Diabetes-Metabolism Research and Reviews最新文献

{"title":"Disentangling the Multifactorial Influences on Diabetes Risk Among Rural Communities: Food Environment, Diet Quality, and Dietary Chemical Exposures.","authors":"David C Lee, Haley L Motola, Jessie Moore, Tammy Flores, Crystal So, Haeseung Yi, Vittorio Albergamo, Leonardo Transande, Brian Elbel, Lorna E Thorpe","doi":"10.1002/dmrr.70177","DOIUrl":"https://doi.org/10.1002/dmrr.70177","url":null,"abstract":"<p><strong>Aims: </strong>Rural communities experience a higher prevalence of type 2 diabetes and diabetes-related mortality than urban populations. This study sought to disaggregate the influences of demographic and socioeconomic factors, food environment, diet quality, and dietary chemical exposures on diabetes risk in rural areas.</p><p><strong>Materials and methods: </strong>We enrolled participants from rural Sullivan County in an observational cohort study involving surveys and biospecimen collection measuring bisphenols and phthalates. We measured these endocrine disrupting chemicals found in food packaging, as rural residents generally consume canned foods and other shelf-stable foods more frequently than their urban counterparts. We used LASSO regression to compare the relative influence of these factors had on rural diabetes risk.</p><p><strong>Results: </strong>Based on values for LASSO regression coefficients among 276 participants, the strongest risk factors for diagnosed diabetes included: older age (+0.486), lower household income (+0.172), Hispanic ethnicity (+0.124), red meat intake (+0.093), proportion of fast food restaurants among nearby restaurants (+0.071), and two phthalates (+0.149 and + 0.107). Among study participants without a history of diabetes, high HbA1c levels were associated with older age (+0.106), being non-Hispanic Black (+0.064), more trans-fat and red meat intake (+0.044 and +0.028), higher BMI (+0.014), higher levels of total bisphenols (+0.005), and higher levels of high-molecular weight phthalates (+0.002).</p><p><strong>Conclusions: </strong>Demographic and socioeconomic factors were the strongest predictors of rural diabetes risk; however, diet quality, food environment, and dietary chemical exposures also each played a key role. Our study identified modifiable risk factors, which could help reduce the burden of rural diabetes.</p>","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"42 4","pages":"e70177"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality and Characteristics of Short Spanish-Language Videos on Social Media About Type 2 Diabetes Mellitus.","authors":"Anderson N Soriano-Moreno, Carlos Quispe-Vicuña, Milagros L Garcia-Cordova, Ruth Mery Valera-Palli, Sandy Ester Saldaña-Cabanillas","doi":"10.1002/dmrr.70178","DOIUrl":"https://doi.org/10.1002/dmrr.70178","url":null,"abstract":"<p><strong>Background: </strong>Social media has become a common source of educational information on type 2 diabetes. However, evidence regarding the quality of this content remains limited. This study evaluated the quality of short Spanish-language videos about type 2 diabetes published on Facebook, Instagram, TikTok, and YouTube.</p><p><strong>Methods: </strong>A cross-sectional study analysed 400 short videos, including the top-ranked videos identified per platform (n = 100 each), collected between March 4 and 25, 2026. Spanish-language short-form videos (≤ 10 min) on type 2 diabetes intended for a general audience were included, while promotional or humourous content was excluded. Informational quality was assessed using the Journal of the American Medical Association (JAMA) benchmark criteria and the Global Quality Score (GQS).</p><p><strong>Results: </strong>Overall, quality was low, with a mean GQS score of 2.5 ± 0.82 (on a 5-point scale) and low adherence to JAMA criteria, including authorship (35.5%), attribution (5.8%), and disclosure (1.0%). In multivariable analysis, videos on YouTube (β: 0.6; 95% CI: 0.3-0.8) and Instagram (β: 0.3; 95% CI: 0.1-0.5) had higher GQS scores compared with TikTok. Videos featuring a health professional were also associated with higher GQS scores (β: 0.4; 95% CI: 0.2-0.6). Compared with videos shorter than 30 s, videos lasting 31-60 s (β: 0.3; 95% CI: 0.0-0.6), 61-120 s (β: 0.5; 95% CI: 0.2-0.8), and more than 120 s (β: 0.7; 95% CI: 0.4-1.0) had higher GQS scores.