Journal of medicine and life science (Online)最新文献

Insight into the transcriptome of the small intestine in pups born from corticosterone-treated rats 对皮质酮治疗大鼠所生幼鼠小肠转录组的深入研究

Journal of medicine and life science (Online) Pub Date : 2023-09-30 DOI: 10.22730/jmls.2023.20.3.135

Eun-A Ko, Dawon Kang

引用次数: 0

Euglycemic diabetic ketoacidosis development in a patient with type 2 diabetes receiving a sodium-glucose cotransporter-2 inhibitor and a carbohydrate-restricted diet 接受钠-葡萄糖共转运蛋白-2抑制剂和限制碳水化合物饮食的2型糖尿病患者的正常血糖糖尿病酮症酸中毒

Journal of medicine and life science (Online) Pub Date : 2023-09-30 DOI: 10.22730/jmls.2023.20.3.126

Gwanpyo Koh, Jisun Bang, Soyeon Yoo, Sang Ah Lee

{"title":"Euglycemic diabetic ketoacidosis development in a patient with type 2 diabetes receiving a sodium-glucose cotransporter-2 inhibitor and a carbohydrate-restricted diet","authors":"Gwanpyo Koh, Jisun Bang, Soyeon Yoo, Sang Ah Lee","doi":"10.22730/jmls.2023.20.3.126","DOIUrl":"https://doi.org/10.22730/jmls.2023.20.3.126","url":null,"abstract":"Sodium-glucose cotransporter-2 (SGLT2) inhibitors have become increasingly prescribed because of their proven protective effects on the heart and kidneys, and carbohydrate-restricted diets are popular therapeutic approaches for patients with obesity and diabetes. A 28-year-old obese woman with recently diagnosed diabetes developed euglycemic diabetic ketoacidosis (DKA) while on dapagliflozin, an SGLT2 inhibitor, and following a carbohydrate-restricted diet. She presented with nausea, vomiting, and epigastric pain. Hospital tests showed a blood glucose of 172 mg/dL, metabolic acidosis, and increased ketone levels, confirming euglycemic DKA. Treatment involved discontinuing dapagliflozin and administering fluids, glucose, and insulin. She recovered and was discharged on the fourth day. This is considered a case of euglycemic DKA induced by SGLT2 inhibitors and triggered by a carbohydrate-restricted diet. This case highlights the importance of physicians in confirming the symptoms and laboratory results of DKA, even in patients with normal blood glucose levels taking SGLT2 inhibitors and following carbohydrate-restricted diets. It is also crucial to advise patients to maintain an adequate carbohydrate intake.","PeriodicalId":498809,"journal":{"name":"Journal of medicine and life science (Online)","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological application of the cycle threshold value of RT-PCR for estimating infection period in cases of SARS-CoV-2 RT-PCR周期阈值在SARS-CoV-2病例感染期估计中的流行病学应用

Journal of medicine and life science (Online) Pub Date : 2023-09-30 DOI: 10.22730/jmls.2023.20.3.107

Soonjong Bae, Jong-Myon Bae

{"title":"Epidemiological application of the cycle threshold value of RT-PCR for estimating infection period in cases of SARS-CoV-2","authors":"Soonjong Bae, Jong-Myon Bae","doi":"10.22730/jmls.2023.20.3.107","DOIUrl":"https://doi.org/10.22730/jmls.2023.20.3.107","url":null,"abstract":"Epidemiological control of coronavirus disease 2019 (COVID-19) is needed to estimate the infection period of confirmed cases and identify potential cases. The present study, targeting confirmed cases for which the time of COVID-19 symptom onset was disclosed, aimed to investigate the relationship between intervals (day) from symptom onset to testing the cycle threshold (CT) values of real-time reverse transcription-polymerase chain reaction. Of the COVID-19 confirmed cases, those for which the date of suspected symptom onset in the epidemiological investigation was specifically disclosed were included in this study. Interval was defined as the number of days from symptom onset (as disclosed by the patient) to specimen collection for testing. A locally weighted regression smoothing (LOWESS) curve was applied, with intervals as explanatory variables and CT values (CTR for RdRp gene and CTE for E gene) as outcome variables. After finding its non-linear relationship, a polynomial regression model was applied to estimate the 95% confidence interval values of CTR and CTE by interval. The application of LOWESS in 331 patients identified a U-shaped curve relationship between the CTR and CTE values according to the number of interval days, and both CTR and CTE satisfied the quadratic model for interval days. Active application of these results to epidemiological investigations would minimize the chance of failing to identify individuals who are in contact with COVID-19 confirmed cases, thereby reducing the potential transmission of the virus to local communities.","PeriodicalId":498809,"journal":{"name":"Journal of medicine and life science (Online)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facilitating combined upper and lower abdominal laparoscopic surgeries 促进上下腹腹腔镜联合手术

Journal of medicine and life science (Online) Pub Date : 2023-09-30 DOI: 10.22730/jmls.2023.20.3.139

