Jurnal Jamu Indonesia最新文献

{"title":"The Potential of Ethanol Extract of Temu Kunci (Boesenbergia rotunda (L.) Mansf.) Rhizomes as an Anticonvulsant Against Male White Rats","authors":"Agustin Yumita, Dwitiyanti, Risda Hidayati, Winza Putri","doi":"10.29244/jji.v9i1.308","DOIUrl":"https://doi.org/10.29244/jji.v9i1.308","url":null,"abstract":"The temu kunci extract was previously reported to have quite good antioxidant activity. One of the causes of seizures is oxidative stress. There has yet to be much exploration of temu kunci extract as an anticonvulsant. This study examines the anticonvulsant activity of 70% ethanol extract of Boesenbergia rotunda (L.) Mansf. against male white rats. The parameters observed were the onset and duration of HLE (Hind Limb Extension) with a digital electroconvulsiometer with a power of 150 mAmp and 50 hertz for 0.2 seconds. The test group was divided into five treatment groups, namely group 1 to group 3 (K1-K3), with extract doses: 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively, while K4 was a positive control using valproic acid (Depakote 1.54 mg/kgBW), and normal control group (K5) with Na-CMC 0.5%. The results were analyzed using one-way ANOVA and continued with the Tukey test. From the research carried out, information was obtained that 70% ethanol extract of temu kunci at a dose of 400 mg/kgBB had the best potential as an anticonvulsant in prolonging the onset of HLE (seconds) and shortening the duration of HLE (seconds) in mice comparable to the positive control. Temu kunci has the potential to be further developed as an anticonvulsant drug candidates in the future.","PeriodicalId":478179,"journal":{"name":"Jurnal Jamu Indonesia","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy and Histochemistry of Alliaceae and Iridaceae Species: Quality Control of Traditional Medicine Raw Materials","authors":"R. Syahruni, Abdul Halim Umar, Nur Afiah, Ramadhani Halim","doi":"10.29244/jji.v9i1.309","DOIUrl":"https://doi.org/10.29244/jji.v9i1.309","url":null,"abstract":"Alliaceae (Allium cepa and Allium ascalonicum) and Iridaceae (Eleutherine bulbosa) are widely used as spices, condiments, and traditional medicine. These three species are vulnerable to adulteration because they are morphologically similar in shape and colour. This study aims to identify and authenticate the three samples through anatomical and histochemical approaches. Anatomical and histochemical analyses were performed on fresh sections of the bulbs samples according to standard anatomical procedures with a razor blade and identification of the main compound groups using specific reagents. Anatomically, the three samples had similar patterns and cell organelles (cell nucleus, cytoplasm, and cell wall). Histochemical techniques identified the presence of alkaloids, phenolics, lipophilics, and terpenoids groups. Histochemical techniques can be applied in identifying the compound groups of the three samples and can be used as an alternative in testing the quality control of traditional medicine raw materials.","PeriodicalId":478179,"journal":{"name":"Jurnal Jamu Indonesia","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study","authors":"Hanifah Dwi Cahya, Nurlela Nurlela, D. Tohir, Irmanida Batubara, Shadila F Asoka, Kosei Yamauchi","doi":"10.29244/jji.v9i1.296","DOIUrl":"https://doi.org/10.29244/jji.v9i1.296","url":null,"abstract":"Breast cancer is a leading cause of cancer-related deaths in Indonesia. However, the drugs that are commonly used for treatment can cause side effects and become resistant over time. A study was conducted to test the cytotoxic activity of broadleaf mahogany (Swietenia macrophylla) seed extract on MCF-7 breast cancer cells in vitro. The study aimed to predict active compounds in the broadleaf mahogany seeds that have the potential to act as anti-breast cancer agents using in silico analysis. Molecular docking, visualization of the interaction between the receptor and the ligands, and physicochemical analysis were used to determine the most promising compounds. The receptors used were fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), insulin-like growth factor type 1 receptor (IGF-1R), estrogen receptor (ER-α), and progesterone receptor (PR). The results showed that 12 compounds have the potential to be active as anti-breast cancer agents. Three of these compounds, 3β,6-dihydroxydihydrocarapine, stigmasterol, and 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one, were predicted to have similar mechanisms of inhibition as a comparator drug based on binding site similarity values. These compounds are predicted to be taken orally and are promising for further research.","PeriodicalId":478179,"journal":{"name":"Jurnal Jamu Indonesia","volume":"116 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacy Study of Medicinal Plants Lampung Tribe in Pekon Tabuan Island, District Cukuh Balak, Tanggamus Regency, Lampung Province","authors":"Zulpakor Oktoba, Andi Nafisah Tendri Adjeng, Ari Irawan Romulya","doi":"10.29244/jji.v9i1.286","DOIUrl":"https://doi.org/10.29244/jji.v9i1.286","url":null,"abstract":"People in the Indonesian archipelago have long used medicinal plants as an alternative disease treatment. Tabuan Island is an area in Cukuh Balak District, Tanggamus Regency, Lampung Province, where most people are Lampung Peminggir /Pesisir tribe who still practice empirical medicine with local wisdom. Ethnopharmacy studies on Tabuan Island in the Lampung tribe have never been conducted and published. The study aimed to explore the knowledge of local communities regarding the types of medicinal plants for the search and development of new medicines. This research method includes area studies and descriptive studies in the form of ethnopharmacognosy-ethnopharmacology approaches in the Tabuan island community in 4 (four) villages or Pekon namely Pekon Sawang Balang, Pekon Suka Banjar, Pekon Kuta Kakhang, and Pekon Karang Buah used participatory observation