African ScientistPub Date : 2023-06-30DOI: 10.26538/africanscientist.24.2.202306016
Israel O. Efejene, Osuvwe Orororo, Othuke b Odeghe, Efetoboh Ejevwo
{"title":"Effect of Ethanolic Extract of Zingiber Officinale Rhizome on Blood Glucose Level in Glucose-induced Hyperglycaemic Wistar Rats","authors":"Israel O. Efejene, Osuvwe Orororo, Othuke b Odeghe, Efetoboh Ejevwo","doi":"10.26538/africanscientist.24.2.202306016","DOIUrl":"https://doi.org/10.26538/africanscientist.24.2.202306016","url":null,"abstract":"This study determined the effects of Zinger officinale Rhizome ethanolic extract on blood glucose levels in hyperglycemic Wistar rats. Twenty five adult male Wistar (150±8 g) with an average blood sugar level of 145 mg/dL were used for the study. They are divided into five treatment groups: Group A (Glucose Control – 1 g/kg bwt), Group B (Zinger officinale Rhizome extract low dose - ZOREL – 100 mg/kg bwt), Group C (Zinger officinale Rhizome extract medium dose -ZOREM – 250 mg/kg bwt), and Group D (Zinger officinale Rhizome extract high dose – ZOREH – 500 mg/kg bwt). Rats in groups B through D also received glucose (as in Group A) to cause hyperglycemia. The extracts were administered within an interval of 1-2 h for a period of ten days. Oral glucose tolerance and fasting blood glucose levels were assessed. Plasma glucose levels increased as a result of experimentally creating hyperglycemia by ingesting glucose orally. However, when the extract was given to the rats, their blood glucose levels significantly dropped. Rats administered ZOREH (Group D) on a 360-minute schedule showed the greatest decrease. At 370 minute into the experiment, ZOREL induced a reduction in blood glucose levels of 17.039%, whereas ZOREM and ZOREH generated reductions of 18.03% and 16.07% respectively. Similarly, rats given the extract (Groups B-D) had considerably lower fasting blood 5 to 10 days of glucose induction indicating that the extract enhanced the utilization of glucose. The findings suggest that ingesting Zingiber officinale rhizome extract in sufficient amounts can stabilize blood sugar levels in hyperglycemic rats.","PeriodicalId":495271,"journal":{"name":"African Scientist","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
African ScientistPub Date : 2023-06-30DOI: 10.26538/africanscientist.2.202306017
Lawson Onojake, Kingsley E. Apuyor, Stanley E. Apuyor
{"title":"Production of Carboxymethyl Cellulose (CMC) From Rubber Seed (Hevea brasiliensis) Shells","authors":"Lawson Onojake, Kingsley E. Apuyor, Stanley E. Apuyor","doi":"10.26538/africanscientist.2.202306017","DOIUrl":"https://doi.org/10.26538/africanscientist.2.202306017","url":null,"abstract":"Carboxymethyl cellulose (CMC) is a cellulose derivative utilized as a thickener in food processing, as well as in non-food items including paints and detergents. In this study, CMC was produced from cellulose which was obtained from rubber seed shells (RSS). The CMC was produced from cellulose by mercerization with 30% sodium hydroxide (NaOH) solution and etherified using monochloroacetic acid. Fourier transform infra-red (FTIR) spectroscopy was used to characterize the CMC produced therein. The amount of cellulose extracted from RSS was 55.15 %. The broad spectrum of the FTIR indicated the presence of hydroxyl, ether and carboxyl functional groups at 3442.00 cm-1, 1420 cm-1, and 1625 cm-1 respectively. These results showed favourable comparisons with the commercial CMC, which demonstrates that RSS is a promising raw material for the manufacture of CMC.","PeriodicalId":495271,"journal":{"name":"African Scientist","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}