ad-Dawaa' Journal of Pharmaceutical Sciences最新文献

Formulation and Antibacterial Activity of Porang (Amorphophallus muelleri Blume) Extract Gel Against Propionibacterium acne 茯苓提取物凝胶对痤疮丙酸杆菌的抑菌活性研究

ad-Dawaa' Journal of Pharmaceutical Sciences Pub Date : 2023-07-31 DOI: 10.24252/djps.v6i1.38744

Nurshalati Tahar, Dwi Wahyuni, Rabiatul Adawiyah, None Khaerani, Munifah Wahyuddin

引用次数: 0

Antibacterial Activity of Jackfruit Leaf (Artocarpus Heterophyllus LMK.) Ethanol Extract Gel on Propionibacterium acnes 菠萝蜜叶的抗菌活性研究乙醇提取物凝胶对痤疮丙酸杆菌的作用

ad-Dawaa' Journal of Pharmaceutical Sciences Pub Date : 2023-07-31 DOI: 10.24252/djps.v6i1.37608

Fitrya Fitrya, Elsa Fitria Apriani, Adik Ahmadi, Dina Permata Wijaya, Khazanah Nurain

{"title":"Antibacterial Activity of Jackfruit Leaf (Artocarpus Heterophyllus LMK.) Ethanol Extract Gel on Propionibacterium acnes","authors":"Fitrya Fitrya, Elsa Fitria Apriani, Adik Ahmadi, Dina Permata Wijaya, Khazanah Nurain","doi":"10.24252/djps.v6i1.37608","DOIUrl":"https://doi.org/10.24252/djps.v6i1.37608","url":null,"abstract":"Introduction: Artocarpus heterophyllus LMK. leaves contain flavonoids, tannins, and saponins, which have the potential to be antibacterial. Aims: This study aims to test the antibacterial activity of A. heterophyllus leaves ethanol extract, which is formulated in a gel preparation. Methods: Antibacterial testing was done on the acne-causing bacteria Propionibacterium acnes. The gel formula is designed with an extract concentration of 5, 10, or 15% with Carbopol 940 and HPMC as the bases. The antibacterial activity test was carried out using the well diffusion method. Result: The results of the study showed that the concentration of the extract affected pH, adhesive power, removability, and viscosity. Antibacterial activity tests showed that the gel of A. heterophyllus extract could inhibit Propionibacterium acnes bacteria. The higher the concentration of the extract, the greater the antibacterial activity. Conclusion: It can be concluded that the gel with an extract concentration of 15% gave the strongest antibacterial activity with an inhibition zone of 10.9 ± 1.18 mm.","PeriodicalId":488193,"journal":{"name":"ad-Dawaa' Journal of Pharmaceutical Sciences","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Activity Test of Roll on Deodorant Extract Ethanol Tamarind Seed Coat 罗望子种皮除臭液乙醇的抑菌活性试验

ad-Dawaa' Journal of Pharmaceutical Sciences Pub Date : 2023-07-31 DOI: 10.24252/djps.v6i1.37568

