Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease最新文献

{"title":"Spermidine ameliorates osteoarthritis via altering macrophage polarization","authors":"Q. Ou, Su'an Tang, Jianwei Zhu, Song Xue, Hong Huang, Yang Zhao, Yu Cai, Cuixi Wu, Jianmao Chen, G. Ruan, Changhai Ding","doi":"10.1016/j.bbadis.2024.167083","DOIUrl":"https://doi.org/10.1016/j.bbadis.2024.167083","url":null,"abstract":"","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139829563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-κB signaling pathway","authors":"Hongdou Jin, Zhirong Huan, Yifeng Wu, Hao Yao, Leyao Zhang, Xin Ge","doi":"10.1016/j.bbadis.2024.167082","DOIUrl":"https://doi.org/10.1016/j.bbadis.2024.167082","url":null,"abstract":"","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"House dust mite allergens induce Ca2+ signalling and alarmin responses in asthma airway epithelial cells","authors":"Ouyang Xuan, J. Reihill, Lisa E.J. Douglas, Orla M. Dunne, Gerard P. Sergeant, S. L. Martin","doi":"10.1016/j.bbadis.2024.167079","DOIUrl":"https://doi.org/10.1016/j.bbadis.2024.167079","url":null,"abstract":"","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration","authors":"Maria João Nunes, Andreia Neves Carvalho, Joana Reis, Daniela Costa, Miguel Moutinho, Joana Mateus, Rita Mendes de Almeida, Sara Brito, Daniela Risso, Sofia Nunes, Margarida Castro-Caldas, Maria João Gama, Cecília M.P. Rodrigues, Sara Xapelli, Maria José Diógenes, Nathalie Cartier, Farah Chali, Françoise Piguet, Elsa Rodrigues","doi":"10.1016/j.bbadis.2023.166993","DOIUrl":"https://doi.org/10.1016/j.bbadis.2023.166993","url":null,"abstract":"<p>Cholesterol 24-hydroxylase (CYP46A1) is an exclusively neuronal cytochrome P450 enzyme responsible for converting cholesterol into 24S-hydroxycholesterol, which serves as the primary pathway for eliminating cholesterol in the brain. We and others have shown that increased activity of CYP46A1 leads to reduced levels of cholesterol and has a positive effect on cognition. Therefore, we hypothesized that CYP46A1 could be a potential therapeutic target in Niemann-Pick type C (NPC) disease, a rare and fatal neurodegenerative disorder, characterized by cholesterol accumulation in endolysosomal compartments. Herein, we show that CYP46A1 ectopic expression, in cellular models of NPC and in Npc1^tm(I1061T) mice by adeno-associated virus-mediated gene therapy improved NPC disease phenotype. Amelioration in functional, biochemical, molecular and neuropathological hallmarks of NPC disease were characterized. <em>In vivo</em>, CYP46A1 expression partially prevented weight loss and hepatomegaly, corrected the expression levels of genes involved in cholesterol homeostasis, and promoted a redistribution of brain cholesterol accumulated in late endosomes/lysosomes. Moreover, concomitant with the amelioration of cholesterol metabolism dysregulation, CYP46A1 attenuated microgliosis and lysosomal dysfunction in mouse cerebellum, favoring a pro-resolving phenotype. <em>In vivo</em> CYP46A1 ectopic expression improves important features of NPC disease and may represent a valid therapeutic approach to be used concomitantly with other drugs. However, promoting cholesterol redistribution does not appear to be enough to prevent Purkinje neuronal death in the cerebellum. This indicates that cholesterol buildup in neurons might not be the main cause of neurodegeneration in this human lipidosis.</p>","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose transport, transporters and metabolism in diabetic retinopathy","authors":"Chaoyang Zhang, Limin Gu, Hai Xie, Yan Liu, Peirong Huang, Jingting Zhang, Dawei Luo, Jingfa Zhang","doi":"10.1016/j.bbadis.2023.166995","DOIUrl":"https://doi.org/10.1016/j.bbadis.2023.166995","url":null,"abstract":"<p>Diabetic retinopathy (DR) is the most common reason for blindness in working-age individuals globally. Prolonged high blood glucose is a main causative factor for DR development, and glucose transport is prerequisite for the above disturbances in DR caused by hyperglycemia. Glucose transport is mediated by its transporters, including the facilitated transporters (glucose transporter, GLUTs), the “active” glucose transporters (sodium-dependent glucose transporters, SGLTs), and the SLC50 family of uniporters (sugars will eventually be exported transporters, SWEETs). Glucose transport across the blood-retinal barrier (BRB) is crucial for nourishing the neuronal retina in the context of retinal physiology. This physiological process primarily relies on GLUTs and SGLTs, which mediate the glucose transportation across both the cell membrane of retinal capillary endothelial cells and the retinal pigment epithelium (RPE). Under diabetic conditions, increased accumulation of extracellular glucose enhances the retinal cellular glucose uptake and metabolism via both glycolysis and glycolytic side branches, which activates several biochemical pathways, including the protein kinase C, advanced glycation end-products (AGEs), polyol pathway and hexosamine biosynthetic pathway (HBP). These activated biochemical pathways further increase the production of reactive oxygen species (ROS), leading to oxidative stress and activation of Poly (ADP-ribose) polymerase (PARP). The activated PARP further affects all the cellular components in the retina, and finally resulting in microangiopathy, neurodegeneration and low-to-moderate grade inflammation in DR. This review aims to discuss the changes of glucose transport, glucose transporters, as well as its metabolism in DR, which influences the retinal neurovascular unit and implies the possible therapeutic strategies for treating DR.