Artur K. Schuster, Nevra K. Yilmaz, Tomotaka Shimura, Sebahattin Cureoglu, Rafael da Costa Monsanto, Joel Lavinsky
{"title":"Comparative Histopathologic Analysis of Inner Ear Damage in Meningitis: Otogenic Versus Meningogenic Routes","authors":"Artur K. Schuster, Nevra K. Yilmaz, Tomotaka Shimura, Sebahattin Cureoglu, Rafael da Costa Monsanto, Joel Lavinsky","doi":"10.1002/lary.31759","DOIUrl":"https://doi.org/10.1002/lary.31759","url":null,"abstract":"ObjectiveTo distinguish the patterns of inner ear changes between meningogenic and otogenic routes in meningitis cases. Our hypothesis is that pinpointing distinct patterns linked to each route could aid in the development of diagnostic strategies and targeted therapies.MethodsTemporal bones (TBs) from patients with a history of meningitis and histopathological evidence of labyrinthitis were divided into two groups (otogenic and meningogenic). Inner ear histopathological examination was performed to identify qualitative and semi‐quantitative changes. This assessment encompassed inflammation patterns, indications of early ossification, hair cell loss, and alterations in the lateral wall, round window membrane, cochlear aqueduct and vestibular aqueduct.ResultsThirty‐six TBs were included in the study (otogenic, 21; meningogenic, 15). Generalized labyrinthitis was more common in otogenic cases (100% vs. 53%, <jats:italic>p</jats:italic> < 0.001). Early signs of cochlear ossification were exclusively observed in otogenic cases (9 TBs). The spiral ligament of otogenic cases has shown a uniform loss of fibrocytes across all cochlear turns, while meningogenic cases showed more severe loss in the apical turn. Otogenic cases exhibited a higher prevalence of severe inflammation of the cochlear aqueduct and endolymphatic sac. Meningogenic cases showed more severe loss of vestibular hair cells in the otolithic organs.ConclusionOtogenic cases displayed a higher prevalence of changes in the spiral ligament and signs of early ossification, whereas meningogenic cases were associated with a higher degree of vestibular damage. Our findings emphasize the importance of considering the infection route and its implications for timely diagnosis and development of pathology‐oriented treatment strategies.Level of EvidenceNA <jats:italic>Laryngoscope</jats:italic>, 2024","PeriodicalId":501696,"journal":{"name":"The Laryngoscope","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanner J. Diemer, Douglas P. Nanu, Shaun A. Nguyen, Badr Ibrahim, Ted A. Meyer, Mohamed Abdelwahab
{"title":"Maxillomandibular Advancement for Obstructive Sleep Apnea in Patients With Obesity: A Meta‐Analysis","authors":"Tanner J. Diemer, Douglas P. Nanu, Shaun A. Nguyen, Badr Ibrahim, Ted A. Meyer, Mohamed Abdelwahab","doi":"10.1002/lary.31751","DOIUrl":"https://doi.org/10.1002/lary.31751","url":null,"abstract":"ObjectiveTo systematically review polysomnographic and cephalometric data in obstructive sleep apnea (OSA) patients with obesity (body mass index [BMI] ≥30 kg/m<jats:sup>2</jats:sup>) treated with maxillomandibular advancement (MMA).Data SourcesScopus, PubMed, CINAHL, and The COCHRANE Library.Review MethodsA search was performed from inception until April 3, 2024, in each database.ResultsA total of 14 studies (143 subjects) were included. The mean age was 44.3 years (range: 17–69), 80.2% males (95% CI: 72.5–86.5), mean BMI of 35.3 (95% CI: 33.1–37.5), and mean duration to follow‐up post‐MMA was 13.7 months (95% CI: 10.1–17.3). All objective outcomes improved significantly; overall, apnea‐hypopnea index (AHI) decreased by −57.3 ([95% CI: −71.5 to −43.2], <jats:italic>p</jats:italic> < 0.0001) lowest oxygen saturation (LSAT) increased by 14.1% ([95% CI: 9.9 to 18.3], <jats:italic>p</jats:italic> < 0.0001), and Epworth Sleepiness Scale (ESS) decreased by −9.4 ([95% CI: −13.5 to −5.2], <jats:italic>p</jats:italic> < 0.0001). Surgical cure was 39.2% (95% CI: 20.3–60.0), and surgical success was 85.6% (95% CI: 77.8–91.5). Comparing percent reduction in class 3 obesity (−92.9%) as compared to class 1 (−85.5%) and class 2 (−83.6%) exhibited a significant difference (1 vs 3 <jats:italic>p</jats:italic> = 0.0012, 2 vs 3 <jats:italic>p</jats:italic> = 0.015).ConclusionsOur findings suggest that MMA significantly improves subjective and objective outcomes in OSA amongst patients with obesity with results comparable to the overall population. Success rates remained above 80% in studies with the highest mean BMI. In addition, patients with class 3 obesity yielded a significantly increased benefit based on percent reduction in AHI compared with class 1 and 2.Level of Evidence1 <jats:italic>Laryngoscope</jats:italic>, 2024","PeriodicalId":501696,"journal":{"name":"The Laryngoscope","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142191574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Liao, Mark Lee, Andre Shomorony, Rachel Weitzman, Anthony P. Sclafani