Abdul Rahim Rahim, None Salmiah, Ersi Arviana Ihsan

{"title":"Antibacterial Activity Test of Roll on Deodorant Extract Ethanol Tamarind Seed Coat","authors":"Abdul Rahim Rahim, None Salmiah, Ersi Arviana Ihsan","doi":"10.24252/djps.v6i1.37568","DOIUrl":"https://doi.org/10.24252/djps.v6i1.37568","url":null,"abstract":"Introduction: Armpit odor is one of the problems caused by bacteria, one of which is Staphylococcus aureus. The rind of the tamarind seed contains tannins and flavonoids that function as antibacterial. Aims: The purpose of this study was to formulate the ethanolic extract of tamarind seed coat into roll-on deodorant preparations and to determine the zone of inhibition from variations in the concentration of the extract. Methods: The method used is the well diffusion method and the data obtained are then analyzed using Statistical Product and Service solution (SPSS). The level of confidence used is 95% to see the significance of each evaluation of the preparation. Result: The results showed that the roll on deodorant preparation of ethanol extract of tamarind seed coat did not meet the requirements for good dispersibility, adhesion and viscosity for topical preparations in general and emulsion preparations. The pH of the preparation met the axillary skin pH he standard for topical preparations. The roll-on deodorant preparation of ethanol extract of tamarind seed cultivars was effective in inhibiting the growth of Staphylococcus aureus bacteria. Conclusion: The results of inhibition zone 3 formulations containing extracts were in the strong category and the value increased with increasing concentration of tamarind seed coat extract in the deodorant preparation.","PeriodicalId":488193,"journal":{"name":"ad-Dawaa' Journal of Pharmaceutical Sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Body Weight Profile and Toxic Symptoms of White Rats on Giving Ethanol Fraction of Rambutan Peels (Nephelium lappaceum L) 红毛丹皮乙醇提取物对大鼠体重及中毒症状的影响

ad-Dawaa' Journal of Pharmaceutical Sciences Pub Date : 2023-07-31 DOI: 10.24252/djps.v6i1.37708

Anisa Pebiansyah, Lilis Tuslinah, Ade Yeni Aprilia

{"title":"Analysis of Body Weight Profile and Toxic Symptoms of White Rats on Giving Ethanol Fraction of Rambutan Peels (Nephelium lappaceum L)","authors":"Anisa Pebiansyah, Lilis Tuslinah, Ade Yeni Aprilia","doi":"10.24252/djps.v6i1.37708","DOIUrl":"https://doi.org/10.24252/djps.v6i1.37708","url":null,"abstract":"Introdiction: Rambutan peel (Nephelium lappaceum L) contains antioxidant compounds like flavonoids such as anthocyanins. The high antioxidant activity causes the high utilization of rambutan peel for treatment, but its side effects on the body are unknown. Aims: This study aimed to analyze the effect of giving rambutan rind ethanol fraction on body weight and toxic symptoms in white rats. Methods: The test was carried out using the OECD 425 method in which there were three treatment groups, each consisting of 5 test animals that were given the preparation orally. Treatment 1 was only given 1% CMC Na for 14 days; treatment 2 was given the ethanol fraction of rambutan peel 400 mg/200 g BW which was observed every 30 minutes for 4 hours, then up to 48 hours, then every day for up to 14 days. If there is none, it is continued with treatment 3, which is given the ethanol fraction of rambutan peel 1000 mg/200 g BW for 14 days. Symptoms of acute animal toxicity were observed for 14 days in that treatment. Result: The results showed that the ethanol fraction of rambutan peel doses of 400 mg/200 g BW and 1000 mg/200 g BW had a significant effect (p=0.017) in increasing the body weight profile of white rats, and there were no signs of acute toxicity in each treatment group. Conclusion: The dose of the ethanol fraction of rambutan peel 400 mg/200 g BW is the best, with an increased body weight of 25.17%.","PeriodicalId":488193,"journal":{"name":"ad-Dawaa' Journal of Pharmaceutical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Activity of Temu Blenyeh (Curcuma purpurascens Blume) Ethanol Extract Against on Streptococcus mutans and Candida albicans 姜黄醇提物对变形链球菌和白色念珠菌的抑菌活性

ad-Dawaa' Journal of Pharmaceutical Sciences Pub Date : 2023-07-30 DOI: 10.24252/djps.v6i1.37703

