Scholars international journal of traditional and complementary medicine最新文献

Bird’s Eye Review on Vajra: An Exquisite Carbon 金刚》鸟瞰评论精致的碳

Scholars international journal of traditional and complementary medicine Pub Date : 2024-01-18 DOI: 10.36348/sijtcm.2024.v07i01.002

Neelam Rawat, Mahesh Chandra, Usha Sharma, Khemchand Sharma

{"title":"Bird’s Eye Review on Vajra: An Exquisite Carbon","authors":"Neelam Rawat, Mahesh Chandra, Usha Sharma, Khemchand Sharma","doi":"10.36348/sijtcm.2024.v07i01.002","DOIUrl":"https://doi.org/10.36348/sijtcm.2024.v07i01.002","url":null,"abstract":"Minerals, metals and gemstones have an affluent history of being employed for their therapeutic qualities once they undergo specific processing procedures. Among these gemstones, Vajra (Diamond) stands out as it is recognized as a Rasayana due to its inherent characteristics. It has been categorized within the realm of Ratna Varga. From a chemical stance, Vajra (Diamond) is renowned as the most resilient mineral found on Earth with carbon being its predominant constituent. This article delves into an exhaustive analysis of Vajra as per classical literature. Multiple classical texts of Rasa Shastra are meticulously examined to provide an extensive account of Vajra, encompassing its Prapti sthaan (Occurrence), Paryaya (Synonyms), Vargikaran (Classification), Karma (Pharmacological properties), Ashuddha Vajra Dosha, its prativisha (antidote), Shodhana (Purification), Marana (Incineration), Matra (Therapeutic dose), Chikitisiya Prayog (Therapeutic indications) and Druti preparation (Liquefaction). While Vajra is commonly used for ornamental purposes, it also finds a distinct role in therapeutic applications after undergoing purification and incineration processes, both internally and externally.","PeriodicalId":499337,"journal":{"name":"Scholars international journal of traditional and complementary medicine","volume":"119 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Screening and Antioxidant Potential of Methanol Extract of Triumfetta cordifolia A. Rich. (Malvaceae) Leaves 马缨丹科植物Triumfetta cordifolia A. Rich.叶甲醇提取物的植物化学筛选和抗氧化潜力(锦葵科）叶

Scholars international journal of traditional and complementary medicine Pub Date : 2024-01-08 DOI: 10.36348/sijtcm.2024.v07i01.001

BamidelBae Martin Amos- Tautua, I. T. Ajoko, P. E. Oyaseiye

{"title":"Phytochemical Screening and Antioxidant Potential of Methanol Extract of Triumfetta cordifolia A. Rich. (Malvaceae) Leaves","authors":"BamidelBae Martin Amos- Tautua, I. T. Ajoko, P. E. Oyaseiye","doi":"10.36348/sijtcm.2024.v07i01.001","DOIUrl":"https://doi.org/10.36348/sijtcm.2024.v07i01.001","url":null,"abstract":"Triumfetta cordifolia is a medicinal plant that has been widely utilized in Africa for its therapeutic properties in treating various ailments. The purpose of this research was to investigate phytochemicals and in vitro antioxidant activity of the leaf extract of T. cordifolia. Standard methods were employed to conduct qualitative phytochemical screening of the plant extract. This study used the DPPH (1, 1diphenyl-2-picryl hydrazyl) radical scavenging and ferric reducing antioxidant power method to assess antioxidant activity. Phytochemical analysis of T. cordifolia leaves indicated the existence of saponins, tannins, terpenoids, cardiac glycosides, alkaloids, flavonoids but no anthraquinones. In the DPPH scavenging test, the IC50 value of the methanolic extract was discovered to be 1.29 µg/mL, and the standard reference value for ascorbic acid was 2.14 µg/mL. The leaf extract of T. cordifolia displayed stronger inhibition of DPPH activity, showing a higher potency than ascorbic acid. The DPPH scavenging activity was also shown to increase with concentration. In FRAP assay, the T. cordifolia leaf extract and the ascorbic acid revealed reducing power of 71.01±0.15 and 548.39±1.62 μM Fe2+ per mg of extract, respectively. The FRAP assay demonstrated that ascorbic acid exhibited greater antioxidant activity than the leaf extract of T. cordifolia. The presence of flavonoids and phenols in T. cordifolia leaves may account for the observed antioxidant activity. In conclusion, the study's findings suggest that that T. cordifolia leaf extract could be a source of lead compounds with promising antioxidant activity.","PeriodicalId":499337,"journal":{"name":"Scholars international journal of traditional and complementary medicine","volume":"4 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zerumbone (ZER), a Potential Anticancer for Breast Mediates Cancer Cell Death Through Targeting β-catenin Signaling Pathway in Tumor Regression in Sprague Dawley Rat Mammary Gland Tumors Zerumbone (ZER)--一种潜在的乳腺癌抗癌药物--通过靶向β-catenin 信号通路介导 Sprague Dawley 大鼠乳腺肿瘤中肿瘤细胞的死亡

