Dermatological Health最新文献

{"title":"Collagen Synthesis During Wound Repair in Infected Albino Rats Using Ciprofloxacin-Loaded Gelatin Microspheres Incorporated into a Collagen Scaffold: A Histological Approach Using Masson’s Trichrome Staining","authors":"K. Shanmugam, Subha Veeramani, Deepa Priya R","doi":"10.26689/dh.v2i2.6222","DOIUrl":"https://doi.org/10.26689/dh.v2i2.6222","url":null,"abstract":"The production of collagen fibers is essential for wound healing because it creates a scaffold of collagen on which new cells may move and proliferate. It indicates cellular activity and improves strength and flexibility. Collagen synthesis is influenced by a number of factors, including age, health, infection, and diet. Collagen dressings often have the ability to increase the production of collagen. Collagen production can be adversely affected by infected cutaneous wounds, which can result in a delayed healing process, a higher risk of scarring, weakened tissue, and functional impairment. For this reason, in order to speed up wound healing, antimicrobial agents have been added to the collagen scaffold. Furthermore, the prolonged delivery of antimicrobial agent-loaded gelatin microspheres to infected wounds promotes quicker wound healing and effective collagen synthesis in the granulated tissue. These scaffolds may make superior wound dressings in clinical settings in light of this relationship.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of the Modified Myocutaneous Flap Method Combined with Orbital Septum Fixation in Blepharoplasty","authors":"Jie Wang, Longxu Zhou","doi":"10.26689/dh.v1i3.5946","DOIUrl":"https://doi.org/10.26689/dh.v1i3.5946","url":null,"abstract":"Objective: To explore the clinical efficacy of modified myocutaneous flap method combined with orbital septum fixation in treating patients with eye bags. Methods: The selected surgical plan divided 60 patients with eye bags into two groups. One group served as the control group and adopted the traditional myocutaneous flap method, while the other group was the observation group that implemented the modified myocutaneous flap method combined with orbital septum fixation. The general clinical observation indicators, treatment effect-related observation indicators, postoperative complication rates, and disease recurrence rates were compared between the two groups. Results: The total treatment time and postoperative recovery time of the observation group were significantly shorter than those of the control group. The degree of postoperative eye bag ptosis and lower eyelid skin wrinkle scores of the observation group were significantly lower than those of the control group. The nasolacrimal groove, skin glossiness, and White Aesthetics Score (WES) of the observation group were significantly higher than those of the control group. The total incidence of complications and disease recurrence rate in the observation group were significantly lower than those in the control group (P < 0.05). Conclusion: The modified myocutaneous flap method combined with orbital septum fixation for patients with eye bags can shorten the treatment and postoperative recovery time, improve the aesthetics of the eyes and face, and reduce the occurrence and recurrence rates of postoperative complications, thus it is worthy of promotion.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Effect of Bifidobacterium Triple Viable Bacteria Combined with Cetirizine in the Treatment of Eczema in Children and its Effect on Immunoglobulin Levels","authors":"Guang Hong","doi":"10.26689/dh.v1i3.5882","DOIUrl":"https://doi.org/10.26689/dh.v1i3.5882","url":null,"abstract":"Objective: To analyze the clinical effect of Bifidobacterium triple viable bacteria combined with cetirizine in the treatment of eczema in children and its impact on the immunoglobulin levels of the children. Methods: 50 children with eczema who received treatment in our hospital from January 2021 to December 2022 were selected as research subjects and divided into 25 cases in a group using the computer randomization method. In addition to basic treatment for both groups, patients in the control group were treated with cetirizine, while the observation group was treated with Bifidobacterium triple viable bacteria and cetirizine. The immunoglobulin levels, inflammatory factor levels, intestinal flora numbers, treatment effects, and recurrence rates within six months were compared between the two groups before and after treatment. Results: Before treatment, there was little difference in the indicators between the two groups of children (P> 0.05). After treatment, various immunoglobulins (IgM and IgG), inflammatory factors (interleukin-4 and interleukin-10), and the number of intestinal flora (including Escherichia coli, Lactobacillus, and Bifidobacterium) in the observation group was better than that of the control group, the total effective rate of treatment was higher than that of the control group, and the recurrence rate within six months was lower than that of the control group (P < 0.05). Conclusion: Bifidobacterium triple viable bacteria combined with cetirizine can actively regulate immunoglobulin levels and the number of intestinal flora, control inflammatory reactions, and have high treatment effectiveness and low recurrence rates in the treatment of pediatric eczema.