Open access journal of dental sciences最新文献

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3D Oral Mucosal Models for Studying Host-Pathogen Interactions in Periodontal Disease 三维口腔黏膜模型用于研究牙周病中宿主-病原体相互作用

Open access journal of dental sciences Pub Date : 2023-01-01 DOI: 10.23880/oajds-16000378

Lu Emily Ming-Chieh

{"title":"3D Oral Mucosal Models for Studying Host-Pathogen Interactions in Periodontal Disease","authors":"Lu Emily Ming-Chieh","doi":"10.23880/oajds-16000378","DOIUrl":"https://doi.org/10.23880/oajds-16000378","url":null,"abstract":"The host immune response to the oral biofilm plays a central role in the aetiology of periodontitis. Our understanding of hostpathogen interactions has historically been reliant on monolayer culture systems stimulated by microorganisms. However, 2D culture systems possess major shortcomings as these do not adequately mimic the complexities of the native tissue and therefore fail to provide meaningful information on the pathogenesis of periodontal disease. To mimic the in vivo condition, various types of 3D oral mucosal equivalents (OME) have been employed, including reconstituted models and 3D organotypic culture models. The rationale for OME is to serve as a relevant in vitro tool to examine the interactions of human epithelial cells with bacterial biofilms, to understand the process of epithelial layer damage, molecular mechanisms underpinning the development of periodontitis and models for testing novel therapeutics. Furthermore, to gain a deeper understanding of periodontal dysbiosis, it is important to appreciate the molecular mechanisms underlying host epithelial cell production of cytokines and chemokines in response to bacterial stimulation; and signalling pathways which underpin host-pathogen interactions such as mitogen-activated protein kinases (MAPK) and nuclear factor kappa light chain enhancer of activated B cells (NFkB). Thus, the aim of this narrative review is to summarise the evidence regarding the application of 3D oral mucosal models in host-pathogen infection studies relating to periodontal disease, review the molecular mechanisms underlying host response and provide recommendations for future studies in this field.","PeriodicalId":500728,"journal":{"name":"Open access journal of dental sciences","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135316643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potency of Acid Content in Local and Imported Strawberry Fruit Extract (Fragaria X Ananassa) as Natural Ingredients for Teeth Whitening 本地和进口草莓果提取物(Fragaria X Ananassa)作为牙齿美白天然成分的酸含量效价

Open access journal of dental sciences Pub Date : 2023-01-01 DOI: 10.23880/oajds-16000377

Sari Dewiyani

{"title":"Potency of Acid Content in Local and Imported Strawberry Fruit Extract (Fragaria X Ananassa) as Natural Ingredients for Teeth Whitening","authors":"Sari Dewiyani","doi":"10.23880/oajds-16000377","DOIUrl":"https://doi.org/10.23880/oajds-16000377","url":null,"abstract":"Background: Bleaching treatment is a whitening treatment for discolored teeth to restore their aesthetic function. The bleaching agent that is commonly used is 35% carbamide peroxide. Strawberries contain malic acid which can whiten teeth. Purpose: This study aims to find out acid potential on strawberries as a natural ingredient for teeth whitening. Methods: 48 post-extraction permanent single-rooted teeth that had been coated with clear nail polish were soaked in black coffee for 2 days, then 16 teeth were immersed in a local strawberry extract solution, 16 teeth were immersed in an imported strawberry extract solution and the other 16 teeth were immersed in a 35% carbamide peroxide gel solution and then observed and measured the color of the teeth after immersion at 24 hours and 48 hours. Results: There is potential for local and imported strawberry fruit extract in whitening teeth but the whitening potential when compared to carbamide peroxide is not significant (p>0.05). The whitening potential of imported strawberry juice is higher than that of local strawberry juice based on the average value. Conclusion: Based on research results, local and imported strawberry juice extracts have the potential to whiten discolored teeth.","PeriodicalId":500728,"journal":{"name":"Open access journal of dental sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Periodontal Disease, Etiology, Pathogenesis, Diagnosis and Treatment Therapy 牙周病概述，病因，发病机制，诊断和治疗

Open access journal of dental sciences Pub Date : 2023-01-01 DOI: 10.23880/oajds-16000376

Shaymaa Hussein Rafat Kotb

{"title":"Overview of Periodontal Disease, Etiology, Pathogenesis, Diagnosis and Treatment Therapy","authors":"Shaymaa Hussein Rafat Kotb","doi":"10.23880/oajds-16000376","DOIUrl":"https://doi.org/10.23880/oajds-16000376","url":null,"abstract":"Periodontal Disease is the most common chronic inflammatory bacterial disease that dramatically affects tooth loss and consequent adverse effects not only on the patient's aesthetics and self-confidence but also on the general condition of the body. Because of the high expectation of aggressive behaviour of periodontal disease, the ability to diagnosis and treat early may decrease the risk of tooth loss. So a complete understanding of its silent characteristic is the key. Aim: to thoroughly light on the significance of the early diagnosis and treatment of periodontal diseases which will take part in good prognosis and better outcomes on oral and general health. Methodology: A systematic literature review depends on collecting data from an evidence based studies. Searches were made of twenty electronic databases: the Cochrane Oral Health Group’s Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PsycINFO, Scopus and Web of science, MEDLINE (PubMed). Results: There is a statistically significant clinical improvement in all clinical parameter and biochemical analysis following the periodontal therapy treatment which effect on tooth shelf life. Conclusion: The results proved the benefit of periodontal therapy as a promising treatment therapy in improving periodontal parameters. Understanding the etiology of the progression of periodontal diseases is a very essential step to stopping the disease.","PeriodicalId":500728,"journal":{"name":"Open access journal of dental sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0