Diabetes-Metabolism Research and Reviews最新文献

Skin Autofluorescence as a Predictor of Bone Fragility in Type 1 Diabetes: A Critical Appraisal of the Evidence. 皮肤自身荧光作为1型糖尿病骨质脆性的预测因子：对证据的关键评估。

IF 6 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-10-01 DOI: 10.1002/dmrr.70099

DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang

{"title":"Skin Autofluorescence as a Predictor of Bone Fragility in Type 1 Diabetes: A Critical Appraisal of the Evidence.","authors":"DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang","doi":"10.1002/dmrr.70099","DOIUrl":"https://doi.org/10.1002/dmrr.70099","url":null,"abstract":"In their cross-sectional study, Brandt et al. propose skin autofluorescence (SAF) as a potential predictor of impaired bone quality in type one diabetes, a hypothesis of significant clinical interest. This letter provides a critical appraisal of this claim. While the biological rationale linking advanced glycation endproducts to bone matrix properties is sound, we argue that the study's cross-sectional design fundamentally limits its ability to establish predictive utility, as it can only demonstrate association, not causation or forecasting of future events. Furthermore, the modest improvement in the area under the curve lacks a demonstrated meaningful clinical impact, such as net reclassification improvement. The assumption that dermal SAF accurately reflects the skeletal advanced glycation endproduct pool remains unvalidated and may be confounded by systemic disease severity. We conclude that while the findings are hypothesis-generating, prospective longitudinal studies and direct tissue validation are imperative before SAF can be considered a validated clinical predictor.","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"41 7","pages":"e70099"},"PeriodicalIF":6.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Kidney Disease in China: Addressing the Burden With Innovative Strategies and Global Insights. 中国慢性肾脏疾病：以创新策略和全球视角解决负担。

IF 6 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-10-01 DOI: 10.1002/dmrr.70092

Xiaoqiang Ding

引用次数: 0

Exploring Insulin Resistance in Adults With Type 1 Diabetes: The Role of the Estimated Glucose Disposal Rate and the Triglyceride Glucose Index. 探索成人1型糖尿病患者的胰岛素抵抗：估计葡萄糖处置率和甘油三酯葡萄糖指数的作用

IF 6 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-10-01 DOI: 10.1002/dmrr.70100

Silvia Angelino, Antonietta Monda, Nicole Di Martino, Paola Caruso, Miriam Longo, Antonietta Maio, Mariluce Barrasso, Lorenzo Scappaticcio, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito, Maria Ida Maiorino

{"title":"Exploring Insulin Resistance in Adults With Type 1 Diabetes: The Role of the Estimated Glucose Disposal Rate and the Triglyceride Glucose Index.","authors":"Silvia Angelino, Antonietta Monda, Nicole Di Martino, Paola Caruso, Miriam Longo, Antonietta Maio, Mariluce Barrasso, Lorenzo Scappaticcio, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito, Maria Ida Maiorino","doi":"10.1002/dmrr.70100","DOIUrl":"https://doi.org/10.1002/dmrr.70100","url":null,"abstract":"Aims: People with type 1 diabetes (T1D) who exhibit insulin resistance present a high cardiovascular risk. Several markers, including the estimated Glucose Disposal Rate (eGDR) and Triglyceride-Glucose (TyG) index, have been developed for measuring insulin resistance. The debate on the most reliable surrogate estimator is still open. The aim was to assess the prevalence of insulin resistance by eGDR and TyG index in adults with T1D, describe the characteristics of the population according to insulin resistance, and investigate the association between these indices and glucose control.Materials and methods: This study involved adults with T1D of both sexes in stable insulin treatment for at least 6 months, whose data were collected at 1-year follow-up visit. Insulin resistance was based on eGDR < 8 and TyG index ≥ 4.68.Results: We included 687 adults with a median age of 29.0 years and diabetes duration of 18.0 years. Insulin resistance was found in 25.8% and 39.2% of the population based on the eGDR and TyG index, respectively. Compared with those without insulin resistance, insulin-resistant participants showed poorer glyco-metabolic parameters and required larger daily insulin dose; moreover, people with insulin resistance according to the TyG index needed higher daily insulin doses/kg. At logistic regression, we found significant association between glucose control (HbA1c ≤ 7%) and both eGDR (β = 1.143) and TyG index (β = -1.578).Conclusions: In adults with T1D, there was a significant prevalence of insulin resistance measured by the eGDR e TyG index, which was effective in identifying individuals who needed higher insulin doses/kg. Both indices correlated with glucose control.","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"41 7","pages":"e70100"},"PeriodicalIF":6.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withdrawal: Letter to the Editor - responses to Weisntein D, Simon M, Yehezkel E, Laron Z, Werner H. Insulin analogues display IGF-I-like mitogenic and antiactivity in cultured cancer cells. Weisntein D, Simon M, Yehezkel E, Laron Z, Werner H.胰岛素类似物在培养的癌细胞中显示igf - i样有丝分裂和抗活性。

