한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230011

Hong-Sik Kong, Yoonseok Lee

{"title":"Functional in silico analysis of a non-synonymous SNP located in the coding region of the FASN gene in Korean native cattle","authors":"Hong-Sik Kong, Yoonseok Lee","doi":"10.12972/jabng.20230011","DOIUrl":"https://doi.org/10.12972/jabng.20230011","url":null,"abstract":"Bovine fatty acid synthase, an enzyme encoded by the FASN gene in cattle, is a multi-enzyme protein that catalyses fatty acid synthesis. This cytosolic enzyme catalyzes the synthesis of palmitate from acetylcoenzyme A and malonyl-coenzyme A in the presence of nicotinamide adenine dinucleotide phosphate (NADPH). However, there is no previous verification study that each allele of SNPs related to lipid synthesis were impact on protein function in Korean native cattle and nsSNPs for the FASN gene have not yet been verified by computer analysis. Given the role of the FASN gene in beef quality traits in cattle, the study aimed to use computational analysis to narrow down the candidate nsSNPs for FASN that may affect protein structure and/or function, which may play an important role in lipid synthesis. These results predicted that the g.16039 T>C nsSNP at position R1957Y of FASN was functionally 'Deleterious' and 'PROBABLY DAMAGING' in non-synonymous SNP functional analysis, and the g.16039 T>C and g.17924 A>G nsSNPs at positions R1957Y and T2266A decrease the stability of a FASN protein and have two PTM sites for proteolytic cleavage and amidation. In addition, the R1957Y and T2266A variants of FASN were shown to have a direct effect on altering the protein structure. Therefore, we suggested that our results could be used as fundamental data for further studies related to functional verification of nsSNPs based on bovine cells.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution analysis of carcass traits on auction price for Hanwoo steers in the Yeongnam region of Korea 韩国岭南地区韩牛胴体性状对拍卖价格的贡献分析

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230009

Chanbin Lee, Kyung tae Min, Seung jae Lee, Hosung Lee, Jakyeom Seo, Myunghoo Kim, Byeong-Woo Kim

{"title":"Contribution analysis of carcass traits on auction price for Hanwoo steers in the Yeongnam region of Korea","authors":"Chanbin Lee, Kyung tae Min, Seung jae Lee, Hosung Lee, Jakyeom Seo, Myunghoo Kim, Byeong-Woo Kim","doi":"10.12972/jabng.20230009","DOIUrl":"https://doi.org/10.12972/jabng.20230009","url":null,"abstract":"In this study, Data were the carcass grade on each 53,829 head of hanwoo steers slaughtered 3 years before (2017, 2018, 2019), 32,910 head of hanwoo steers slaughtered after (2020, 2021, 2022) COVID-19 at Yeongnam region and 54,369 head of hanwoo steers slaughtered same period at except for Yeongnam region. To find out the contribution of carcass traits to auction price and total price were analyzed through regression coefficients by using multiple regression analysis. As environmental factors affecting these carcass traits, slaughter year and slaughter season were set and analyzed through the least square method. The results of slaughter year showed that the grade of carcass traits in Yeongnam region increased over the years. In addition, in the slaughter season, the grade of carcass traits in the fall was found to be excellent. According to the contribution analysis, the results of the contribution ratio to auction price of before and after COVID-19 in Yeongnam region and after COVID-19 in all regions except Yeongnam were the same in order of marbling score, backfat thickness, eye muscle area, carcass weight. Also, the contribution ratio to total price were the same in order of carcass weight, marbling score, backfat thickness, eye muscle area. The general carcass grade is intended to use and analyze data from Yeongnam region, which has excellent backfat thickness and carcass weight, also has the largest number of elite cows selected through the verification work of elite cow by Korea Animal Improvement Association, and use it as a means for strategies to increase farm’s income and advance to high quality about Korean beef.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"167 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on searching for candidate genes associated with pH concentration in Hanwoo meat using GWAS(genome-wide association study) and functional analysis 利用GWAS(全基因组关联研究)和功能分析寻找韩雨肉品pH浓度相关候选基因的研究

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230008

Do Hyun Kim, Jae Don Oh

{"title":"A study on searching for candidate genes associated with pH concentration in Hanwoo meat using GWAS(genome-wide association study) and functional analysis","authors":"Do Hyun Kim, Jae Don Oh","doi":"10.12972/jabng.20230008","DOIUrl":"https://doi.org/10.12972/jabng.20230008","url":null,"abstract":"This study was conducted to explore the genomic information significantly associated with the pH concentration of Hanwoo meat and to perform functional interpretation of the candidate genes. pH concentrations were measured from 135 samples of Hanwoo, and SNP information was generated using the Hanwoo GeneChip v1. The phenotype of pH concentration and SNP information were used in GWAS (Genome-Wide Association Study). A total of 44 significant SNPs were detected in the analysis (p-value < 0.001). Chromosome 29 had the highest number of significant SNPs (6 SNPs), Chromosome 7 with the second-highest number (5 SNPs). Gene ontology (GO) and KEGG pathway analysis using DAVID identified 3 significant GO terms in Biological Process and 1 in Cellular Component. Additionally, a total of 2 pathways were identified through KEGG analysis. The significant candidate genes were found to be closely associated with the regulation of phosphorylase enzymes or mitochondrial energy production functions. These research findings are expected to be useful data for future development of digital breeding technologies.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copy Number Variation Frequency Analysis by Regions of Hanwoo (Korean Native Cattle) Using Hanwoo SNP 50K Chip 利用Hanwoo SNP 50K芯片分析韩国地方牛拷贝数变异频率