methods and open interviews. The results showed that the Lampung Peminggir ethnic group on Tabuan Island still maintains ethnopharmaceutical traditions by utilizing plants used as medicine in 36 families of 76 species to treat diseases used singly or as a concoction accompanied by jampi. The most widely used plant families are Fabaceae, Zingiberaceae, Malvaceae, Meliaceae, and Poaceae. These medicinal plants in the Fabaceae family are most widely used to remedy mouth ulcers and skin problems such as tinea versicolor, ringworm, itching, acne, dandruff, diarrhea, and diabetes. Leaves are the most widely used plant parts, as much as 49.52%, and the least used plant parts are herbs, thallus, and fungi, while most of these plants are obtained in the garden. The most common way of processing medicinal plants is by stewing.","PeriodicalId":478179,"journal":{"name":"Jurnal Jamu Indonesia","volume":"201 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Phenolic Content in Black Rice (Oryza sativa L. indica) Bran Ethanolic Extract from Two Different Regions in Java, Indonesia","authors":"Afifah Vardhani, Nadia Bunga Anggraini, Mahdi Jufri, Erni Purwaningsih, Hidayah Sunar Perdanastuti","doi":"10.29244/jji.v9i1.293","DOIUrl":"https://doi.org/10.29244/jji.v9i1.293","url":null,"abstract":"Rice bran, a rice by-product yielded by the milling process, has recently been recognized as a potential source of natural active constituents. Black rice bran has the highest antioxidant capacity compared to white and brown rice bran. It is correlated with the contribution of phenolic compounds in rice bran. The purpose of this study was to determine the total phenolic content in black rice (Oryza sativa L. indica) bran ethanolic extract from two different regions in Java, Indonesia, using Folin-Ciocalteu Reagent (FCR). Black rice bran samples used in this study were planted in Ciletuh Geopark Sukabumi, West Java (BRBE1), and Karanganyar Regency, Central Java (BRBE2). The parameters observed were total phenolic content, and the result was statistically tested with an unpaired t-test by GraphPad Prism 8.3.0 application. The samples contained 175.48 mg GAE/g extract in BRBE1 and 174.39 mg GAE/g extract in BRBE2. There was no significant difference based on these results. It can be concluded that both samples contained phenolic compounds and statistically, there was no significant difference.","PeriodicalId":478179,"journal":{"name":"Jurnal Jamu Indonesia","volume":"18 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139960877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jamu as Indonesian Cultural Heritage and Modern Health Innovation","authors":"W. Nurcholis, Rini Arianti","doi":"10.29244/jji.v9i1.317","DOIUrl":"https://doi.org/10.29244/jji.v9i1.317","url":null,"abstract":"Jamu, as a traditional Indonesian medicine, stood firmly as a symbol of timeless cultural heritage wisdom amidst the hustle and bustle of modern civilization, with all its technological and medical advances. It has served as a reflection of philosophical underpinnings and a proven source of health in Indonesian society over thousands of years (Agustina & Fitrianti, 2020). In this editorial, we delve into how jamu, as Indonesia's cultural heritage, not only survived, but also thrived and adapted to modernization and globalization. We recognize that preserving herbal medicine requires concerted efforts, such as those undertaken by Satria et al. (2023), who utilized a casual game design to enhance the understanding and knowledge of herbal medicine. It is imperative to continue such endeavors to ensure the sustainability of herbal products in the future. \u0000The history of jamu was chronicled in ancient manuscripts and orally transmitted through generations by indigenous people of the archipelago. Each leaf, root, seed, and spice, when boiled or ground, contributed to a complex yet refined recipe, yielding a beverage imbued not only with health benefits, but also with the stories and prayers of ancestors. With every sip of jamu, it seemed as if we were directly assimilating the wisdom of our forebears who possessed a profound understanding of nature and the human body. However, the jamu did not remain confined to the past. In the modern era, it has undergone a transformation, permeating health clinics, spas, and even contemporary cafés. Scientific research has unveiled active components within jamu with therapeutic potential, corroborating beliefs held for centuries. For instance, studies on Curcuma xanthorrhiza have revealed the presence of xanthorrhizol compounds with anticancer properties (Nurcholis et al., 2018), while the utilization of curcuminoid compounds from turmeric in various functional food products exemplifies this trend (Munekata et al., 2021). This demonstrates that jamu, with its deep-rooted traditions, serves as a gateway for the future of integrative medicine. \u0000Currently, advances in jamu production are burgeoning. Ainurofiq et al. (2023) pioneered the granule formulation of SIRMA herbal medicine to heighten its antioxidant activity. Moreover, innovative marketing strategies are being implemented, such as leveraging websites and social media platforms (Purwantisari et al., 2022). Additionally, captivating packaging and creative marketing endeavors have effectively introduced jamu to both the younger generations and the international market. Collaborations with nutritionists and chefs have transformed jamu into not only a health elixir, but also a source of enjoyment.  However, along with its escalating popularity, challenges have surfaced. Standardization and certification have emerged as critical issues that uphold the quality and authenticity of herbal medicines. Several researchers have undertaken pivotal studies in this regard, in","PeriodicalId":478179,"journal":{"name":"Jurnal Jamu Indonesia","volume":"54 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139961330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}