International Journal of Research in Orthopaedics最新文献

Efficacy and safety of tablet Ligashot in patients with ligament injury of knee and shoulder 利加舒片对膝关节和肩关节韧带损伤患者的疗效和安全性

International Journal of Research in Orthopaedics Pub Date : 2024-08-09 DOI: 10.18203/issn.2455-4510.intjresorthop20242273

Bijoy Deb, Bhuvanesh Gobaloussamy, Sakthibalan Murugesan, Gayathri Sivakumar

{"title":"Efficacy and safety of tablet Ligashot in patients with ligament injury of knee and shoulder","authors":"Bijoy Deb, Bhuvanesh Gobaloussamy, Sakthibalan Murugesan, Gayathri Sivakumar","doi":"10.18203/issn.2455-4510.intjresorthop20242273","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20242273","url":null,"abstract":"Background: Ligament injuries of knee and shoulder disrupts joint homeostasis and leads to an imbalance between joint mobility and stability. Many drugs are available in the market for treating ligament injury grade 1 and 2 along with standard of care but there is still need for drugs with least adverse effects. So, in this study, an attempt has been done with tablet Ligashot, a nutraceutical for treating grade 1 and 2 ligament injury of knee and shoulder.\u0000Methods: This is an outcome, quasi-experimental study where patients with ligament injury of knee and shoulder were given tablet Ligashot daily for 3 months. A total of 30 male and female patients were included in the study. Changes from baseline to 12 weeks in pain intensity measured by pain visual analogue scale (VAS) and inflammatory markers (ESR, Hs CRP), MRI changes, time to return to pre-injury level of activity, patient reported physical function and quality of life (QoL) were assessed.\u0000Results: There was a statistically significant improvement after 12 weeks of treatment compared to baseline in VAS pain scale, time to return to pre-injury level of activity, patient reported physical function and in QoL questionnaire. There was also a statistically significant reduction in inflammatory markers-ESR and Hs-CRP (p<0.001).\u0000Conclusions: Ligashot tablet has proved to be safe and effective in the management of ligament injury of knee, shoulder joint by reducing inflammation, pain. It also improves visco-elasticity and participant's functional capacity without causing any major side effects.","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":"42 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of efficacy and safety of Collashot C2 plus capsule in osteoarthritis patients 评估骨关节炎患者服用 Collashot C2 plus 胶囊的疗效和安全性

International Journal of Research in Orthopaedics Pub Date : 2024-07-12 DOI: 10.18203/issn.2455-4510.intjresorthop20241962

Bijoy Deb, Bhuvanesh Gobaloussamy, Sakthibalan Murugesan, Gayathri Sivakumar

{"title":"Evaluation of efficacy and safety of Collashot C2 plus capsule in osteoarthritis patients","authors":"Bijoy Deb, Bhuvanesh Gobaloussamy, Sakthibalan Murugesan, Gayathri Sivakumar","doi":"10.18203/issn.2455-4510.intjresorthop20241962","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20241962","url":null,"abstract":"Background: Osteoarthritis (OA), the most prevalent joint disease, is marked by chronic joint pain and debilitating symptoms. Many drugs are available in the market for treating osteo arthritis symptoms but there is still need for drugs with least adverse effects. So, in this study, an attempt has been done with Collashot C2 plus capsule, a nutraceutical for treating OA symptoms.\u0000Methods: This is an outcome, quasi-experimental study where patients with OA were included. Patients were given capsule Collashot C2 plus daily for 3 months. A total of 30 male and female patients were included in the study. Changes from baseline to 12 weeks in knee pain intensity measured by pain visual analogue scale (VAS) and in Western Ontario and McMaster universities OA index (WOMAC) pain subscale, laboratory parameters, participant's global assessment of improvement of OA were assessed. Adverse drug reactions were also observed during the study period.\u0000Results: There was a statistically significant improvement in the VAS pain scale, WOMAC pain score and in participant's global assessment of improvement of OA at week 4, week 8, and week 12 compared to baseline (p<0.001) was observed.\u0000Conclusions: Collashot C2 plus capsule has proved to be very safe and effective in the management of OA Participants by reducing inflammation, providing adequate pain relief without causing any major side effects.","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":"98 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141652744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of action of native collagen type II and Aflapin® on the pathophysiology of osteoarthritis and their evidences 天然 II 型胶原蛋白和 Aflapin® 对骨关节炎病理生理学的作用机制及其证据

International Journal of Research in Orthopaedics Pub Date : 2024-07-06 DOI: 10.18203/issn.2455-4510.intjresorthop20241946

Rakesh Verma, Rohit Nath, Rajesh K. Dhadiwal, G. V. Daftary, Mital A. Jolapara, Raj A. Shah, N. N. Patil