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230013

Khaliunaa Tseveen, Gwang Hyeon Lee, Chan Mi Bang, Dae Yong Yang, Chang Wan Sun, Yoon Seok Lee, Hong Sik Kong

{"title":"Copy Number Variation Frequency Analysis by Regions of Hanwoo (Korean Native Cattle) Using Hanwoo SNP 50K Chip","authors":"Khaliunaa Tseveen, Gwang Hyeon Lee, Chan Mi Bang, Dae Yong Yang, Chang Wan Sun, Yoon Seok Lee, Hong Sik Kong","doi":"10.12972/jabng.20230013","DOIUrl":"https://doi.org/10.12972/jabng.20230013","url":null,"abstract":"Recently another type of genetic polymorphism, called copy number variation (CNV), has been discovered in the whole genome variation. SNP chips have also been used for CNVs analysis, making them a useful analytical tool. In this study, we evaluated CNVs and identified the relationship between CNV regions (CNVRs) in Hanwoo (n=1500) using the Illumina Hanwoo SNP 50K BeadChip in four South Korean regions. PennCNV software was used to identify CNVs, followed by CNV Ruler software to locate diverse CNVRs. We identified 8686 CNVs (6666 gains; 2020 loss), with lengths varying from 2,182 to 2,957,803 bp. Additionally, 689 CNVRs (480 gains; 153 losses; 56 both) were identified, with lengths varying from 2,820 to 2,957,803 bp, with an average of 124,881 bp, encompassing 86,042,896 bp (3.48%). Bioinformatic analysis was conducted using Biomart tools, gene ontology analysis, and the DAVID program. We identified 27 genes that were associated with IGF2, INS, SOCS3, and TH and found that they were related to insulin (GO:0046626, GO:1900076, bta04917). In conclusion, CNVs were identified using the HanwooSNP50k chip, CNVR with characteristics for each region was identified, and a part overlapping with the gene was verified. It is essential to verify that insulin-related genes differ by region and to understand the relationship between regional economic traits and CNV.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of environmental effects and estimation of genetic parameters for carcass traits in Hanwoo steers produced through embryo transfer 胚胎移植汉宇阉牛胴体性状的环境效应分析及遗传参数估算

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230014

Du Won Sun, Eun Ho Kim, Hyeon Kwon Kim, Il Keun Kong, Jung Gyu Lee, Hyun Tae Lim

{"title":"Analysis of environmental effects and estimation of genetic parameters for carcass traits in Hanwoo steers produced through embryo transfer","authors":"Du Won Sun, Eun Ho Kim, Hyeon Kwon Kim, Il Keun Kong, Jung Gyu Lee, Hyun Tae Lim","doi":"10.12972/jabng.20230014","DOIUrl":"https://doi.org/10.12972/jabng.20230014","url":null,"abstract":"This study estimated the environmental effects and genetic parameters for carcass traits of 2,309 Hanwoo steers produced through Embryo Transfer (ET) to confirm the performance improvement achieved. The data used for analysis collected information on offspring produced by ET from 2012 to 2020. SAS 9.4 GLM package was used to analyze the environmental effects affecting carcass traits, and genetic parameters were estimated using the REMLF90 program for heritability, genetic correlation, and phenotypic correlation. The collected Carcass Weight (CWT), Eye Muscle Area (EMA), Back-Fat Thickness (BFT), and Marbling Score (MS) were 505.2±58.19kg, 105.57±13.41cm2, 12.76±4.27mm, and 7.25±1.61 points, respectively. It was found that the environmental effect of growth area and slaughter month had a significant effect (p<0.01) on carcass traits. Heritability was 0.51, 0.64, 0.36, and 0.59 in CWT, EMA, BFT, and MS, respectively, and high heritability was observed in all traits except BFT. Due to the characteristics of ET, it is considered that the effect of genetic improvement was more pronounced because there were many offspring with the same parents or the same father or mother. Therefore, it is judged that more efficient improvement effect and performance can be confirmed if an optimal environmental model is set based on the results of this study and used as basic data for breeding. If these results continue to accumulate, it is thought that it will be able to contribute to the increase in farm household income through the improvement effect.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular evidence for occurrence of endangered long-tailed goral in Seoul metropolitan city, South Korea 韩国首尔市濒危长尾白喉发生的分子证据

