Diabetes-Metabolism Research and Reviews最新文献

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A New Quantitative Neuropad for Early Diagnosis of Diabetic Peripheral Neuropathy. 用于早期诊断糖尿病周围神经病变的新型定量神经垫。

IF 8 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2024-11-01 DOI: 10.1002/dmrr.70010

Zheng Yang, Subei Zhao, Yuhuan Lv, Linyu Xiang, Xiaoru Zhang, Zhengping Feng, Zhiping Liu, Rong Li

{"title":"A New Quantitative Neuropad for Early Diagnosis of Diabetic Peripheral Neuropathy.","authors":"Zheng Yang, Subei Zhao, Yuhuan Lv, Linyu Xiang, Xiaoru Zhang, Zhengping Feng, Zhiping Liu, Rong Li","doi":"10.1002/dmrr.70010","DOIUrl":"https://doi.org/10.1002/dmrr.70010","url":null,"abstract":"Aims: Diabetic peripheral neuropathy (DPN) often coexists with sudomotor dysfunction, resulting in an increased risk of diabetic foot. This study aimed to explore an efficient method for early diagnosis of DPN by establishing a quantitative Neuropad.Methods: We recruited 518 patients with type 2 diabetes. Neuropathy Symptoms Score (NSS) combined with Neuropathy Disability Score (NDS) was used to assess distal symmetrical peripheral neuropathy (DSPN). The area under the ROC curve (AUROC), sensitivity, and specificity were used to compare the diagnostic efficacy of quantitative Neuropad (the change rate of the chromatic aberration value per minute) and two types of visual Neuropad (visual Neuropad A: whether the time to complete colour change within 10 min, visual Neuropad B: the time to complete colour change) for DPN.Results: We did not observe very good diagnostic efficacy of Neuropad (visual Neuropad A and B: 0.59 and 0.64, quantitative Neuropad AUROC: 0.62-0.64) when using standard DSPN diagnostic criteria (NDS 6-12 or NDS 3-5 combined with NSS 5-9). When DPN was assessed by NSS + NDS ≥ 4, visual Neuropad B improved the specificity (AUROC 0.72, 67.00%, specificity 71.70%) by extending the detection time compared with visual Neuropad A (AUROC 0.62, sensitivity 81.80%, specificity 41.70%). Quantitative Neuropad significantly improved the diagnostic effect (AUROC 0.81, sensitivity 80.0%, specificity 76.3%) and reduced the detection time (4 min).Conclusions: This study provides a new quantitative Neuropad, which has great potential to be an extremely useful diagnostic tool for early screening of sudomotor dysfunction in the clinical practice.","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"40 8","pages":"e70010"},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of action of metformin with special reference to cardiovascular protection. 二甲双胍对心血管保护的作用机制。

IF 8 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2019-10-01 Epub Date: 2019-07-24 DOI: 10.1002/dmrr.3173

Alexey V Zilov, Sulaf Ibrahim Abdelaziz, Afaf AlShammary, Ali Al Zahrani, Ashraf Amir, Samir Helmy Assaad Khalil, Kerstin Brand, Nabil Elkafrawy, Ahmed A K Hassoun, Adel Jahed, Nadim Jarrah, Sanaa Mrabeti, Imran Paruk

{"title":"Mechanisms of action of metformin with special reference to cardiovascular protection.","authors":"Alexey V Zilov, Sulaf Ibrahim Abdelaziz, Afaf AlShammary, Ali Al Zahrani, Ashraf Amir, Samir Helmy Assaad Khalil, Kerstin Brand, Nabil Elkafrawy, Ahmed A K Hassoun, Adel Jahed, Nadim Jarrah, Sanaa Mrabeti, Imran Paruk","doi":"10.1002/dmrr.3173","DOIUrl":"10.1002/dmrr.3173","url":null,"abstract":"Management guidelines continue to identify metformin as initial pharmacologic antidiabetic therapy of choice for people with type 2 diabetes without contraindications, despite recent randomized trials that have demonstrated significant improvements in cardiovascular outcomes with newer classes of antidiabetic therapies. The purpose of this review is to summarize the current state of knowledge of metformin's therapeutic actions on blood glucose and cardiovascular clinical evidence and to consider the mechanisms that underlie them. The effects of metformin on glycaemia occur mainly in the liver, but metformin-stimulated glucose disposal by the gut has emerged as an increasingly import site of action of metformin. Additionally, metformin induces increased secretion of GLP-1 from intestinal L-cells. Clinical cardiovascular protection with metformin is supported by three randomized outcomes trials (in newly diagnosed and late stage insulin-treated type 2 diabetes patients) and a wealth of observational data. Initial evidence suggests that cotreatment with metformin may enhance the impact of newer incretin-based therapies on cardiovascular outcomes, an important observation as metformin can be combined with any other antidiabetic agent. Multiple potential mechanisms support the concept of cardiovascular protection with metformin beyond those provided by reduced blood glucose, including weight loss, improvements in haemostatic function, reduced inflammation, and oxidative stress, and inhibition of key steps in the process of atherosclerosis. Accordingly, metformin remains well placed to support improvements in cardiovascular outcomes, from diagnosis and throughout the course of type 2 diabetes, even in this new age of improved outcomes in type 2 diabetes.","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"35 7","pages":"e3173"},"PeriodicalIF":8.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/3a/DMRR-35-na.PMC6851752.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0