Cancer Science最新文献_第6页

RETRACTION: Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2. 撤回：在表达乙型肝炎病毒x蛋白的细胞中p53的再激活涉及p53磷酸化和Hdm2的减少。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-09-01 Epub Date: 2026-06-24 DOI: 10.1111/cas.70454

{"title":"RETRACTION: Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2.","authors":"","doi":"10.1111/cas.70454","DOIUrl":"10.1111/cas.70454","url":null,"abstract":"Retraction: J.-H. Wang, C. Yun, S. Kim, S. Chae, Y. I. Lee, W.-H. Kim, J.-H. Lee, W. Kim and H. Cho, \"Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2,\" Cancer Science 99, no. 5 (2008): 888-893, https://doi.org/10.1111/j.1349-7006.2008.00754.x. The above article, published online on 24 February 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama; the Japanese Cancer Association; and John Wiley & Sons Australia Ltd. The retraction has been agreed following concerns raised by a third party. An investigation identified multiple instances of image duplication between the Chang and ChangX-34 α-tubulin bands shown in Figure 1a. Further duplications were identified between the HeLa α-tubulin bands in Figure 1a and the Dox α-tubulin bands in Figure 3a. In addition, the cytosol phospho-p53 (Ser 15), Lamin B, and nuclear α-tubulin panels in Figure 4a were found to have identical backgrounds. The authors were contacted for their comments and supporting data. Due to the time that has elapsed since publication, the data are no longer available. The authors do not agree that the western blot bands or panels were duplicated. The editors consider the results and conclusions to be unreliable. The authors H. Cho and J.-H. Wang disagree with the retraction. The remaining authors did not respond to our notice of retraction.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":"2602"},"PeriodicalIF":4.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response. 金丝桃素通过AKT自噬降解和诱导抗肿瘤免疫反应抑制肝癌。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-09-01 Epub Date: 2026-07-02 DOI: 10.1111/cas.70453

Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao

{"title":"Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response.","authors":"Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao","doi":"10.1111/cas.70453","DOIUrl":"10.1111/cas.70453","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy and the third leading cause of cancer-related deaths worldwide, with high mortality and limited clinical treatment options. In this study, we identified hypericin as a potent inducer of HCC cell death by screening traditional Chinese Medicine Monomer Library screening. Hypericin, a natural photosensitizer derived from Hypericum perforatum, significantly inhibited the proliferation, migration, and colony formation of HCC cell lines, and induced apoptosis in vitro. In vivo, hypericin effectively suppressed tumor growth in Hepa1-6 subcutaneous tumor and AKT/c-Myc-driven orthotopic mouse HCC models. Flow cytometry analysis revealed that hypericin treatment increased the CD8+ T cell proportion and activity within the tumor microenvironment. Combination therapy with hypericin and anti-PD-L1 antibody resulted in significant tumor growth inhibition and prolonged survival. Mechanistically, hypericin promoted the interaction between AKT and HSPA5, leading to autophagic degradation of AKT. This process inhibited the AKT/mTOR/S6 signaling pathway, downregulated the expression of downstream anti-apoptotic proteins MCL-1 and XIAP, and triggered mitochondria-mediated apoptosis in HCC cells.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":"2567-2585"},"PeriodicalIF":4.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Transcriptomics and Bulk RNA-Seq Analysis Revealed Molecular Classification of Invasive Lobular Carcinoma. 空间转录组学和大量RNA-Seq分析揭示了浸润性小叶癌的分子分类。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-09-01 Epub Date: 2026-05-21 DOI: 10.1111/cas.70413

Momoko Tokura, Jun Nakayama, Hironori Suzuki, Mieko Ochi, Miyaka Umemori, Sho Shiino, Masayuki Yoshida, Shin Takayama, Yasushi Yatabe, Yusuke Yamamoto

