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Immune response in autism, revealed by in-vivo studies of xenotransplanted human brain organoids 异种移植人脑类器官的体内研究揭示了自闭症的免疫反应
New Ground Pub Date : 2023-01-01 DOI: 10.56537/new-ground.2023.16118
Rohini Subrahmanyam
{"title":"Immune response in autism, revealed by in-vivo studies of xenotransplanted human brain organoids","authors":"Rohini Subrahmanyam","doi":"10.56537/new-ground.2023.16118","DOIUrl":"https://doi.org/10.56537/new-ground.2023.16118","url":null,"abstract":"Brain organoids facilitate the study of cell-cell interactions in a human-brain-like micro-environment but cannot form the primary immune cells of the central nervous system, microglia, on their own. Researchers have now transplanted forebrain organoids, colonized by stem-cell-derived microglial cells, into mice brains. And indeed, the stem-cell-derived microglial cells developed human-microglia-like transcriptomic and functional characteristics. This made it possible, for the first time, to study in-vivo immune responses in organoids derived from stem cell lines from patients with ASD and macrocephaly.","PeriodicalId":475844,"journal":{"name":"New Ground","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136208435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Point of Contention with Standard Cosmology 与标准宇宙学的争论点
New Ground Pub Date : 2023-01-01 DOI: 10.56537/new-ground.2023.49421
Fulvio Melia
{"title":"The Point of Contention with Standard Cosmology","authors":"Fulvio Melia","doi":"10.56537/new-ground.2023.49421","DOIUrl":"https://doi.org/10.56537/new-ground.2023.49421","url":null,"abstract":"With very few exceptions, cosmologists rely on the same starting points to construct a working model of the Universe. A rapidly growing body of high-precision cosmological data, however, has moved beyond the standard model’s ability to explain it. One possible culprit: the set of simplistic, built-in assumptions regarding the time-dependent form of the universal expansion factor, which are poorly motivated by fundamental theory.","PeriodicalId":475844,"journal":{"name":"New Ground","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136008258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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