</p>","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma","authors":"Shuai He, Ming Lu, Liang Zhang, Zhe Wang","doi":"10.1016/j.bbadis.2023.166996","DOIUrl":"https://doi.org/10.1016/j.bbadis.2023.166996","url":null,"abstract":"<p>High infiltration of tumor-associated macrophages (TAMs) participates in host immunity and tumor progression in patients with esophageal squamous cell carcinoma (ESCC). Ribosomal s6 kinase 4 (RSK4) has been shown to be aberrantly overexpressed in ESCC. The role of RSK4 in cytokine secretion and its impact on macrophage recruitment and polarization remains unclear. Therefore, a thorough understanding of RSK4 is needed to expand our knowledge of its therapeutic potential. Herein, RSK4 expression in human ESCC tissues and a xenograft mouse model was positively correlated with high infiltration of M0 and M2 macrophages which is positively associated with unfavorable overall survival outcomes and treatment resistance in patients with ESCC. <em>In vitro</em> experiments revealed that RSK4 derived from ESCC cells promoted macrophage recruitment and M2 polarization by enhancing sICAM-1 secretion <em>via</em> direct and indirect STAT3 phosphorylation. Furthermore, RSK4-induced macrophages enhanced tumor proliferation, migration, and invasion by secreting CCL22. We further showed that patients with elevated CD68 and CD206 expression had unfavorable overall survival. Collectively, these results demonstrate that RSK4 promotes the macrophage recruitment and M2 polarization by regulating the STAT3/ICAM-1 axis in ESCC, influencing tumor progression primarily in a CCL22-dependent manner. These data also offer valuable insights for developing novel agents for the treatment of ESCC.</p>","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionizing radiation induces vascular smooth muscle cell senescence through activating NF-κB/CTCF/p16 pathway","authors":"Xuefeng Zheng, Zhiwei Liu, Yawen Bin, Jiaojiao Wang, Xinrui Rao, Gang Wu, Xiaorong Dong, Fan Tong","doi":"10.1016/j.bbadis.2023.166994","DOIUrl":"https://doi.org/10.1016/j.bbadis.2023.166994","url":null,"abstract":"<p>Radiation injury of blood vessels (RIBV) is a serious long-term complication of radiotherapy, characterized by the development of atherosclerosis. The involvement of vascular smooth muscle cells (VSMCs) senescence in the pathogenesis of radiation-induced atherosclerosis has been implicated, yet the precise mechanisms governing VSMCs senescence remain inadequately comprehended. In this study, the senescence of VSMCs was examined by employing SA-β-gal staining and assessing the expression of p16 and p21, both in vivo <em>and</em> in vitro. Our findings revealed that ionizing radiation (IR) has the potential to augment cellular senescence. In addition, IR significantly activated the NF-κB pathway, as evidenced by increased p65 nuclear translocation, phospho-p65 expression, and enhanced binding ability of p65 (EMSA). Furthermore, a decrease in HMGB2 expression following exposure to IR was observed via Western blot analysis, while CTCF expression remained unchanged. Interestingly, the formation of CTCF spatial clustering was detected under super-resolution fluorescence microscopy. Concurrently, the ChIP technique identified the facilitation of the interaction between CTCF and p16 gene through IR. The inhibition of CTCF or the overexpression of HMGB2 through lentiviruses effectively eliminates the formation of CTCF clusters and the upregulation of p16 and p21 after IR. Inhibition of NF-κB activation induced by IR by PDTC (100 μM) led to a decrease in the staining of SA-β-gal, a reduction in p16 expression, an increase in HMGB2 protein expression and a decrease in CTCF clusters formation. This study provided significant insights into the role and mechanism of IR in VSMCs senescence by regulating NF-κB/CTCF/p16 pathway.</p>","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STING activation in cardiomyocytes drives hypertrophy-associated heart failure via NF-κB-mediated inflammatory response","authors":"Lintao Wang, Suya Zhang, Hongxia Liu, Li Gao, Lu He, Yue Chen, Junsheng Zhang, Miaomiao Yang, Chaoyong He","doi":"10.1016/j.bbadis.2023.166997","DOIUrl":"https://doi.org/10.1016/j.bbadis.2023.166997","url":null,"abstract":"","PeriodicalId":501217,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}