intervention, an increase in nitric oxide-mediated vasodilation through the regulation of oxidative stress, inflammatory response, and ion channels in endothelial cells, thus increasing myogenic tone via voltage-gated Ca2+ channels in smooth muscle cells. Here in the review, we postulate that exercise should be considered a medicine for people with diverse diseases through a comprehensive understanding of the cellular and molecular underlying mechanisms in microcirculation by exercise training.","PeriodicalId":502816,"journal":{"name":"Pulse","volume":"273 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140249393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue outbreak 2023: Awareness can lower the burden of dengue infection and mortality","authors":"Arif Mahmud","doi":"10.3329/pulse.v15i1.70902","DOIUrl":"https://doi.org/10.3329/pulse.v15i1.70902","url":null,"abstract":"Abstract not available \u0000Pulse Vol.15, 2023 P: 3-4","PeriodicalId":502816,"journal":{"name":"Pulse","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139621575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Immunohistochemistry in the Subtyping of Lung Carcinoma on Small Biopsies","authors":"S. M. Mahbubul, Ahmed Khaled, Saiful Islam, Taohida Yasmin, Narita Khurshid, Dr. S M Mahbubul Alam","doi":"10.3329/pulse.v15i1.70905","DOIUrl":"https://doi.org/10.3329/pulse.v15i1.70905","url":null,"abstract":"Background: Hamstring tendon auto grafts in the form of quadrupled Background and objectives: In the era of precision medicine, the important task of today’s pathologist is to classify lung carcinoma into specific histologic subtypes. Thus enables the scope to identify the molecular target for targeted therapy. Hematoxylin and eosin stain alone cannot subtype lung carcinoma when particularly it exhibits solid pattern of growth. This challenge becomes more pronounced when working with small biopsy samples.\u0000Methodology and result: A retrospective cross-sectional study was conducted to evaluate small biopsies obtained by image guided lung core or bronchoscopy over three years, from 2020-2022. Tumour morphology was evaluated, and immunohistochemistry was performed in 132 cases of lung carcinoma. In this study a small panel of three markers (TTF-1, p63 and synaptophysin) was applied as an initial approach to classify different subtypes of lung carcinoma. Additional markers (such as NapsinA, p40, CK5/6, CD56, INSM1, CK7, CK20, etc.) were incorporated based on factors like morphological characteristics, clinical information, imaging data, and the results of the initial marker panel. The largest group observed in this study comprised 67% of adenocarcinomas that showed positivity for either TTF-1 or NapsinA. Squamous cell carcinomas, identified either through p63 expression or other markers such as p40/CK5/6, accounted for 26% of cases. Additionally, 10% of cases demonstrated reactivity to neuroendocrine markers, indicating the presence of neuroendocrine tumors. Notably, immunohistochemistry successfully identified the metastatic site for 10 adenocarcinomas that were negative for both TTF-1 and NapsinA.\u0000Conclusion: A small panel of immunomarkers can classify the lung cancer reliably and increases the confidence at all level of lung cancer management.\u0000Pulse Vol.15, 2023 P: 16-21","PeriodicalId":502816,"journal":{"name":"Pulse","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139621688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CME of Evercare Hospital Dhaka - 2023 (Jan - Nov)","authors":"Raihan Hussain","doi":"10.3329/pulse.v15i1.70921","DOIUrl":"https://doi.org/10.3329/pulse.v15i1.70921","url":null,"abstract":"Abstract not available \u0000Pulse Vol.15, 2023 P: 54-55","PeriodicalId":502816,"journal":{"name":"Pulse","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139620908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Ureaplasma Species in Urogenital Samples by Real-Time PCR in Suspected Sexually Transmitted Infection Patients Attended in Evercare Hospital Dhaka in 2022","authors":"Nazmul Hasan, R. Rahim, A. Hasan, Mizanur Rahman","doi":"10.3329/pulse.v15i1.70913","DOIUrl":"https://doi.org/10.3329/pulse.v15i1.70913","url":null,"abstract":"Background: Sexually Transmitted Infections (STIs) are a continual and under-diagnosed disease. Mycoplasma hominis (M. hominis), Ureaplasma urealyticum (U. urealyticum), Ureaplasma parvum (U. parvum) are potential pathogens for urogenital infection of males and females. However, the association of these pathogens with STIs in our country is not yet reported. To determine the existence of M. hominis, U. urealyticum, U. parvum urogenital samples from suspected STIs patients who attended Evercare Hospital Dhaka were investigated. \u0000Materials and methods: Extracted