{"title":"Mechanisms of action of native collagen type II and Aflapin® on the pathophysiology of osteoarthritis and their evidences","authors":"Rakesh Verma, Rohit Nath, Rajesh K. Dhadiwal, G. V. Daftary, Mital A. Jolapara, Raj A. Shah, N. N. Patil","doi":"10.18203/issn.2455-4510.intjresorthop20241946","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20241946","url":null,"abstract":"Osteoarthritis (OA) is a degenerative and chronic inflammatory disease that affects the entire joint tissue such as articular cartilage, synovial membrane, subchondral bone, and ligaments. Imbalance between anabolism and catabolism lead to degradation of articular cartilage which may further initiate inflammatory cascades. There is an interplay of mechanical and immune-mediated injuries that lead to cartilage destruction and inflammation in OA. The mainstay of OA treatment involves drugs like paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) which provide symptomatic relief in many cases; but are unable to inhibit disease progression. Also, long-term use of these drugs, is associated with major safety concerns. Native collagen type II (NC-II) and Aflapin, especially when used in combination, can slow down the disease progression in OA and serve as a safer and effective treatment option for OA. NC-II is non-hydrolyzed collagen having intact triple helix structure with active epitopes and antigenicity. Aflapin is a novel synergistic composition of Boswellia serrata gum resin having higher composition of 3-O-acetyl-11-keto-betaboswellic acid (AKBA). Various experimental studies have demonstrated the mechanisms by which both these agents exert their benefit in OA. Further, multiple clinical studies have demonstrated the efficacy and safety of NC-II and Aflapin, when used individually or as a combination. This is a narrative review of the pathophysiology of OA, current treatment modalities, and non-clinical and clinical evidence of the beneficial effects of NC-II and Aflapin in the management of OA.","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the efficacy of rehabilitation outcomes of the femoral neck system in treating femoral neck fractures: a two-year prospective study 评估股骨颈系统治疗股骨颈骨折的康复疗效：一项为期两年的前瞻性研究

International Journal of Research in Orthopaedics Pub Date : 2024-07-06 DOI: 10.18203/issn.2455-4510.intjresorthop20241945

Sachin Kale, Bhushan Patil, Abhilash Srivastava, Nrupam Mehta, Varmit Shah, A. Chalak, P. Bhor, Gaurav Kanade, Garvit Khatod, Jayesh Patnaik

{"title":"Evaluating the efficacy of rehabilitation outcomes of the femoral neck system in treating femoral neck fractures: a two-year prospective study","authors":"Sachin Kale, Bhushan Patil, Abhilash Srivastava, Nrupam Mehta, Varmit Shah, A. Chalak, P. Bhor, Gaurav Kanade, Garvit Khatod, Jayesh Patnaik","doi":"10.18203/issn.2455-4510.intjresorthop20241945","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20241945","url":null,"abstract":"\u0000\u0000\u0000\u0000Background: Femoral neck fractures are prevalent among the elderly, and the femoral neck system (FNS), introduced in 2017, provides a minimally invasive treatment option with a dynamic bolt feature that enhances stability and facilitates early mobilization.\u0000Methods: This study involved 30 patients with femoral neck fractures treated with FNS at Dr. D. Y. Patil Medical College and Hospital from January 2021 to February 2023. The patients, aged 45-85 years, adhered to a structured rehabilitation protocol. Clinical outcomes were assessed using the Harris hip score (HHS) over 2-year follow-up period.\u0000Results: The cohort consisted of 30 patients (mean age: 65±10 years; 70% male). Fractures were classified as Pauwels I (30%), Pauwels II (40%), and Pauwels III (30%). At the final follow-up, 27 patients (90%) achieved union. The HHS improved significantly from a mean of 35±10 preoperatively to 85±15 postoperatively. Complications included one implant failure, one instance of limb shortening, and one case of avascular necrosis.\u0000Conclusions: The FNS is a safe and effective treatment for femoral neck fractures, promoting early weight-bearing and joint mobilization, leading to improved functional outcomes and reduced complications.\u0000\u0000\u0000\u0000","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":" 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional outcome of diaphyseal fractures of forearm in children treated with titanium elastic nailing system 用钛弹性钉系统治疗儿童前臂骨骺骨折的功能性结果

International Journal of Research in Orthopaedics Pub Date : 2024-04-06 DOI: 10.18203/issn.2455-4510.intjresorthop20240934

Kazi Shahadat Hossain, Abdullah Al Rafi, Qaisur Rabbi, M. S. Mia, M. A. R. Kawchar

{"title":"Functional outcome of diaphyseal fractures of forearm in children treated with titanium elastic nailing system","authors":"Kazi Shahadat Hossain, Abdullah Al Rafi, Qaisur Rabbi, M. S. Mia, M. A. R. Kawchar","doi":"10.18203/issn.2455-4510.intjresorthop20240934","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20240934","url":null,"abstract":"Background: Forearm fractures are common injuries in children, with diaphyseal fractures of the forearm being among the most frequent injuries treated in the pediatric population. This study aimed to assess the functional outcome of diaphyseal fractures of the forearm in children treated with the titanium elastic nailing system.\u0000Methods: This prospective observational study was conducted at the Department of Orthopaedics, Mainamoti Medical College, Cumilla, Bangladesh from January 2020 to December 2022. The study included 67 patients aged 6-15 with diaphyseal forearm fractures treated with the titanium elastic nailing system, selected through purposive sampling. MS Office tools were used for data analysis.\u0000Results: According to the functional outcome criteria described by Price et al., it was observed that in the highest number of patients (86.56%), the functional outcome was excellent, followed by good, fair, and poor outcomes found in 8.96%, 2.99%, and 1.49% of the cases, respectively. As the postoperative complications, the delayed union was found among 4%, and skin infection was found among 3% of cases.\u0000Conclusions: Considering the excellent outcomes and lower complication rate, the titanium elastic nailing system may be considered a very effective and safe treatment method for the management of diaphyseal fractures of the forearm in children.","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":"33 126","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in stem cell therapy for articular cartilage lesions: clinical evidence and future directions: a systematic review 干细胞治疗关节软骨损伤的进展：临床证据与未来方向：系统综述