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"21 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Open-Label Study of the Antifungal Activity of External Forms of Activated Zinc Pyrithione in the Treatment of Malassezia- Associated Skin Diseases","authors":"Alexey V. Samtsov, Alexandr V. Patrushev, Kseniya O. Chepushtanova, Tatiyana V. Bogdanova, Andrey Yu. Аlekseev, Tatiyana S. Bogomolova, Nataliya V. Vasilyeva","doi":"10.26689/dh.v1i2.5502","DOIUrl":"https://doi.org/10.26689/dh.v1i2.5502","url":null,"abstract":"Background: There are insufficient data on the antifungal activity of active zinc pyrithione, which is widely used in practice. Considering the reported role of Malassezia spp. in the pathogenesis of several dermatologic diseases, it is of scientific and practical importance to investigate this issue. Aim: To evaluate the antifungal activity of external forms of activated zinc pyrithione in the treatment of psoriasis, seborrheic dermatitis, and pityriasis versicolor. Method: An open-label prospective study was conducted between March and July 2022. Patients with psoriasis, seborrheic dermatitis, and pityriasis versicolor were treated with external forms of activated zinc pyrithione for 21 days. Skin scales and circular prints from lesion foci, as well as from skin areas without clinical manifestations before and after therapy were studied. A quantitative assessment of skin colonization by micromycetes of Malassezia was performed using microscopic and cultural methods of examination. Clinical efficacy and drug safety of the therapy was assessed using the Dermatological Symptom Scale Index, by recording adverse events at weeks 0, 1, 2, and 3. Results: 64 patients aged 18 to 65 years with diagnoses of psoriasis, seborrheic dermatitis, and pityriasis versicolor were included. 60 patients completed the study, 4 were excluded due to failure to adhere to the schedule. In patients with seborrheic dermatitis and pityriasis versicolor in the lesion foci after therapy, a significant decrease was observed in the colonization level according to the results of microscopic and cultural studies. In psoriasis patients, a significant decrease in the colonization level was obtained only based on the results of microscopic examination. In all groups, significant differences in comparison to the initial level were observed at the 1st week of treatment. There was no adverse events observed. Conclusion: Activated zinc pyrithione in the form of cream and aerosol showed moderate antifungal activity against micromycetes of the genus Malassezia.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Application of Mini Facelift in Facial Plastic Surgery","authors":"Huanla Yang","doi":"10.26689/dh.v1i2.5363","DOIUrl":"https://doi.org/10.26689/dh.v1i2.5363","url":null,"abstract":"Objective: This paper aims to study the clinical effect of mini facelift in patients undergoing facial plasticsurgery. Methods: The study period was from January 2021 to January 2023. One hundred cases were selected from patients with facial plastic surgery at our hospital. They were divided according to the two-color ball method into control group and study group. 50 cases in the control group underwent routine major facelift and skin flap surgery, while 50 patients in the study group underwent mini facelift surgery. The items to be compared between the two groups were clinical effects, psychological conditions, and satisfaction. Results: Based on the results, it was determined that the study group had shorter operation time and swelling period than the control group, and the difference between the groups was significant, P < 0.05. By comparing the Hamilton Anxiety Scale (HAM-A) score and the Hamilton Depression Scale (HAM-D) score, no preoperative symptoms were found in the two groups (P > 0.05). After surgery, the two scores in the study group decreased, and the difference between the study group and the control group can be expressed by P < 0.05. Moreover, itwas determined that the study group had higher satisfaction than the control group, and there is a significant difference between them, P < 0.05. Conclusion: The application of mini facelift in facial plastic surgery can shorten the operation time and swelling period, improve satisfaction, and relieve negative emotions, hence it is suitable for comprehensive clinical application.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety Analysis of 308nm Excimer Ultraviolet Light Combined with Carbon Dioxide Fractional Laser in the Treatment of Refractory Vitiligo","authors":"Gang Li","doi":"10.26689/dh.v1i2.5285","DOIUrl":"https://doi.org/10.26689/dh.v1i2.5285","url":null,"abstract":"This paper aims to explore the clinical effect and safety of combined application of 308 nm excimer ultravioletlight and carbon dioxide fractional laser in the treatment of refractory vitiligo. The study was carried out from January 2020 to December 2022. 