Tamjeed Journal of Healthcare Engineering and Science Technology最新文献

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Impact of smoking on Galectin-3 and GDF-15 among pregnant women 吸烟对孕妇中 Galectin-3 和 GDF-15 的影响

Tamjeed Journal of Healthcare Engineering and Science Technology Pub Date : 2024-01-04 DOI: 10.59785/tjhest.v2i1.37

Ahmad Al-Rweis, Zainab Zakaraya, Laila Al-Omari, Khaled Abdul-Aziz

{"title":"Impact of smoking on Galectin-3 and GDF-15 among pregnant women","authors":"Ahmad Al-Rweis, Zainab Zakaraya, Laila Al-Omari, Khaled Abdul-Aziz","doi":"10.59785/tjhest.v2i1.37","DOIUrl":"https://doi.org/10.59785/tjhest.v2i1.37","url":null,"abstract":"In order to shed an understanding of the complicated mechanisms behind the health implications of tobacco use during pregnancy, this study examines the complex interplay between smoking and pregnancy on the levels of the biomarkers Galectin-3 and GDF-15, and to provide a comprehensive analysis, facilitating a deeper understanding and offering potential pathways for targeted interventions to mitigate health risks. Pregnant smokers had higher levels of hemoglobin and white blood cell counts, while both pregnant groups had lower platelet counts. Additionally, pregnant smokers had higher levels of total cholesterol, LDL, triglycerides, liver enzymes (ALT and AST), and C-reactive protein. These significant changes in hematological and metabolic parameters were found in a cross-sectional analysis involving 90 female participants who were divided into three groups: pregnant smokers, pregnant non-smokers, and non-pregnant non-smokers. Although there were slight variations in the levels of GDF-15 and Galectin-3 between the groups, they did not reach statistical significance. These results highlight the extensive and harmful metabolic alterations brought on by smoking during pregnancy, highlighting the need for focused actions to protect the health of both the mother and the fetus even in the face of largely stable biomarker levels.","PeriodicalId":498266,"journal":{"name":"Tamjeed Journal of Healthcare Engineering and Science Technology","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Early Genes and Gene Editing Technology Associated with Clustered Repeats on the Development of Human Body Organs 与成簇重复序列相关的早期基因和基因编辑技术对人体器官发育的影响

Tamjeed Journal of Healthcare Engineering and Science Technology Pub Date : 2024-01-04 DOI: 10.59785/tjhest.v2i1.44

Alaa Shaheen

{"title":"The Impact of Early Genes and Gene Editing Technology Associated with Clustered Repeats on the Development of Human Body Organs","authors":"Alaa Shaheen","doi":"10.59785/tjhest.v2i1.44","DOIUrl":"https://doi.org/10.59785/tjhest.v2i1.44","url":null,"abstract":"Early growth response 1 (EGR-1) and homeobox (Hox) proteins play crucial roles in regulating genes within the body, promoting cell renewal, and expediting the wound healing process. Conversely, Clustered Regularly Interspaced Palindromic Re-peats/Associated (CRISPR-Cas) technology is primarily involved in gene editing. However, significant gaps persist in understanding the mechanisms of key genes like EGR-1, CRISPR/Cas, and HOX genes in organ development. Unveiling their mechanisms is crucial for advancing organ development and discovering new therapeutic strategies. This study aims to investigate the roles of EGR-1, CRISPR/Cas, and HOX genes in organ development and growth. The study used CRISPR/Cas to investigate the impact of catalase mutations on organ regeneration. Early embryonic mutants were generated by injecting gRNAs and Cas9 protein into zygotes, followed by tail amputation in larvae. Additionally, the study explored the role of specific Hox genes in axon elongation and Wnt signaling regulation. EGR-1, induced by TGF-β1, enhanced collagen production, underscoring its importance in wound healing. Integration of EGR-1, HOX proteins, and CRISPR-Cas revealed a regulatory complex influencing organ development. The integration of EGR-1, HOX proteins, and CRISPR-Cas revealed a regulatory complex. EGR-1 aids wound healing, HOX proteins influence fetal development and organ formation, and CRISPR-Cas enables precise genome modifications.","PeriodicalId":498266,"journal":{"name":"Tamjeed Journal of Healthcare Engineering and Science Technology","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of trauma patients with multidrug-resistant bacteria from an epidemiological, clinical, and microbiological perspective 从流行病学、临床和微生物学角度分析创伤患者多重耐药菌的特点

Tamjeed Journal of Healthcare Engineering and Science Technology Pub Date : 2023-08-04 DOI: 10.59785/tjhest.v1i2.20

Saja Sumiea Anaz, Alnoman Mundher Tayyeh

{"title":"Characteristics of trauma patients with multidrug-resistant bacteria from an epidemiological, clinical, and microbiological perspective","authors":"Saja Sumiea Anaz, Alnoman Mundher Tayyeh","doi":"10.59785/tjhest.v1i2.20","DOIUrl":"https://doi.org/10.59785/tjhest.v1i2.20","url":null,"abstract":"Trauma, healthcare-associated infections, and antimicrobial resistance are three major public health issues worldwide due to the high probability of patient morbidity and, ultimately, a tragic outcome. In the current study included all patients admitted to The NRI Medical College Hospital, (Mangalagiri, Andhra Pradesh, India) intensive care units between May 1, 2021 and August 31, 2022. Patients with first bacteremia were found to have MRSA, VRE, and carbapenem-resistant Gram-negative bacteria. We included 1528 patients, 302 of whom had trauma and 66 (4.3%) of whom had MR-agent-induced bacteremia. Mechanical ventilation, renal replacement therapy, and surgery were all independent risk factors for MR agent bacteremia. In the trauma cohort, haemodialysis alone was associated with an increased risk of MR agent bacteremia. S. aureus, MRSA (n=27), and K. pneumoniae (n=26) were the two most common isolating agents. The blaKPC gene was found in 83% of the K. pneumoniae strains (while the NDM gene was found in only one). Injuries have no effect on the development of bacteremia caused by MR agents. Certain risk factors appear to be associated with the severity of MR bacteremia cases. ","PeriodicalId":498266,"journal":{"name":"Tamjeed Journal of Healthcare Engineering and Science Technology","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136143803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1