Scholars international journal of traditional and complementary medicine Pub Date : 2023-12-02 DOI: 10.36348/sijtcm.2023.v06i10.002

I. Arbab, Dalia Younis Adam Haroon, Salah Eldeen H. Abdlrazig, Fath Elrahman Abaid Alla Ali, Daralsalalam Essmael Mohammed, Awad Salim Ibrahim Holy, Mohamed Qaje Adan, Mohamed A. Bakr

{"title":"Zerumbone (ZER), a Potential Anticancer for Breast Mediates Cancer Cell Death Through Targeting β-catenin Signaling Pathway in Tumor Regression in Sprague Dawley Rat Mammary Gland Tumors","authors":"I. Arbab, Dalia Younis Adam Haroon, Salah Eldeen H. Abdlrazig, Fath Elrahman Abaid Alla Ali, Daralsalalam Essmael Mohammed, Awad Salim Ibrahim Holy, Mohamed Qaje Adan, Mohamed A. Bakr","doi":"10.36348/sijtcm.2023.v06i10.002","DOIUrl":"https://doi.org/10.36348/sijtcm.2023.v06i10.002","url":null,"abstract":"Background & Objective: Canonical WNT/Wingless pathway regulates expression of target genes by modulating intracellular β-catenin leading to cancer growth and survival. Here, we studied inhibition of β-catenin using zerumbone (ZER) or β-catenin-siRNA in Sprague-Dawley rat cancer model. Methodology: Rat mammary gland tumor model was induced with the wild-type LA7 breast cancer cell line or β-catenin-knockdown-LA7 cells. LA7-rats were treated with ZER or β-catenin-siRNA as a positive control and the levels of β-catenin expression and its target gene were assessed using real-time PCR, immunohistochemistry and TUNEL assay. Results: We found good correlation between β-catenin inhibition and induction of apoptosis when using ZER or β-catenin-siRNA. In this aspect, ZER and β-catenin-siRNA inhibited cellular proliferation as reflected by reduced growth of breast cancer and apoptosis induction in rat mammary gland tumor. Further, our studies demonstrate that treatment with ZER and β-catenin-siRNA affected β-catenin-dependent gene expression. β-catenin downregulation by ZER or knockdown by β-catenin-siRNA improves the morphological and histological feature of the breast tissues as confirmed by subtle changes of the genes involved in cell-apoptotic pathways. Conclusion: This indicates that ZER targets similarly to β-catenin-siRNA and possibly be a useful anti-breast cancer by affecting expression of down-stream targets that are key components in cancer development. ZER can be a promising anticancer candidate for treatment of breast.","PeriodicalId":499337,"journal":{"name":"Scholars international journal of traditional and complementary medicine","volume":"121 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on Praval Panchamrita Rasa: A Natural Calcium Supplement 天然补钙剂Praval Panchamrita Rasa的研究进展

Scholars international journal of traditional and complementary medicine Pub Date : 2023-10-20 DOI: 10.36348/sijtcm.2023.v06i09.001

Usha Sharma, Sheenam Rani

{"title":"Review on Praval Panchamrita Rasa: A Natural Calcium Supplement","authors":"Usha Sharma, Sheenam Rani","doi":"10.36348/sijtcm.2023.v06i09.001","DOIUrl":"https://doi.org/10.36348/sijtcm.2023.v06i09.001","url":null,"abstract":"Rasashastra (Itrochemistry), is a pharmaceutical subsidiary of Ayurveda that mainly deals with formulations containing minerals/metals. Praval Panchamrita Rasa is one of them which is a very versatile Ayurvedic formulation due to its multiple indications, mainly for Vata and Kapha diseases. This formulation is a combination of five Bhasmas i.e. Praval Bhasma, Mukta Bhasma, Shankha Bhasma, Shukti Bhasma and Kapardika Bhasma which are of marine origin and is triturated with Arka Ksheer (latex of Calotropis procera L.) and subjected to incineration. The latex of Calotropis procera L. plays an important role as a reducing and capping agent resulting in the green synthesis of nanoparticles. Preval Panchamrita Rasa has been mentioned in different classical texts such as Yoga Ratnakara, Bhaishajya Ratnavali, AFI, Rasa Yoga Sagar etc. Acharyas have described this formulation as “Sarvagadapahari” i.e. it can cure all diseases. XRD study of Praval Panchamrita Rasa revealed the maximum value of calcite form of calcium carbonate, while SEM study illustrated the smaller particle size range (max size ≤6μ) resulting in higher bioavailability of Praval Panchamrita Rasa. It has also been reported that calcium in calcite form is better absorbed as compared to other forms of calcium carbonate. It is a natural source of calcium which is a necessary nutrient for the proper functioning of the human body. Calcium is a crucial element that mediates muscle contraction, exocrine, endocrine and neurocrine secretion, cell growth, transportation and secretion of fluids and electrolytes.","PeriodicalId":499337,"journal":{"name":"Scholars international journal of traditional and complementary medicine","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135665187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0