PeerJ Organic Chemistry最新文献

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Synthesis of 1,2,3-triazole containing compounds as potential antimicrobial agents 合成含 1,2,3 三唑的化合物作为潜在的抗菌剂

PeerJ Organic Chemistry Pub Date : 2024-07-25 DOI: 10.7717/peerj-ochem.10

Elise L. Bezold, Robert J. Kempton, Keith D. Green, Ramey W. Hensley, Olivia K. Gilliam, S. Garneau‐Tsodikova, Amber J. Onorato

{"title":"Synthesis of 1,2,3-triazole containing compounds as potential antimicrobial agents","authors":"Elise L. Bezold, Robert J. Kempton, Keith D. Green, Ramey W. Hensley, Olivia K. Gilliam, S. Garneau‐Tsodikova, Amber J. Onorato","doi":"10.7717/peerj-ochem.10","DOIUrl":"https://doi.org/10.7717/peerj-ochem.10","url":null,"abstract":"Invasive fungal infections are increasing worldwide due to an expanding number of immunocompromised patients as well as an increase in drug-resistant fungi. While fungal resistance has increased, this resistance has not been accompanied by the development of new antifungals. A common class of antifungal agents that are prescribed are the azoles, which contain either a triazole or an imidazole group. Unfortunately, current azoles, like fluconazole, have been shown to be less effective with the increase in resistant fungal pathogens. Therefore, the development of novel azole antifungal compounds is of urgent need. The objective of this research was to synthesize triazole-containing small molecules with potent antifungal activity. The scaffold of the synthesized compounds contains a triazole moiety and was synthesized via a copper-catalyzed azide-alkyne click reaction (CuAAC) between the appropriate alkyne and azide intermediates. The minimum inhibitory concentrations of these compounds were determined using standard broth microdilution assays against opportunistic bacteria and fungi associated with life-threatening invasive fungal infections. Although the synthesized compounds possessed no antimicrobial activity, these results can be used to further the long-term goal of developing and optimizing lead compounds with potent in vitro antifungal activity.","PeriodicalId":477200,"journal":{"name":"PeerJ Organic Chemistry","volume":"33 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary plant flavonoid supplementation for poultry as a potent scavenger of hydroxyl radicals and antioxidants: a review 作为羟基自由基和抗氧化剂的有效清除剂为家禽补充膳食植物黄酮：综述

PeerJ Organic Chemistry Pub Date : 2024-03-26 DOI: 10.7717/peerj-ochem.9

Jiregna Gari Negasa

{"title":"Dietary plant flavonoid supplementation for poultry as a potent scavenger of hydroxyl radicals and antioxidants: a review","authors":"Jiregna Gari Negasa","doi":"10.7717/peerj-ochem.9","DOIUrl":"https://doi.org/10.7717/peerj-ochem.9","url":null,"abstract":"The poultry industry is paying more attention to plant-based feed additives. Flavonoids are plant secondary metabolites derived from fruits, grains, vegetables, herbs, and medicinal plants. One of the most significant environmental stressors affecting the poultry industry worldwide is heat stress, which lowers the quality and safety of production. An imbalance between the production of free radicals and the body’s natural antioxidant defenses leads to oxidative stress in cells. These reactive species can damage proteins, lipids, DNA, and cellular structures. Improving the antioxidant status of poultry bodies by feeding them antioxidant-supplemented feed can increase productivity and health. Plant flavonoid compounds have drawn attention from researchers as possible natural antioxidant sources because of their potential for use as feed additives in poultry production. Numerous studies have demonstrated that dietary flavonoids have strong antioxidant effects and can be utilized as a tonic in poultry to improve health and productivity. Overall, research on the antioxidant capacity of plant flavonoids has generally shown promising results; however, there are still significant issues regarding the detrimental effects of flavonoids to be resolved, and measuring oxidative damage in vivo is challenging. This review summarizes the current understanding of dietary plant flavonoid supplementation for poultry as a potent scavenger of hydroxyl radicals and antioxidants.","PeriodicalId":477200,"journal":{"name":"PeerJ Organic Chemistry","volume":"102 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0