International Journal of Research in Orthopaedics Pub Date : 2024-04-06 DOI: 10.18203/issn.2455-4510.intjresorthop20240935

Kevin Steven Miranda Suárez, Claudia Anabel Pesantez Zea, Mateo Daniel Fabara Vera, Bryan Steven Pasquel Rodríguez, Andrea Janet Zambrano Garces, Erick Santiago Velastegui Jijón, Angel Eduardo Romo Quintana, Katherine Lizeth Bautista Suárez

{"title":"Advances in stem cell therapy for articular cartilage lesions: clinical evidence and future directions: a systematic review","authors":"Kevin Steven Miranda Suárez, Claudia Anabel Pesantez Zea, Mateo Daniel Fabara Vera, Bryan Steven Pasquel Rodríguez, Andrea Janet Zambrano Garces, Erick Santiago Velastegui Jijón, Angel Eduardo Romo Quintana, Katherine Lizeth Bautista Suárez","doi":"10.18203/issn.2455-4510.intjresorthop20240935","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20240935","url":null,"abstract":"The significance of articular cartilage, an essential connective tissue, cannot be overstated in relation to joint health and functionality. Nevertheless, the human body might have adverse effects due to traumatic incidents, degenerative conditions, or repetitive stress, resulting in the manifestation of pain, inflammation, and impaired functionality. The primary objective of this study is to assess the effectiveness of stem cell therapy in the treatment of articular cartilage damage such as lesions. The systematic review was conducted adhering to the PRISMA principles. Boolean logic is employed in the search technique to integrate phrases pertaining to stem cell therapy, articular cartilage diseases, and biological processes. The research employs a range of databases and medical subject headings (MeSH) in order to facilitate a thorough examination. The stem cell therapy in the treatment of articular cartilage lesions has great potential. It enhances management and treatment outcomes for individuals afflicted with cartilage abnormalities. It is beneficial particularly those diagnosed with osteoarthritis (OA). Encouraging outcomes, such as alleviation of pain and improvement in functionality have been reported. Additional investigation is required to enhance therapy regimens, encompassing cell dosage, delivery techniques, and supplementary medicines. The use of stem cell therapies necessitates the imperative collaboration among researchers, doctors and regulatory agencies.","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":"37 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous release of trigger finger and its functional outcome 经皮松解扳机指及其功能效果

International Journal of Research in Orthopaedics Pub Date : 2024-02-19 DOI: 10.18203/issn.2455-4510.intjresorthop20240331

Sulabh Maheshwari, Aditya K. Mishra, Raunaq Saxena, Bilal Kaleem, N. Badoni

{"title":"Percutaneous release of trigger finger and its functional outcome","authors":"Sulabh Maheshwari, Aditya K. Mishra, Raunaq Saxena, Bilal Kaleem, N. Badoni","doi":"10.18203/issn.2455-4510.intjresorthop20240331","DOIUrl":"https://doi.org/10.18203/issn.2455-4510.intjresorthop20240331","url":null,"abstract":"Background: An overview of percutaneous release for trigger finger and its functional outcomes.\u0000Methods: The present prospective controlled analytical study was conducted after taking approval from center human ethical committee. A written and informed consent was obtained. There were 50 patients who reported to outpatient department (OPD) with symptoms suggestive of trigger thumb/ finger, were subjected to the study.\u0000Results: Most of the patients belonged to the age group of 41-50 years. Majority of patients were females (56%) and males were (44%). Most of the patients had the right 1st digit involved (32%), followed by left 1st and right 3rd digit (18% each). Before the release of affected digit, 56% were grade 3, 26% were grade 4 and only 18% were grade 1. Complete resolution immediately after the procedure was seen in 82% cases. Pre procedure, mean VAS of 8.4 reduced to mean VAS of 6.2 immediate post procedure. At 48 hours post procedure, mean VAS of 3.06 and mean VAS of 1.12 was seen at 1-month post procedure period. At 3 months post procedure, mean VAS of 0.42. 94% cases had no complications.\u0000Conclusions: Percutaneous release of trigger finger is a safe and effective procedure associated with favorable functional outcomes. It provides an alternative treatment option for patients who have failed conservative management or prefer a minimally invasive approach.","PeriodicalId":487580,"journal":{"name":"International Journal of Research in Orthopaedics","volume":"16 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140450867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0