Atef M.M. Darwish, Dina A.M. Darwish, Vefa Dervis, Rabih Nohman

{"title":"Facilitating combined upper and lower abdominal laparoscopic surgeries","authors":"Atef M.M. Darwish, Dina A.M. Darwish, Vefa Dervis, Rabih Nohman","doi":"10.22730/jmls.2023.20.3.139","DOIUrl":"https://doi.org/10.22730/jmls.2023.20.3.139","url":null,"abstract":"Laparoscopic procedures can be performed concurrently in a single setting. Laparoscopic entry sites for combined upper and lower abdominal surgeries are a controversial issue with no international recommendations. As the umbilicus is the optimum primary entry point for laparoscopy, it is typically used in such cases. The Darwish point was recently identified as a secure (primary) laparoscopic entry point in exceptional situations. It is a right-sided meeting point of an imaginary transverse line at the umbilical level and a vertical line 2.5 cm medial to the anterior superior iliac spine. It can subsequently serve as a right-sided auxiliary (secondary) laparoscopic entry site in some cases of combined upper abdominal (e.g., cholecystectomy, adhesiolysis) and lower abdominal laparoscopic surgeries (e.g., appendectomy, myomectomy, and ovarian cystectomy) in female patients. In such cases, an additional left-sided auxiliary (secondary) portal should be prepared laterally to the left inferior epigastric vessels, as high as possible, but below the umbilical level. In this way, both upper and lower abdominal surgeries can be easily done, with the advantage of minimizing secondary laparoscopic portal numbers and resulting in a better aesthetic appearance of the abdomen. In conclusion, the Darwish point may be used as an alternative “primary,” as well as a “secondary,” laparoscopic portal in combined upper and lower abdominal laparoscopic surgeries. Figure 1 shows the entry portals suggested for most combined upper and lower abdominal laparoscopic surgeries. We performed many combined upper and lower abdominal surgeries via this approach, with successful results in terms of ease of access to the surgical site and Journal of Medicine and Life Science","PeriodicalId":498809,"journal":{"name":"Journal of medicine and life science (Online)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous resolution of new coronary artery aneurysm following guideline-directed medical therapy after drug-eluting stent implantation 药物洗脱支架植入术后经指导药物治疗的新冠状动脉瘤自发消退

Journal of medicine and life science (Online) Pub Date : 2023-09-30 DOI: 10.22730/jmls.2023.20.3.131

Jae-Geun Lee, Ki Yung Boo

{"title":"Spontaneous resolution of new coronary artery aneurysm following guideline-directed medical therapy after drug-eluting stent implantation","authors":"Jae-Geun Lee, Ki Yung Boo","doi":"10.22730/jmls.2023.20.3.131","DOIUrl":"https://doi.org/10.22730/jmls.2023.20.3.131","url":null,"abstract":"Here, we present a case of a 56-year-old man with acute myocardial infarction. The patient underwent percutaneous coronary intervention (PCI) at the left main bifurcation and mid-left anterior descending artery using drugeluting stents. Four months after the PCI, the patient was readmitted for cardiac arrest. Coronary angiography (CAG) revealed stent thrombosis in the left main-toproximal left anterior descending artery and in-stent restenosis in the left main-toproximal left circumflex artery. We performed balloon angioplasty at the left main to mid-left anterior descending artery and left main to proximal left circumflex artery stents; subsequently, blood flow was fully restored. However, contrast agent extravasation was observed outside the mid-portion of the left main artery to the proximal left anterior descending artery stent, indicating the presence of a coronary artery aneurysm (CAA) outside the stent. After guideline-directed medical therapy with dual antiplatelet agents and high-intensity statins, follow-up CAG revealed near-resolution of the CAA, absence of stenotic lesions, and good blood flow.","PeriodicalId":498809,"journal":{"name":"Journal of medicine and life science (Online)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of monthly arteriovenous fistula flow surveillance on hemodialysis access thrombosis and loss 每月动静脉瘘流量监测对血液透析通路血栓形成和丢失的影响

Journal of medicine and life science (Online) Pub Date : 2023-09-30 DOI: 10.22730/jmls.2023.20.3.115

Ara Ko, Miyeon Kim, Hwa Young Lee, Hyunwoo Kim

{"title":"Impact of monthly arteriovenous fistula flow surveillance on hemodialysis access thrombosis and loss","authors":"Ara Ko, Miyeon Kim, Hwa Young Lee, Hyunwoo Kim","doi":"10.22730/jmls.2023.20.3.115","DOIUrl":"https://doi.org/10.22730/jmls.2023.20.3.115","url":null,"abstract":"Arteriovenous fistula flow dysfunction is the leading cause of vascular access thrombosis and loss in patients undergoing hemodialysis. However, data regarding the influence of access flow rate measurements on the long-term outcomes of access are limited. This study aims to identify accesses at a high risk of thrombosis and loss among patients undergoing hemodialysis by measuring the access flow rate and exploring an optimal threshold value for predicting future access thrombosis. We enrolled 220 patients with arteriovenous fistula undergoing hemodialysis. The primary outcome was the occurrence of access thrombosis. Access flow rates were measured monthly using the ultrasound dilution method and were averaged using all measurements from patients with patent access. In patients experienced access thrombosis, those immediately before the thrombosis were selected. Using these data, we calculated the access flow rate threshold for thrombosis occurrence by analyzing the receiver operating characteristic curve, and the patients were divided into two groups according to whether access flow rates were higher or lower than 400 mL/min. During a median follow-up period of 3.1 years, 4,510 access flows were measured (median measurements per patient, 33 times; interquartile range, 11-54). A total of 65 access thromboses and 19 abandonments were observed. Access thrombosis and loss were higher in the lowflow group than in the high-flow group. This study revealed that low access flow rates are strongly associated with access thrombosis occurrence and subsequent loss of arteriovenous fistulas in patients undergoing hemodialysis.","PeriodicalId":498809,"journal":{"name":"Journal of medicine and life science (Online)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0