{"title":"Spatial Transcriptomics and Bulk RNA-Seq Analysis Revealed Molecular Classification of Invasive Lobular Carcinoma.","authors":"Momoko Tokura, Jun Nakayama, Hironori Suzuki, Mieko Ochi, Miyaka Umemori, Sho Shiino, Masayuki Yoshida, Shin Takayama, Yasushi Yatabe, Yusuke Yamamoto","doi":"10.1111/cas.70413","DOIUrl":"10.1111/cas.70413","url":null,"abstract":"Invasive lobular carcinoma (ILC) is a special type of breast cancer. The histological subtypes of ILC exhibit diverse morphological features, and the prognosis differs accordingly. Compared with patients with classic-ILC (C-ILC), patients with pleomorphic-ILC (P-ILC) have a worse prognosis, owing to high-grade nuclear atypia and mitotic cells. However, the molecular differences between C-ILC and P-ILC remain unclear. To address this gap, we performed spatial transcriptomic profiling on four fresh-frozen C-ILC samples and four fresh-frozen P-ILC samples, followed by confirmation of reproducibility in bulk RNA-seq datasets. We identified significant enrichment of cellular response to heat stress in P-ILC. Furthermore, molecular clustering analysis using genes differentially expressed across ILC samples in spatial transcriptome revealed that ILC has three molecular subtypes: proliferative (PR), immunoreactive (IM), and stroma-rich (ST), associated with distinct prognostic outcomes. Although these molecular subtypes did not completely correspond to C-ILC or P-ILC, PR tended to include P-ILC, and ST tended to include C-ILC. These molecular clusters exhibited features comparable to previously reported subtypes. Despite these phenotypic features, ILC is generally treated similarly to invasive ductal carcinoma (IDC), with limited consideration of molecular subtype classification. Our findings suggest that molecular profiling may more accurately reflect prognosis than conventional histological classification and may provide potential diagnostic markers and therapeutic targets.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":"2586-2601"},"PeriodicalIF":4.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adding Intratumoral Antibody-Photoabsorber Conjugate Improves Efficacy of Near-Infrared Photoimmunotherapy (NIR-PIT). 瘤内添加抗体-光吸收剂偶联物提高近红外光免疫治疗（NIR-PIT）的疗效。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-30 DOI: 10.1111/cas.70518

Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L Choyke, Hisataka Kobayashi

{"title":"Adding Intratumoral Antibody-Photoabsorber Conjugate Improves Efficacy of Near-Infrared Photoimmunotherapy (NIR-PIT).","authors":"Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L Choyke, Hisataka Kobayashi","doi":"10.1111/cas.70518","DOIUrl":"10.1111/cas.70518","url":null,"abstract":"Near-infrared photoimmunotherapy (NIR-PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near-infrared light in an antibody-photoabsorber conjugate (APC) bound to the cognate target antigen on the tumor cell surface. NIR-PIT has already been clinically applied in Japan to head and neck cancer patients using an anti-EGFR antibody-IR700 dye conjugate, with very promising results. Furthermore, preclinical studies have shown favorable results across many targets and cancer types. To date, APC administration in NIR-PIT has been performed via intravenous injection. However, some systemic administrations cause side effects. Therefore, local intratumoral injections might be a viable alternative in some cases. Thus, this study aimed to investigate the therapeutic effects of NIR-PIT following intratumoral administration of APC (IT-PIT) compared with NIR-PIT following intravenous administration of APC (IV-PIT) in various animal models and targets. Intratumoral administration of APC resulted in significantly greater distribution in the target tumor and less in non-tumor organs, showing that the APC can be efficiently delivered to tumor cells by intratumoral administration. In immunodeficient mice, IT-PIT showed similar efficacy to IV-PIT, despite a reduced dose of APC. In immunocompetent mice, IT-PIT showed a significant effect and extended survival, demonstrating the activation of antitumor immunity, comparable to that of IV-PIT. These results indicate that IT-PIT and IV-PIT are similarly effective in both direct cell killing and in inducing anticancer immune activation, suggesting that intratumoral administration of APC might be a promising new approach in NIR-PIT.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Resistin facilitates metastasis of lung adenocarcinoma through the TLR4/Src/EGFR/PI3K/NF-κB pathway". 修正“抵抗素通过TLR4/Src/EGFR/PI3K/NF-κB通路促进肺腺癌转移”。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-27 DOI: 10.1111/cas.70515

引用次数: 0

The Role of IGF2BP3-Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer. igf2bp3介导的免疫反应激活在加强胃毒明免疫治疗胃癌中的作用。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-25 DOI: 10.1111/cas.70514

Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng

{"title":"The Role of IGF2BP3-Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer.","authors":"Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng","doi":"10.1111/cas.70514","DOIUrl":"10.1111/cas.70514","url":null,"abstract":"Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC-I downregulation, yet strategies to restore MHC-I expression remain limited. Here, using the natural alkaloid koumine as a chemical probe, we identified IGF2BP3 as a druggable regulator of MHC-I antigen presentation. Network pharmacology, proteomics, surface plasmon resonance, and cellular thermal shift assays were used to identify and validate koumine's target. Genetic rescue experiments, loss-of-function studies, in vitro T-cell co-culture assays, and in vivo gastric cancer mouse models were performed to confirm the causal relationship. m6A-seq and ChIP-seq analyses delineated the downstream epigenetic pathway. Koumine binds IGF2BP3 and promotes its proteasome-dependent degradation, which reduces m6A enrichment on EED mRNA, accelerates EED decay, lowers H3K27me3, and derepresses IRF transcription, thereby restoring MHC-I expression and enhancing CD8+ T-cell killing. Crucially, koumine enhanced the efficacy of anti-PD-1 therapy in gastric cancer mouse models, suppressing tumor growth and fostering an immunologically active tumor microenvironment characterized by CD8+ T-cell infiltration and activation. This study identifies IGF2BP3 as an actionable target for improving antigen presentation and establishes koumine as a valuable chemical probe to dissect this pathway, with implications for immunotherapy sensitization beyond gastric cancer.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single-Cell Level in CTCs From HR+/HER2- Metastatic Breast Cancer. HR+/HER2-转移性乳腺癌ctc单细胞水平PI3K/AKT/PTEN通路改变的研究

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-25 DOI: 10.1111/cas.70508

Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino

{"title":"Elucidating PI3K/AKT/PTEN Pathway Alterations at Single-Cell Level in CTCs From HR+/HER2- Metastatic Breast Cancer.","authors":"Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino","doi":"10.1111/cas.70508","DOIUrl":"10.1111/cas.70508","url":null,"abstract":"Alterations in the PI3K signaling pathway are common in hormone receptor-positive (HR+)/HER2-negative metastatic breast cancer (MBC) and are associated with response to PI3K and AKT inhibitor-targeted therapies. When metastasis biopsy is unavailable for genetic testing, circulating tumor DNA (ctDNA) analysis is an alternative strategy for tumor genotyping, but it is less sensitive for gain and loss analysis. Here, we assess molecular alterations of the genes of this axis-PIK3CA, AKT1, and PTEN-in circulating tumor cells (CTCs) from patients with HR+/HER2- MBC. CTCs from blood were isolated as single cells with DEPArrayNxT. Libraries were prepared for copy number analysis (CNA) and investigation of PIK3CA, AKT1, and PTEN mutational status. A subset of viable CTCs underwent 3' RNA sequencing for transcriptomic profiling. CTCs of 4/5 MBC patients (80%) exhibited single nucleotide variants (SNVs), and heterogeneity was observed at inter- and intra-patient levels. CNA profiling of CTCs from 8 patients revealed amplifications and gains of chromosomal regions hosting PIK3CA, AKT1, and PTEN. Notably, one patient presented both 10q32.31 loss and a nonsense mutation of the remaining PTEN allele, suggesting PTEN loss of function, an event potentially missed by ctDNA analysis. Integrated transcriptomic analysis highlighted patient-specific enrichment of pathways related to metabolism and RNA processing. Conclusively, single-CTC analysis enables comprehensive characterization of the PI3K/AKT/PTEN pathway, revealing molecular heterogeneity and capturing events not detectable by tumor tissue or ctDNA. This approach may enhance molecular stratification and guide the use of targeted therapies in MBC, supporting its integration into future precision oncology frameworks.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling. 心理应激通过髓细胞信号传导促进肝癌模型肿瘤生长。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-25 DOI: 10.1111/cas.70517

Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi

{"title":"Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling.","authors":"Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi","doi":"10.1111/cas.70517","DOIUrl":"10.1111/cas.70517","url":null,"abstract":"Psychological stress has long been implicated in cancer progression, yet the underlying biological pathways remain incompletely understood. In particular, the influence of stress on myeloid cells remains poorly explored. Here, we demonstrate that restraint stress accelerates hepatocellular carcinoma (HCC) progression through coordinated regulation of macrophages and neutrophils. Across sexes and strains, stressed mice exhibited enhanced tumor growth accompanied by marked neutrophil infiltration and elevated expression of neutrophil-attracting chemokines. Integrative analyses combining single-cell transcriptomics and in vitro experiments identified macrophages as the dominant producers of these chemokines and revealed that β2-adrenergic receptor signaling drives Cxcl2 expression in response to stress-related catecholamines. In parallel, neutrophils themselves were reprogrammed toward an immunosuppressive phenotype under stress. This phenotypic shift was already evident in bone marrow neutrophils, where activation of the hypothalamic-pituitary-adrenal (HPA) axis led to corticosterone-driven, glucocorticoid receptor-dependent induction of an immunosuppressive gene. These findings define a coordinated neuroendocrine mechanism in which psychological stress remodels myeloid cell function through sympathetic and HPA axis signaling, thereby fostering an immunosuppressive tumor microenvironment that promotes HCC progression. While pharmacologic blockade of either axis may mitigate stress-driven tumor growth, our findings suggest that non-pharmacological stress-reduction strategies could represent a valuable complementary approach in managing HCC progression.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Life's Essential 8 Score With Incident Pancreatic Cancer: A Prospective Cohort Study in Shanghai, China. 生命基本8评分与胰腺癌发病率的关系：中国上海的一项前瞻性队列研究

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-24 DOI: 10.1111/cas.70512

Liping Yi, Xing Liu, Maryam Zaid, Kexin Zhang, Biying Wang, Yingqi Deng, Minhua Tang, Yonggen Jiang, Genming Zhao

{"title":"Association of Life's Essential 8 Score With Incident Pancreatic Cancer: A Prospective Cohort Study in Shanghai, China.","authors":"Liping Yi, Xing Liu, Maryam Zaid, Kexin Zhang, Biying Wang, Yingqi Deng, Minhua Tang, Yonggen Jiang, Genming Zhao","doi":"10.1111/cas.70512","DOIUrl":"10.1111/cas.70512","url":null,"abstract":"Life's Essential 8 (LE8) is a comprehensive metric of cardiovascular health (CVH). Higher LE8 scores have been associated with lower risks of chronic diseases, but evidence regarding pancreatic cancer (PC) in Chinese populations is scarce. We analyzed data from 60,556 cancer-free adults in the Shanghai Suburban Adult Cohort and Biobank. LE8 includes four health behaviors (diet, physical activity, nicotine exposure, sleep) and four health factors (BMI, blood lipids, blood glucose, blood pressure), measured by questionnaires, physical examinations, and biochemical tests. Total scores (0-100) were categorized as low (< 50), moderate (50-79), and high (≥ 80) CVH. Incident PC was identified through cancer registries, hospital systems, and death records. Associations were assessed using multivariable Cox models. Over a median 7.4-year follow-up, 200 participants (0.3%) developed PC. Compared with participants with low CVH, those with moderate CVH (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.46-0.92) and high CVH (HR = 0.39, 95% CI = 0.19-0.82) had lower risks of PC. Each one standard deviation increase in LE8 score was associated with an 18% lower risk of PC (HR = 0.82, 95% CI = 0.70-0.96), with a linear inverse relationship. The association was attenuated after excluding the nicotine exposure component. The estimated population attributable fraction for suboptimal CVH was 40.5%. Stronger associations appeared in men and participants aged ≥ 60; a significant interaction with sex was observed. Overall, better LE8-defined CVH was associated with reduced PC risk, and smoking-related exposure may have contributed importantly to the observed association.","PeriodicalId":48943,"journal":{"name":"Cancer Science","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's Reply: Neutrophil-Macrophage Interactions in Gastric Cancer. 嗜中性粒细胞-巨噬细胞在胃癌中的相互作用。

IF 4.3 2区医学

Cancer Science Pub Date : 2026-08-23 DOI: 10.1111/cas.70506

Keita H Nagaoka, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Takuya Nakatsuru, Ryo Kamata, Shunsuke A Sakai, Gaku Yamamoto, Tomoko Y Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Sai M Pulukuri, Yuko Ishii, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi

引用次数: 0