Oktariani Pramiastuti Okta, Ratna Tika Nikhmatul Laili

{"title":"Antimicrobial Activity of Temu Blenyeh (Curcuma purpurascens Blume) Ethanol Extract Against on Streptococcus mutans and Candida albicans","authors":"Oktariani Pramiastuti Okta, Ratna Tika Nikhmatul Laili","doi":"10.24252/djps.v6i1.37703","DOIUrl":"https://doi.org/10.24252/djps.v6i1.37703","url":null,"abstract":"Introduction: Temu blenyeh (Curcuma purpurascens Blume) is a species of Curcuma belonging to the Zingiberaceae family. This plant contains secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins, tannins, and polyphenols, which function as antimicrobials. Aims: The aims of this study was to determine the antimicrobial activity of the ethanol extract of intersection blenyeh against Streptococcus mutans and Candida albicans. Methods: The extraction process was carried out by maceration, and the antimicrobial activity test was carried out using paper disc diffusion. The negative control used in this study was 5% DMSO, while the positive control was 0.2% Chlorhexidine. Result: The results of phytochemical screening using the TLC method showed that the ethanol extract of intersection blenyeh contained flavonoids, alkaloids, terpenoids, saponins, tannins, and polyphenols. The results of the antimicrobial activity test of the ethanol extract of the temu blenyeh at concentrations of 30; 40; 50; 60; and 70% against Streptococcus mutans produced an inhibition zone belonging to the medium category with an average inhibition zone value of 6.75; 7.00; 7.08; 7.16; and 8.26 mm, while Candida albicans produced an inhibition zone that belonged to the very weak category with an average inhibition zone value of 2.75; 3.16; 3.33; 3.60; and 3.67 mm. Conclusion: The conclusion of this research is that the ethanol extract of intersection blenyeh has antimicrobial activity against Streptococcus mutans and Candida albicans.","PeriodicalId":488193,"journal":{"name":"ad-Dawaa' Journal of Pharmaceutical Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docking Molecular Study, Pharmacokinetics Profile and Toxicity Prediction of Basil Plant (Ocimum basillicum) Compounds as Isocitrates Dehydrogenase Inhibitor 罗勒植物异柠檬酸脱氢酶抑制剂对接分子研究、药动学特征及毒性预测

ad-Dawaa' Journal of Pharmaceutical Sciences Pub Date : 2023-05-31 DOI: 10.24252/djps.v5i2.37548

Fitril Imani, None Yusnita Rifai, None Herlina Rante, None Ansari Masri, None Andri Anugrah Pratama, None Musabbiha

{"title":"Docking Molecular Study, Pharmacokinetics Profile and Toxicity Prediction of Basil Plant (Ocimum basillicum) Compounds as Isocitrates Dehydrogenase Inhibitor","authors":"Fitril Imani, None Yusnita Rifai, None Herlina Rante, None Ansari Masri, None Andri Anugrah Pratama, None Musabbiha","doi":"10.24252/djps.v5i2.37548","DOIUrl":"https://doi.org/10.24252/djps.v5i2.37548","url":null,"abstract":"This study aims to predict the compounds from Ocimum basillicum that have potential as glioma inhibitors by inhibiting the enzyme isocitrate dehydrogenase (IDH). Forty-two compounds from Ocimum basillicum were carried out by molecular docking to the IDH receptor using the AutodockTools 1.5.7 program and continued prediction of pharmacokinetic profile and toxicity using ADMETab 2.0 and Toxtree. The validation of the molecular docking method showed an RMSD value of 1.8509 A. As a result of the research, we discovered several compounds had the best interactions in our investigation. Those compounds were Apigenin, Catechin, Chloronergic Acid, Ellagic Acid, Quercetin, Rutin, Eriodictyol, and Chicoric Acid, with binding affinity values of -7.1, -6.7, -7.1, -7.1, -7.1, -8.5, -7.2, and -6.5, respectively. Several compounds are predicted to have the potential to be developed as glioma inhibitors. Furthermore, the ADMET's predictions show that these potential compounds still require improvement in pharmacokinetics and toxicity. However, further laboratory investigations like in vitro and in vivo assays need to be conducted.","PeriodicalId":488193,"journal":{"name":"ad-Dawaa' Journal of Pharmaceutical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0