Ioana G. Lupescu, Cristina Al. Nicolae, Mihai Pomohaci, Cristian Anghel, Mugur C. Grasu
{"title":"IRM multiparametrică cu acid gadoxetic (Primovist®) la pacienţii oncologici: indicaţii curente şi utilitatea fazei hepatobiliare","authors":"Ioana G. Lupescu, Cristina Al. Nicolae, Mihai Pomohaci, Cristian Anghel, Mugur C. Grasu","doi":"10.26416/onhe.64.3.2023.8770","DOIUrl":"https://doi.org/10.26416/onhe.64.3.2023.8770","url":null,"abstract":"Gadoxetic acid, or Gd-EOB-DTPA (Primovist®), is a magnetic resonance imaging (MRI) hepatospecific T1-positive contrast material used to evaluate the hepatobiliary region and its disorders. In this article, we review the MRI protocols with Primovist®, the importance of the hepatobiliary phase, and the current clinical indications of Primovist® in oncological patients evaluated using multiparametric MRI.","PeriodicalId":496621,"journal":{"name":"Oncolog-Hematolog.ro","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mihai Adrian Păsărică, Christiana Diana Maria Dragosloveanu, Paul Filip Curcă, Alina Ciocâlteu, Alexandru C. Grigorescu
{"title":"Ultrasonografia în melanomul coroidal necrotic","authors":"Mihai Adrian Păsărică, Christiana Diana Maria Dragosloveanu, Paul Filip Curcă, Alina Ciocâlteu, Alexandru C. Grigorescu","doi":"10.26416/onhe.64.3.2023.8778","DOIUrl":"https://doi.org/10.26416/onhe.64.3.2023.8778","url":null,"abstract":"Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, originating in the uveal tract of the ocular globe. Spontaneous necrosis of choroidal melanomas is very rare, but some UMs may be predisposed to spontaneous necrosis due to rapid growth. The diagnosis of an extensively necrotic uveal melanoma can be challenging, because the associated intraocular hemorrhage makes impossible the direct tumor visualization during ophthalmoscopy. Ultrasonography is an imagistic tool based on sending and receiving sound waves (frequency above 20,000 Hz) with a probe which contains a piezoelectric transducer and works like a transmitter and receiver of sound waves in the same time. Ocular ultrasonography is the most commonly used imaging technique for determining the presence of a uveal melanoma, especially in opaque ocular media when dilated fundus examination of the eye cannot be made. In ophthalmology, we use two types of sound waves: an A-mode scan which uses frequencies of 8 MHz, and a B-mode scan for the visualization of intraocular structures which uses frequencies of 10 MHz. Ocular ultrasonography has many advantages in clinical practice, due to availability, no exposure to radiation and to low price. This article presents the difficulties associated with the diagnosis of necrotic uveal melanoma in the absence of fundus eye examination due to ocular opaque media. In this case, we should do the differential diagnosis with other pathologies that could resemble echographically uveal melanoma. In cases when ultrasonography cannot establish a clear diagnosis, we should use ancillary test.","PeriodicalId":496621,"journal":{"name":"Oncolog-Hematolog.ro","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Crampele musculare la pacienţii oncologici – un motiv de a sări din pat","authors":"Sorin Buga, Andrada Totoran, Joan Chung","doi":"10.26416/onhe.64.3.2023.8769","DOIUrl":"https://doi.org/10.26416/onhe.64.3.2023.8769","url":null,"abstract":"Muscle cramps are quite often seen in the cancer patient, which could be caused either by the cancer itself, or by the undesirable side effects of cancer therapy. It is a frequently ignored symptom, even though it could be associated with an unsuspected underlying pathologic condition. Currently, no preventive treatments for cancer-associated muscle cramp are available, and the treatment for this symptom is nonspecific, with research being done mostly on noncancer population. Therefore, more research is needed to elucidate both the pathophysiology and the therapeutic options for muscle cramps in the oncological patient.","PeriodicalId":496621,"journal":{"name":"Oncolog-Hematolog.ro","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alina Mititelu, Minodora Onisâi, Anca Nicolescu, Ioachim Preda-Naumescu, Ana Maria Vlădăreanu
{"title":"Managementul actual al trombocitopeniei imune recăzute/refractare","authors":"Alina Mititelu, Minodora Onisâi, Anca Nicolescu, Ioachim Preda-Naumescu, Ana Maria Vlădăreanu","doi":"10.26416/onhe.64.3.2023.8777","DOIUrl":"https://doi.org/10.26416/onhe.64.3.2023.8777","url":null,"abstract":"Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder characterized by antibody mediated platelet destruction and impaired platelet production. Adult patients often present with a chronic disease, displaying a stable platelet count and a low risk for bleeding. However, there is a small category of ITP patients who have instable platelet count, are at high risk for bleeding and are refractory to all forms of treatment. Immune thrombocytopenia is a diagnosis of exclusion; extensive diagnostic work is needed in order to classify a patient as having refractory ITP. Refractory patients do not respond to steroids, i.v. immunoglobulins, thrombopoietin receptor agonists (TPO-RA) or rituximab, or to any other form of treatment. Combination therapy has been evaluated in small cases, with varying results. Newer treatments – fostamatinib, FcRn or Bruton kinase (BTK) inhibitors – appear to be more effective. Exploring the biology of refractoriness is essential for understanding the complex pathology of this disease and for finding ways to stop its natural evolution. In summary, refractory immune thrombocytopenia is a complex condition that requires precise diagnosis and the initiation of an effective combination treatment from onset.","PeriodicalId":496621,"journal":{"name":"Oncolog-Hematolog.ro","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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