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230010

Hye-Ri Kim, Jae-Bong Lee, Sang-Min Jeong, Tae-Wook Kim, Jang-Ick Son, Jeong-Joo Youn, Sang-Hyun Han

{"title":"Molecular evidence for occurrence of endangered long-tailed goral in Seoul metropolitan city, South Korea","authors":"Hye-Ri Kim, Jae-Bong Lee, Sang-Min Jeong, Tae-Wook Kim, Jang-Ick Son, Jeong-Joo Youn, Sang-Hyun Han","doi":"10.12972/jabng.20230010","DOIUrl":"https://doi.org/10.12972/jabng.20230010","url":null,"abstract":"The study examined the habitation and the number of long-tailed gorals by molecular identification, sexing discrimination, and identity tests on feces and hair samples estimated to be endangered long-tailed goral in Mt. Yongmasan, Mt. Achasan and Mt. Inwangsan near Seoul metropolitan city. Mitochondrial cytochrome oxidase I (COI) gene sequences showed that the DNA samples from the three mountains were those of long-tailed goral (Naemorhedus caudatus). The molecular sexing results showed that there were a female and a male in Mt. Yongmasan, a male in Mt. Achasan, but no informative results for Mt. Inwangsan. The identity test results indicated that the males of Mt. Yongmasan and Mt. Achasan were the same male, estimating the shift of this male from Mt. Yongmasan to Mt. Achasan. In addition, the goral of Mt. Inwangsan had a different COI sequence from those of Mt. Yongmasan and Mt. Achasan estimated to be this male with a different maternal lineage. Our present findings provide molecular evidence that at least three gorals have been inhabiting or continuously visiting the mountainous areas of Seoul metropolitan city, suggesting that a management system may be necessary for protecting this natural habitat of endangered long-tailed goral.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the status and trends of the carbon footprint of Hanwoo steers by region 韩宇汽车碳足迹的区域现状与趋势研究

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230012

Do Hyun Kim, Ji Suk Yu, Hak Kyo Lee, Jae Don Oh

引用次数: 0

Estimation the genetic parameters and evaluating the correlation between the maternal linear type traits and the birth weight of the progeny in Hanwoo cows 估计了韩宇奶牛母系线性型性状的遗传参数，并评价了母系线性型性状与后代出生体重的相关性

한국동물유전육종학회지 Pub Date : 2023-09-30 DOI: 10.12972/jabng.20230007

Jae Kwang Noh, Sung Jin Kim, Ji Hyun Son, Tae Jeong Choi, Chang Hee Do, Yang-Mo Koo

{"title":"Estimation the genetic parameters and evaluating the correlation between the maternal linear type traits and the birth weight of the progeny in Hanwoo cows","authors":"Jae Kwang Noh, Sung Jin Kim, Ji Hyun Son, Tae Jeong Choi, Chang Hee Do, Yang-Mo Koo","doi":"10.12972/jabng.20230007","DOIUrl":"https://doi.org/10.12972/jabng.20230007","url":null,"abstract":"This study aimed to investigate the correlation between the linear type traits of mother cows (dams) and the birth weight(BW) of the progeny. The study used data collected between 2002 and 2018 by the Korea Animal Improvement Association (KAIA). This study evaluated the data specifically with respect to 19 traits. A statistical model was established to estimate the correlation between the maternal linear classification traits and the progeny BW. The significance of each statistical variable was analyzed using the generalized linear model (GLM) method in the SAS package 9.1.3 software, while the genetic parameters were estimated using the BLUPF90 Family program. The BW of Hanwoo cows increased by approximately 0.4 kg each year; however, the BW heritability was moderate (0.23). The linear classification traits showed values of 0.34, 0.37, 0.11, 0.45, 0.31, and 0.40, for ST (Vertical distance from the apex of the rump to the ground), BL (Horizontal distance between anterior shoulder point to the posterior extremity of the pin bone), RA (The slope from the rump to the pin bone), RL (Horizontal distance from the anterior rump to the tip of the pin bone), PBW (Lateral width of pin bone), and FS (Final score), respectively, with moderate heritability for all traits, except RA. The BW of the progeny showed phenotypic correlations of 0.06, -0.01, 0.03, and 0.04, and genetic correlations of 0.09, 0.03, 0.02, and -0.04 with ST, BL, RL, and PBW, respectively. The average parity in Hanwoo cows increased from 2.5 in 2016 to 2.8 in June 2020. There is a low genetic correlation between the maternal linear classification traits and the BW of the progeny. An increase in the parity of dams and a greater accumulation of progeny BW data and test records could lead to the accurate evaluation of the BW as a breeding objective trait.","PeriodicalId":497906,"journal":{"name":"한국동물유전육종학회지","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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