</p><p><strong>Conclusion: </strong>Spanish-language type 2 diabetes-related videos on social media generally showed low quality. Higher quality was associated with content featuring healthcare professionals, longer video duration, and platforms such as YouTube and Instagram.</p>","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"42 4","pages":"e70178"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensated But Failing: Early β-Cell Dysfunction Under Normoglycemia in Children and Adolescents With Overweight and Obesity.","authors":"Paulina Correa-Burrows, Estela Blanco, Raquel Burrows","doi":"10.1002/dmrr.70172","DOIUrl":"https://doi.org/10.1002/dmrr.70172","url":null,"abstract":"<p><strong>Background: </strong>The global rise of obesity has accelerated the onset of type-2 diabetes mellitus (T2DM) also among youth. Early detection of impaired β-cell function in at-risk populations is crucial for prevention; however, reference standards for children and adolescents remain scarce. We aimed to establish population-based percentile distributions specific to developmental stage and weight status for multiple markers of β-cell function in Chilean youth, thereby addressing this critical gap.</p><p><strong>Methods: </strong>Cross-sectional study in 988 children and adolescents aged 6-17 years. Anthropometric measurements included weight, height, and waist circumference; weight status was classified using WHO 2007 standards. Participants were stratified into three developmental groups: Tanner 1-2 (G1), Tanner 3-5 (G2), and adolescents ≥ 16 years (G3). Fasting glucose and insulin were measured; insulin sensitivity and β-cell function were estimated using HOMA. Disposition index (DI) was calculated.</p><p><strong>Results: </strong>G2 participants exhibited higher insulin, HOMA-IR, and HOMA-β levels, alongside lower HOMA-S levels compared to G1 and G3. Across all developmental groups, β-cell function varied by weight status: normal-weight individuals displayed more favourable insulin profiles than those with overweight or obesity. DI declined significantly with excess weight in G3, although values remained below 1.0 across groups. Fasting glucose was consistently within the normal range, independent of weight status.</p><p><strong>Conclusion: </strong>Our findings suggest that differences in β-cell function may be present even in the context of normal fasting glucose, indicating that glycaemia alone may not fully capture early variations in glucose-insulin dynamics. Since pubertal stage and adiposity significantly influenced these results, incorporating development- and weight-specific considerations may improve the interpretation of metabolic markers during growth. These findings support the need for more nuanced approaches to characterise metabolic variability in youth.</p>","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"42 4","pages":"e70172"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Misinterpretation of Nonsignificant Results in Diabetes Randomised Clinical Trials.","authors":"Amin Sharifan, Gregg C Fonarow","doi":"10.1002/dmrr.70179","DOIUrl":"https://doi.org/10.1002/dmrr.70179","url":null,"abstract":"","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"42 4","pages":"e70179"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications.","authors":"Ye Hu, Xinmiao Zhang, Changwei Yang, Xiaohong Wu, Xiao Ye, Jicheng Yu, Yunbei Yang","doi":"10.1002/dmrr.70171","DOIUrl":"https://doi.org/10.1002/dmrr.70171","url":null,"abstract":"<p><p>Metformin is derived from the plant Galega officinalis with the blood-glucose-lowering properties. Although its early development was hindered by the toxicity issues associated with other guanidine derivatives and the rise of insulin therapies, it ultimately established its position as a first-line oral hypoglycemic agent for addressing insulin resistance and managing hyperglycemia through extensive clinical validation. With a nearly 70-year history in diabetes treatment, the mechanisms by which metformin modulates blood glucose have been widely studied and refined. Recent investigations into combination therapies, fixed-dose formulations, and novel applications underscores a broader therapeutic potential beyond glycemic control. This paper aims to review the development trajectory of metformin, consolidate the latest evidence for its clinical benefits, and critically appraise its future directions and constraints.