{"title":"Zoom Boom or Bust? Understanding Post‐Pandemic Interest in Facial Plastic Surgery via Google Trends","authors":"David Liao, Mark Lee, Andre Shomorony, Rachel Weitzman, Anthony P. Sclafani","doi":"10.1002/lary.31753","DOIUrl":"https://doi.org/10.1002/lary.31753","url":null,"abstract":"ObjectiveTo understand post‐pandemic interest in plastic surgery procedures via Joinpoint analysis of Google Trends search data.MethodsGoogle Trends was used to quantify search volumes from January 2019–December 2022 for select cosmetic face and body procedures in the United States. A keyword analytic tool (Keywords Everywhere) extracted absolute search volumes (average monthly searches). Joinpoint analysis assessed search trends over time reported as monthly percentage change (MPC).ResultsAll procedures queried, including a non‐cosmetic control (cataract surgery), demonstrated expected declines at the start of the COVID‐19 pandemic. Blepharoplasty, face lift, neck lift, and Botox demonstrated statistically significant increase in search volumes that remained elevated relative to pre‐pandemic levels. Rhinoplasty, fillers, and abdominoplasty interest increased initially followed by return to pre‐pandemic levels by the end of 2022. The remainder of search terms did not show a clear temporal associated with COVID‐19 lockdowns.ConclusionThe “Zoom Boom” appears to be a real phenomenon reflected by sustained increase in public interest in relation to facial plastic procedures.Level of EvidenceNA <jats:italic>Laryngoscope</jats:italic>, 2024","PeriodicalId":501696,"journal":{"name":"The Laryngoscope","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142191579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Zheng Jie Teng, Pei Yuan Fong, Issam Al Jajeh, Andy Jian Kai Chua
{"title":"Encysted Tubular Sweat Gland Adenoma of the Nasal Ala: A Rare Cause for Unilateral Nasal Discharge","authors":"Thomas Zheng Jie Teng, Pei Yuan Fong, Issam Al Jajeh, Andy Jian Kai Chua","doi":"10.1002/lary.31765","DOIUrl":"https://doi.org/10.1002/lary.31765","url":null,"abstract":"Benign cutaneous apocrine sweat gland adenomas in the nose are rare. We present the novel case of a nasal ala cutaneous sweat gland lesion. A 43‐year‐old male presents with a one year history of a right nostril mass with intermittent clear discharge, triggered by periods of hot weather and increased humidity. Histopathological analysis post‐excision revealed a solid‐cystic lesion of bi‐layered ducts, with snouts suggestive of apocrine secretions. Given the close relationship of tumour enlargement with heat and expression of clear liquid upon direct pressure, we postulate that the intermittent tumescence represents sweat production and accumulation within the lesion. <jats:italic>Laryngoscope</jats:italic>, 2024","PeriodicalId":501696,"journal":{"name":"The Laryngoscope","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142191576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Reference to When Should We Recommend Intracapsular Tonsillectomy in Pediatric Patients?","authors":"Jeffrey Koempel","doi":"10.1002/lary.31764","DOIUrl":"https://doi.org/10.1002/lary.31764","url":null,"abstract":"","PeriodicalId":501696,"journal":{"name":"The Laryngoscope","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142191578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahul Alapati, Bryan Renslo, Sarah F. Wagoner, Omar Karadaghy, Aisha Serpedin, Yeo Eun Kim, Maria Feucht, Naomi Wang, Uma Ramesh, Antonio Bon Nieves, Amelia Lawrence, Celina Virgen, Tuleen Sawaf, Anaïs Rameau, Andrés M. Bur
{"title":"Assessing the Reporting Quality of Machine Learning Algorithms in Head and Neck Oncology","authors":"Rahul Alapati, Bryan Renslo, Sarah F. Wagoner, Omar Karadaghy, Aisha Serpedin, Yeo Eun Kim, Maria Feucht, Naomi Wang, Uma Ramesh, Antonio Bon Nieves, Amelia Lawrence, Celina Virgen, Tuleen Sawaf, Anaïs Rameau, Andrés M. Bur","doi":"10.1002/lary.31756","DOIUrl":"https://doi.org/10.1002/lary.31756","url":null,"abstract":"ObjectiveThis study aimed to assess reporting quality of machine learning (ML) algorithms in the head and neck oncology literature using the TRIPOD‐AI criteria.Data SourcesA comprehensive search was conducted using PubMed, Scopus, Embase, and Cochrane Database of Systematic Reviews, incorporating search terms related to “artificial intelligence,” “machine learning,” “deep learning,” “neural network,” and various head and neck neoplasms.Review MethodsTwo independent reviewers analyzed each published study for adherence to the 65‐point TRIPOD‐AI criteria. Items were classified as “Yes,” “No,” or “NA” for each publication. The proportion of studies satisfying each TRIPOD‐AI criterion was calculated. Additionally, the evidence level for each study was evaluated independently by two reviewers using the Oxford Centre for Evidence‐Based Medicine (OCEBM) Levels of Evidence. Discrepancies were reconciled through discussion until consensus was reached.ResultsThe study highlights the need for improvements in ML algorithm reporting in head and neck oncology. This includes more comprehensive descriptions of datasets, standardization of model performance reporting, and increased sharing of ML models, data, and code with the research community. Adoption of TRIPOD‐AI is necessary for achieving standardized ML research reporting in head and neck oncology.ConclusionCurrent reporting of ML algorithms hinders clinical application, reproducibility, and understanding of the data used for model training. To overcome these limitations and improve patient and clinician trust, ML developers should provide open access to models, code, and source data, fostering iterative progress through community critique, thus enhancing model accuracy and mitigating biases.Level of EvidenceNA <jats:italic>Laryngoscope</jats:italic>, 2024","PeriodicalId":501696,"journal":{"name":"The Laryngoscope","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142191606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}