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Design and Optimization of Elanzapine Drug Release with Polyoxazoline Based Hydrogel 聚恶唑啉基水凝胶释放依氮平的设计与优化

Journal of Chemistry Studies Pub Date : 2023-10-14 DOI: 10.32996/jcs.2023.2.2.1

Zabiulllah Zalmay, Ruhullah Hanif, Shirullah Rahmani, Sayad Amiry, Wahidullah Enayat

{"title":"Design and Optimization of Elanzapine Drug Release with Polyoxazoline Based Hydrogel","authors":"Zabiulllah Zalmay, Ruhullah Hanif, Shirullah Rahmani, Sayad Amiry, Wahidullah Enayat","doi":"10.32996/jcs.2023.2.2.1","DOIUrl":"https://doi.org/10.32996/jcs.2023.2.2.1","url":null,"abstract":"Due to the fact that Elanzapine is prescribed orally and by injection for psychotic and schizophrenic disorders, and depending on the type of disease, these people are prevented from swallowing the drug; therefore, checking the injectable form of the drug with controlled release, which increases the release of the drug to one week with a single injection, is important. On the other hand, one of the most important biodegradable polymers that have the adhesive property of Elanzapine is Polyoxazoline, so the aim of this study is to design a slow release system, considering the short half-life of this drug and the need for a large number of doses and the patient's lack of cooperation for treatment. The drug is based on Polyoxazoline, which can reduce the consumption and, consequently, the toxicity and accumulation of the drug in the body. Mathematical heart direction, the forecast of different conditions will be presented, and also obtaining the optimal conditions and the final formulation is one of the main goals of this study. In this research, the release of olanzapine on the matrix loaded with olanzapine, the morphological characteristics of the matrix, the thermal characteristics of the matrix and the rheological characteristics of the matrix have been investigated. The release of olanzapine in the examined gels lasted for more than 168 hours, which was a sign of the slow release system, which is the main goal of this project. Several models were used to investigate the release kinetics of olanzapine, and among them, the Higuchi equation showed the best degree of regression with experimental data. By increasing the percentage of Elanzapine, the process of changes in viscosity goes out of the linear state; on the other hand, the difference between the optimum matrix viscosity of 3 and 4% of Elanzapine is small.","PeriodicalId":500191,"journal":{"name":"Journal of Chemistry Studies","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey of the Achievement of a ZnO Dye-Synthesized Solar Cell ZnO染料合成太阳能电池的研究进展

Journal of Chemistry Studies Pub Date : 2023-01-01 DOI: 10.32996/jcs.2022.2.1.1

Salisu Ishiyaku kunya, Yunusa Abdu, Mohd Kamarulzaki Mustafa, Mohd Khairul Ahmad

{"title":"Survey of the Achievement of a ZnO Dye-Synthesized Solar Cell","authors":"Salisu Ishiyaku kunya, Yunusa Abdu, Mohd Kamarulzaki Mustafa, Mohd Khairul Ahmad","doi":"10.32996/jcs.2022.2.1.1","DOIUrl":"https://doi.org/10.32996/jcs.2022.2.1.1","url":null,"abstract":"The adoption of renewable energy resources is already becoming incredibly valuable if we are to make the appropriate changes to confront the effects of global warming. Because solar energy is the most widely known form of renewable energy, much focus has been placed on finding quality materials with high energy outputs to replace conventional fossil fuel energy sources. To utilize sun energy for power generation, the dye synthesis solar cell, which belongs to third-generation photovoltaic technology, is likely to compete with more mature silicon technologies. This paper attempts to convey the core idea of dye-synthesized solar cells and the material used to make photoanodes. To find out the contribution of the researcher to the achievement of the dye synthesis solar cell technology, previous studies were reviewed, and the factors that influence performance were analyzed. The research shows that proper optimizations relevant to dopant, light intensity, and type of materials and a new novel approach to increasing photo-electrochemical activity in dye synthesis solar cells could make the devices compete with silicon technology.","PeriodicalId":500191,"journal":{"name":"Journal of Chemistry Studies","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136306588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0