DNA from urine, prostatic secretion, urethral swab, and high vaginal swab as per clinician’s recommendation from 50 cases already tested negative for Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis were used in this study from February 2022 to August 2022. Extracted and stored DNA were screened by multiplex real-time PCR for M. hominis, U. urealyticum, U. parvum. \u0000Result: Ureaplasma was detected in 12 (24%) samples, U. parvum in 9 (75%), and U. urealyticum in 3 (25%) samples. No pathogens were isolated by routine culture from any of these samples. The positivity rate was more frequent in males (66.6%) than females (33.4%) and in the age group between 19-40 years old. \u0000Conclusion: Our data show a significant association of Ureaplasma in STIs patients who attended this hospital. Large scale study is recommended for exploring the prevalence in the community and the role of this pathogen in STIs. \u0000Pulse Vol.15, 2023 P: 5-8","PeriodicalId":502816,"journal":{"name":"Pulse","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139620706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ongoing Challenges of Extubation of COVID-Pneumonic Patient in Multi-Organ Failure: a Case Report","authors":"Dr. Md Zulfiker Riad, Ibn Aziz, Q. M. Ullah, Jasmin Manzoor, Rubaiya Ali, Walid Hasan Khan, Senior Consultant, Coordinator, Dr. Q. M. Mahbub, Ullah Sr. consultant","doi":"10.3329/pulse.v15i1.70928","DOIUrl":"https://doi.org/10.3329/pulse.v15i1.70928","url":null,"abstract":"In this report, a case of a patient with COVID-19 pneumonia is presented who developed multi-organ failure and required mechanical ventilation. Despite multiple attempts at extubation, the patient remained intubated for an extended period due to respiratory failure. The challenges encountered during the process of extubation are discussed and the strategies employed to overcome them. This case highlights the importance of careful decision and management in patients with COVID-19 pneumonia for extubation who develop multi-organ failure. \u0000Pulse Vol.15, 2023 P: 45-50","PeriodicalId":502816,"journal":{"name":"Pulse","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Long-term Outcome of Arthroscopic Reconstruction of Anterior Cruciate Ligament Injury by Hamstring quadrupled Auto graft fixed by Bio Screws in a tertiary level hospital","authors":"Md Muztaba Ali, Md. Tanvir Rahman, Nazmee Kabir, Tamzid Billah, Tamam Rahman, Shihat Ahmed, Md. Sohel","doi":"10.3329/pulse.v15i1.70904","DOIUrl":"https://doi.org/10.3329/pulse.v15i1.70904","url":null,"abstract":"Background: Hamstring tendon auto grafts in the form of quadrupled semitendinosus and gracilis (STG) has become an increasingly used alternative for anterior cruciate ligament (ACL) reconstruction. Bio screw avoids complications by decreasing possibility of graft damage. Current study was designed to evaluate arthroscopic ACL reconstruction with quadrupled semitendinosus auto graft and fixation of the graft by two biodegradable screws in both femur and tibia. \u0000Objectives: This study was conducted to evaluate the outcome of arthroscopic ACL reconstruction by semitendinosus tendon autograft using biodegradable screws for both tibia and femur. Methods: 300 patients with ACL injury admitted from January 2010 to December 2015 in the then Apollo Hospitals Dhaka (Evercare Hospital Dhaka now) were enrolled. All patients underwent ACL reconstruction surgery by quadrupled semitendinosus or gracilis auto graft fixed by Bio Screws. After discharge, these patients were followed up for 3 weeks, 3 months and final outcome was recorded after 6 years. \u0000Results: 270 patients (90%) had an uneventful post-operative period. 200 patients (66.67%) complained of postoperative pain after 3 weeks, 10 patients (3.33%) complained of knee swelling, 10 (3.33%) patients had infections & 20 patients (6.65%) had knee stiffness after 6 months. Postoperatively, Lachman test improved significantly, grade 0 in 93.33% cases (280 patients) and grade I was in 6.67% cases (20 patients). Anterior drawer test was also markedly improved. Grade 0 was in 93.33% cases (280 patients) and grade I was in 6.67% cases (20 patients). According to the Lysholm Knee Scoring, the final long-term outcome was excellent in 76.67% cases (230 patients), good in 20% cases (60 patients) and fair in 3.33% cases (10 patients). \u0000Conclusion: Arthroscopic reconstruction of ACL by quadrupled hamstring autograft fixed by biodegradable screws for both tibia and femur, leads good to excellent results in the majority of the cases. \u0000Pulse Vol.15, 2023 P: 9-15","PeriodicalId":502816,"journal":{"name":"Pulse","volume":" 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139621318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}