IF 6 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-05-01 DOI: 10.1002/dmrr.2447

引用次数: 0

Withdrawal: Screening for people with glucose metabolism disorders within the framework of the DEMOJUAN project (DEMOnstration area for primary prevention of type 2 diabetes, JUAN Mina and Barranquilla, Colombia). 退出：在DEMOJUAN项目（2型糖尿病初级预防示范区，JUAN Mina和Barranquilla，哥伦比亚）框架内筛查糖代谢障碍患者。

IF 8 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-05-01 DOI: 10.1002/dmrr.2462

引用次数: 0

Withdrawal: Prevalence of type 2 diabetes in Argentina 1979-2012. 退出：1979-2012年阿根廷2型糖尿病患病率

IF 6 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-05-01 DOI: 10.1002/dmrr.2436

引用次数: 0

Withdrawal: Can we prevent beta cell apoptosis in type 2 diabetes? 停药：我们能预防2型糖尿病的β细胞凋亡吗？

IF 8 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-05-01 DOI: 10.1002/dmrr.2381

引用次数: 0

Withdrawal: Type 2 Diabetes Mellitus and Alzheimer's Disease: from physiopathology to treatment implications. 退出：2型糖尿病和阿尔茨海默病：从生理病理到治疗意义。

IF 6 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-05-01 DOI: 10.1002/dmrr.2442

引用次数: 0

Withdrawal: Do we need continuous glucose monitoring in type 2 diabetes? 停药：2型糖尿病患者是否需要持续血糖监测？

IF 8 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2025-05-01 DOI: 10.1002/dmrr.2450

引用次数: 0

A New Quantitative Neuropad for Early Diagnosis of Diabetic Peripheral Neuropathy. 用于早期诊断糖尿病周围神经病变的新型定量神经垫。

IF 8 2区医学

Diabetes-Metabolism Research and Reviews Pub Date : 2024-11-01 DOI: 10.1002/dmrr.70010

Zheng Yang, Subei Zhao, Yuhuan Lv, Linyu Xiang, Xiaoru Zhang, Zhengping Feng, Zhiping Liu, Rong Li

{"title":"A New Quantitative Neuropad for Early Diagnosis of Diabetic Peripheral Neuropathy.","authors":"Zheng Yang, Subei Zhao, Yuhuan Lv, Linyu Xiang, Xiaoru Zhang, Zhengping Feng, Zhiping Liu, Rong Li","doi":"10.1002/dmrr.70010","DOIUrl":"https://doi.org/10.1002/dmrr.70010","url":null,"abstract":"Aims: Diabetic peripheral neuropathy (DPN) often coexists with sudomotor dysfunction, resulting in an increased risk of diabetic foot. This study aimed to explore an efficient method for early diagnosis of DPN by establishing a quantitative Neuropad.Methods: We recruited 518 patients with type 2 diabetes. Neuropathy Symptoms Score (NSS) combined with Neuropathy Disability Score (NDS) was used to assess distal symmetrical peripheral neuropathy (DSPN). The area under the ROC curve (AUROC), sensitivity, and specificity were used to compare the diagnostic efficacy of quantitative Neuropad (the change rate of the chromatic aberration value per minute) and two types of visual Neuropad (visual Neuropad A: whether the time to complete colour change within 10 min, visual Neuropad B: the time to complete colour change) for DPN.Results: We did not observe very good diagnostic efficacy of Neuropad (visual Neuropad A and B: 0.59 and 0.64, quantitative Neuropad AUROC: 0.62-0.64) when using standard DSPN diagnostic criteria (NDS 6-12 or NDS 3-5 combined with NSS 5-9). When DPN was assessed by NSS + NDS ≥ 4, visual Neuropad B improved the specificity (AUROC 0.72, 67.00%, specificity 71.70%) by extending the detection time compared with visual Neuropad A (AUROC 0.62, sensitivity 81.80%, specificity 41.70%). Quantitative Neuropad significantly improved the diagnostic effect (AUROC 0.81, sensitivity 80.0%, specificity 76.3%) and reduced the detection time (4 min).Conclusions: This study provides a new quantitative Neuropad, which has great potential to be an extremely useful diagnostic tool for early screening of sudomotor dysfunction in the clinical practice.","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"40 8","pages":"e70010"},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0