</p>","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"42 4","pages":"e70171"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous Recovery of Fasting C-Peptide Decreases Progression of Sudomotor Small-Fibre Dysfunction in Adults With Diabetes: A Real-World Cohort Study.","authors":"Qingyun Cai, Ting Xie, Hongjian Gong, Wenjie Zhang, Lixin Guo, Qi Pan","doi":"10.1002/dmrr.70173","DOIUrl":"https://doi.org/10.1002/dmrr.70173","url":null,"abstract":"<p><strong>Aims: </strong>To determine whether recovery of fasting C-peptide (ΔFCP) reduces deterioration in sudomotor small-fibre function, whether a threshold exists, and whether associations are complication-specific.</p><p><strong>Methods: </strong>Retrospective real-world cohort of 288 hospitalised adults with diabetes with repeated fasting C-peptide and Sudoscan electrochemical skin conductance (ESC). Deterioration in sudomotor small-fibre function was defined as worsening foot ESC. Large-fibre neuropathy (LFN) and diabetic kidney disease (DKD) progression were assessed by nerve conduction and kidney outcomes. Cox models, restricted cubic splines, maximally selected rank statistics, and subgroup/landmark/sensitivity analyses were performed.</p><p><strong>Results: </strong>Over a median 2.2 years, higher ΔFCP was independently associated with lower risk of deterioration in sudomotor small-fibre function, but not with LFN or DKD progression. Highest versus lowest ΔFCP tertile: adjusted HR 0.31 (95% CI 0.14-0.69; p < 0.001). An optimal ΔFCP cutoff of 126.8 pmol/L was identified; ΔFCP ≥ 126.8 pmol/L was associated with a 66% lower risk of sudomotor deterioration (HR 0.34, 95% CI 0.17-0.69; p < 0.001), remaining robust in landmark and sensitivity analyses. Baseline C-peptide mediated little of the association.</p><p><strong>Conclusions: </strong>Endogenous fasting C-peptide recovery is linked to a clinically meaningful, threshold-dependent reduction in the progression of sudomotor small-fibre dysfunction, supporting β-cell preservation/recovery as targets in early diabetic neuropathy.</p>","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"42 4","pages":"e70173"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawal: Letter to the Editor - responses to Weisntein D, Simon M, Yehezkel E, Laron Z, Werner H. Insulin analogues display IGF-I-like mitogenic and antiactivity in cultured cancer cells.","authors":"","doi":"10.1002/dmrr.2447","DOIUrl":"10.1002/dmrr.2447","url":null,"abstract":"","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"41 4","pages":"e2447"},"PeriodicalIF":6.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawal: Screening for people with glucose metabolism disorders within the framework of the DEMOJUAN project (DEMOnstration area for primary prevention of type 2 diabetes, JUAN Mina and Barranquilla, Colombia).","authors":"","doi":"10.1002/dmrr.2462","DOIUrl":"10.1002/dmrr.2462","url":null,"abstract":"","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"41 4","pages":"e2462"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawal: Prevalence of type 2 diabetes in Argentina 1979-2012.","authors":"","doi":"10.1002/dmrr.2436","DOIUrl":"10.1002/dmrr.2436","url":null,"abstract":"","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"41 4","pages":"e2436"},"PeriodicalIF":6.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawal: Can we prevent beta cell apoptosis in type 2 diabetes?","authors":"","doi":"10.1002/dmrr.2381","DOIUrl":"10.1002/dmrr.2381","url":null,"abstract":"","PeriodicalId":48934,"journal":{"name":"Diabetes-Metabolism Research and Reviews","volume":"41 4","pages":"e2381"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}