60 patients with refractory vitiligo were selected and divided into the study group (n = 30) and the control group (n = 30) through the lottery method of medical record envelopes. The patients in the control group were treated with 308 nm excimer ultraviolet light, and the patients in the study group were treated with 308 nm excimer ultraviolet light combined with carbon dioxide fractional laser treatment. The clinical effective rate, leukoplakia area, IgG level, and incidence of adverse reactions were compared between the two groups. The clinical effective rate of the study group was higher than that of the control group (P < 0.05). After treatment, the leukoplakia area of the study group was lower than that of the control group (P < 0.05), and the IgG level of the study group was lower than that of the control group (P < 0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P < 0.05). The combined application of 308 nm excimer ultraviolet light and carbon dioxide fractional laser therapy for patients with refractory vitiligo has a significant effect, can reduce the area of leukoplakia and IgG levels, and has high treatment safety, which can be widely applied in clinical practice.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134958110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Therapeutic Efficacy of Mucopolysaccharide Polysulfate Cream Combined with Desonide Cream in the Treatment of Chronic Eczema","authors":"Yan Huang","doi":"10.26689/dh.v1i2.5410","DOIUrl":"https://doi.org/10.26689/dh.v1i2.5410","url":null,"abstract":"Objective: This paper aims to analyze the therapeutic efficacy of mucopolysaccharide polysulfate creamcombined with desonide cream in the treatment of chronic eczema. Methods: A sample of 70 patients with chronic eczema admitted from April 2022 to April 2023 were randomly divided into groups. Mucopolysaccharide polysulfate cream combined with desonide cream was applied in group A, and desonide cream was used in group B. The treatment efficacy was analyzed in both groups. Results: The curative effect on chronic eczema in group A was better than that in group B, P < 0.05. The target skin lesion area of group A was smaller than that of group B, and the skin lesion area score was lower than that of group B, P < 0.05. The skin lesion-symptom score of group A was lower than that of group B, P < 0.05. The treatment satisfaction of group A was higher than that of group B, P < 0.05. Conclusion: Patients with chronic eczema treated with mucopolysaccharide polysulfate cream combined with desonide cream can promote the regression of skin lesions and enhance the therapeutic efficacy.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134958111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Effect of Zygomatic Fat Pad Lifting Combined with Ultra-High SMAS Technique on the Improvement of Nasolabial Folds (Lower Eyelid Margin Incision)","authors":"Jun Xiao, Mandi Zhou, Chu Zhang, Yongjia Tan, Hongwei Shi","doi":"10.26689/dh.v1i2.5234","DOIUrl":"https://doi.org/10.26689/dh.v1i2.5234","url":null,"abstract":"This paper aims to explore the effect of zygomatic fat pad lifting combined with ultra-high superficial muscularaponeurotic system (SMAS) technique on the improvement of nasolabial folds. From December 2021 to June 2022, 40 patients with facial sagging were selected in our hospital to perform zygomatic fat pad lifting combined with ultra-high SMAS technology for large facelift surgery. Combined with lower eyelid incision and zygomatic fat pad degloving, the middle and lower face lift surgery, the improvement of the nasolabial fold, and the reduction of the apple cheeks were evaluated to assess the surgical effect. Statistics were collected on the improvement of nasolabial folds and apple cheeks aesthetic units before and after operation in 40 follow-up patients, and the satisfaction degree of nasolabial fold elevation and apple cheeks reduction was investigated and analyzed. The facial nasolabial folds and apple cheeks aesthetic units of 40 patients were followed-up after operation and compared with those before operation, and the difference was statistically significant (P < 0.05). After surgical treatment, 95% of patients were satisfied with the improvement of nasolabial folds, and 97.5% were satisfied with the reduction of apple cheeks. Zygomatic fat pad lifting combined with ultra-high SMAS technique has a significant effect on the reduction of apple cheeks zygomatic fat pad and nasolabial fold elevation, and it has clinical application value.","PeriodicalId":479747,"journal":{"name":"Dermatological Health","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134958348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}