Gout Urate and Crystal Deposition Disease最新文献

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Calcium Pyrophosphate and Basic Calcium Phosphate Deposition Diseases: The Year in Review 2022 焦磷酸钙和基础磷酸钙沉积病:年度回顾

Gout Urate and Crystal Deposition Disease Pub Date : 2023-10-12 DOI: 10.3390/gucdd1040019

Geraldine Mary McCarthy

{"title":"Calcium Pyrophosphate and Basic Calcium Phosphate Deposition Diseases: The Year in Review 2022","authors":"Geraldine Mary McCarthy","doi":"10.3390/gucdd1040019","DOIUrl":"https://doi.org/10.3390/gucdd1040019","url":null,"abstract":"Calcium-containing crystal deposition diseases are a common cause of pain and disability but remain relatively under-investigated. No drug has been identified that can prevent deposition or effect dissolution of either calcium pyrophosphate (CPP) or basic calcium phosphate (BCP) crystals. In comparison to the field of gout and urate biology, published research in relation to calcium crystal deposition diseases in 2022 was relatively modest in quantity. In CPP deposition (CPPD) disease, progress was made mainly in epidemiology, imaging, surgical management and Gitelman’s syndrome. In relation to BCP crystals, the effect on tenocytes in vitro was explored and results indicate that BCP crystals likely reduce tendon matrix integrity via their interaction with tenocytes. The involvement of calcification in the progression of osteoarthritis (OA) was elegantly demonstrated contributing to further discovery of the process of OA progression. There was a paucity of mechanistic and genetic studies in calcium crystal deposition diseases published in 2022, nor any breakthrough in therapy, showing that there is abundant scope for investigation under these themes in the future.","PeriodicalId":479415,"journal":{"name":"Gout Urate and Crystal Deposition Disease","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135968627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gout in Paleopathology: A Review with Some Etiological Considerations 痛风在古病理学:回顾与一些病因考虑

Gout Urate and Crystal Deposition Disease Pub Date : 2023-09-28 DOI: 10.3390/gucdd1040018

Nellissa Y. Ling, Siân E. Halcrow, Hallie R. Buckley

引用次数: 0

Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence 尿酸钠晶体血管沉积存在吗?证据审查

Gout Urate and Crystal Deposition Disease Pub Date : 2023-09-11 DOI: 10.3390/gucdd1030017

Tristan Pascart, Jean-François Budzik

{"title":"Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence","authors":"Tristan Pascart, Jean-François Budzik","doi":"10.3390/gucdd1030017","DOIUrl":"https://doi.org/10.3390/gucdd1030017","url":null,"abstract":"Cardiovascular disease in gout is a central issue, but the underlying mechanisms linking the two are unclear. The existence of monosodium (MSU) crystal deposition directly inflaming vessel walls has been recurrently suggested and challenged since the 1950s and is again a matter of active debate since recent studies using dual-energy computed tomography (DECT) suggested a higher prevalence of plaques considered to be containing MSU crystals in patients with gout. The objective of this review is to critically cover the evidence gathered on MSU crystal deposition in the cardiovascular system. In patients affected with gout, histological evidence of MSU crystals in arteries lacks a biochemical characterization supporting the observation in polarized light microscopy, while current knowledge on vascular lesions identified in DECT as containing MSU crystals suggests that they may be only artifacts, including in cadaveric and phantom studies. In individuals without gout, MSU crystal deposition in vessel walls have not been demonstrated, despite higher urate local plaque concentrations and increased xanthine oxidase activity. Gout is associated with increased arterial calcification and atherosclerosis, both being potential confounders of suspected MSU crystal deposition for the analysis of DECT scans and histopathology, respectively. In summary, the reality of the presence of MSU crystals in vascular plaques has not been demonstrated so far, and needs further investigation as it represents a potential outcome for cardiovascular complications of gout.","PeriodicalId":479415,"journal":{"name":"Gout Urate and Crystal Deposition Disease","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135980503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0